Literature DB >> 27814838

Benzodiazepine Use in Older Adults: Dangers, Management, and Alternative Therapies.

Matej Markota1, Teresa A Rummans2, John Michael Bostwick1, Maria I Lapid1.   

Abstract

Several major medical and psychiatric organizations, including the American Geriatrics Society, advise against using benzodiazepines or nonbenzodiazepine hypnotics in older adults. Despite these recommendations, benzodiazepines continue to be massively prescribed to a group with the highest risk of serious adverse effects from these medications. This article summarizes legitimate reasons for prescribing benzodiazepines in the elderly, serious associated risks of prescribing them, particularly when not indicated, barriers physicians encounter in changing their prescription patterns, and evidence-based strategies on how to discontinue benzodiazepines in older patients. Although more research is needed, we propose several alternatives for treating insomnia and anxiety in older adults in primary care settings. These include nonpharmacological approaches such as sleep restriction-sleep compression therapy and cognitive behavioral therapy for anxiety or insomnia, and as well as alternative pharmacological agents.
Copyright © 2016 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

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Year:  2016        PMID: 27814838     DOI: 10.1016/j.mayocp.2016.07.024

Source DB:  PubMed          Journal:  Mayo Clin Proc        ISSN: 0025-6196            Impact factor:   7.616


  47 in total

Review 1.  Deprescribing Benzodiazepines in Older Patients: Impact of Interventions Targeting Physicians, Pharmacists, and Patients.

Authors:  Brendan J Ng; David G Le Couteur; Sarah N Hilmer
Journal:  Drugs Aging       Date:  2018-06       Impact factor: 3.923

Review 2.  Guidance for appropriate use of psychotropic drugs in older people.

Authors:  Andreas Capiau; Katrien Foubert; Annemie Somers; Mirko Petrovic
Journal:  Eur Geriatr Med       Date:  2021-01-08       Impact factor: 1.710

3.  Patient-Oriented Policies To Reduce The Harmful Effects Of Medication On Seniors' Brain Function.

Authors:  Lori A Daiello; Cara Tannenbaum
Journal:  Public Policy Aging Rep       Date:  2018-09-28

4.  Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia.

Authors:  Monika Marcinkowska; Adam Bucki; Joanna Sniecikowska; Agnieszka Zagórska; Nikola Fajkis-Zajączkowska; Agata Siwek; Monika Gluch-Lutwin; Paweł Żmudzki; Magdalena Jastrzebska-Wiesek; Anna Partyka; Anna Wesołowska; Michał Abram; Katarzyna Przejczowska-Pomierny; Agnieszka Cios; Elżbieta Wyska; Kamil Mika; Magdalena Kotańska; Paweł Mierzejewski; Marcin Kolaczkowski
Journal:  J Med Chem       Date:  2021-08-26       Impact factor: 7.446

Review 5.  Benzodiazepine Use and Cognition in the Elderly.

Authors:  Amber R Toombs; Joon Y Jung; Nicole D White
Journal:  Am J Lifestyle Med       Date:  2018-04-13

6.  Risk of Fractures in Older Adults with Chronic Non-cancer Pain Receiving Concurrent Benzodiazepines and Opioids: A Nested Case-Control Study.

Authors:  Ye-Jin Kang; Min-Taek Lee; Myo-Song Kim; Seung-Hun You; Jae-Eun Lee; Joo-Hyeon Eom; Sun-Young Jung
Journal:  Drugs Aging       Date:  2021-06-23       Impact factor: 3.923

7.  Potentially inappropriate medication in older psychiatric patients.

Authors:  Gudrun Hefner; Martina Hahn; Sermin Toto; Christoph Hiemke; Sibylle C Roll; Jan Wolff; Ansgar Klimke
Journal:  Eur J Clin Pharmacol       Date:  2020-10-08       Impact factor: 2.953

8.  Real-world Effectiveness of Pharmacologic Treatments for the Prevention of Rehospitalization in a Finnish Nationwide Cohort of Patients With Bipolar Disorder.

Authors:  Markku Lähteenvuo; Antti Tanskanen; Heidi Taipale; Fabian Hoti; Pia Vattulainen; Eduard Vieta; Jari Tiihonen
Journal:  JAMA Psychiatry       Date:  2018-04-01       Impact factor: 21.596

9.  Pharmacological Management of Neuropsychiatric Symptoms of Dementia.

Authors:  Lauren B Gerlach; Helen C Kales
Journal:  Curr Treat Options Psychiatry       Date:  2020-09-02

10.  Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation.

Authors:  Thomas D Prevot; Akiko Sumitomo; Toshifumi Tomoda; Daniel E Knutson; Guanguan Li; Prithu Mondal; Mounira Banasr; James M Cook; Etienne Sibille
Journal:  Cereb Cortex       Date:  2021-01-05       Impact factor: 5.357

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