Yuji Toiyama1, Hiromi Yasuda2, Masaki Ohi2, Shigeyuki Yoshiyama2, Toshimitsu Araki2, Koji Tanaka2, Yasuhiro Inoue2, Yasuhiko Mohri2, Masato Kusunoki2. 1. Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan. Electronic address: ytoi0725@clin.medic.mie-u.ac.jp. 2. Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan.
Abstract
BACKGROUND: Low albumin-to-globulin ratio (AGR) is associated with increased cancer mortality in patients with various cancers. However, there are no reports regarding the relation between pretreatment AGR and clinicopathological data, including oncological outcomes, in gastric cancer (GC) patients with curative intent. METHODS: Clinicopathological findings including preoperative laboratory data from 384 curative GC patients were assessed as indicators of early recurrence and poor prognosis in this retrospective study. AGR was calculated as albumin/(total protein - albumin)]. RESULTS: Several pathological categories related to tumor progression were associated with low AGR levels. Among preoperative serum markers, AGR was an independent predictor of early recurrence in curative GC patients. By multivariate analysis using both preoperative serum markers and postoperative clinicopathological categories, 2 pathological factors, lymph node metastasis and serosal invasion, and low AGR were independently associated with early recurrence. Furthermore, GC patients with low AGR showed significantly poor disease-free survival in the lymph node metastasis and serosal invasion groups. CONCLUSIONS: AGR was a novel independent predictor of early recurrence in curative GC patients.
BACKGROUND: Low albumin-to-globulin ratio (AGR) is associated with increased cancer mortality in patients with various cancers. However, there are no reports regarding the relation between pretreatment AGR and clinicopathological data, including oncological outcomes, in gastric cancer (GC) patients with curative intent. METHODS: Clinicopathological findings including preoperative laboratory data from 384 curative GC patients were assessed as indicators of early recurrence and poor prognosis in this retrospective study. AGR was calculated as albumin/(total protein - albumin)]. RESULTS: Several pathological categories related to tumor progression were associated with low AGR levels. Among preoperative serum markers, AGR was an independent predictor of early recurrence in curative GC patients. By multivariate analysis using both preoperative serum markers and postoperative clinicopathological categories, 2 pathological factors, lymph node metastasis and serosal invasion, and low AGR were independently associated with early recurrence. Furthermore, GC patients with low AGR showed significantly poor disease-free survival in the lymph node metastasis and serosal invasion groups. CONCLUSIONS: AGR was a novel independent predictor of early recurrence in curative GC patients.
Authors: Oktay Halit Aktepe; Gürkan Güner; Deniz Can Güven; Hakan Taban; Hasan Çağrı Yıldırım; Taha Koray Şahin; Fadime Sinem Ardıç; Hacı Hasan Yeter; Deniz Yüce; Mustafa Erman Journal: Turk J Urol Date: 2021-03-01