Literature DB >> 278146

Experimental models for studies on transportation of antibiotics to extravasal compartments.

S E Holm.   

Abstract

A short review is presented illustrating different methods employed to determine the antibiotic concentration in different tissues in man and the limitation to perform thorough pharmacokinetic studies. The most often used experimental models (different tissue cage models the fibrin clot, skin blisters, skin windows, skin chambers) applied in animal and man for studies of antibiotics are presented as well as a discussion concerning their relevance to the clinical situation.

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Year:  1978        PMID： 278146

Source DB:  PubMed          Journal:  Scand J Infect Dis Suppl        ISSN： 0300-8878


  8 in total

Review 1.  Microdialysis: current applications in clinical pharmacokinetic studies and its potential role in the future.

Authors:  Christian Joukhadar; Markus Müller
Journal:  Clin Pharmacokinet       Date:  2005       Impact factor: 6.447

2.  Pharmacokinetics of cefpodoxime in plasma and skin blister fluid following oral dosing of cefpodoxime proxetil.

Authors:  M T Borin; G S Hughes; C R Spillers; R K Patel
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

3.  Simultaneous comparison of three methods for assessing ceftazidime penetration into extravascular fluid.

Authors:  D M Ryan; B Hodges; G R Spencer; S M Harding
Journal:  Antimicrob Agents Chemother       Date:  1982-12       Impact factor: 5.191

4.  A diffusion chamber technique for measuring concentrations of antibiotics in interstitial fluid.

Authors:  G Laber; E Schütze; R Leskova; R Kolb; A Georgopoulos
Journal:  Infection       Date:  1980       Impact factor: 3.553

5.  Therapeutic relevance of penicillin-induced hypersensitivity of Staphylococcus aureus to killing by polymorphonuclear leukocytes.

Authors:  C Lam; A Georgopoulos; G Laber; E Schütze
Journal:  Antimicrob Agents Chemother       Date:  1984-08       Impact factor: 5.191

6.  Gentamicin concentrations in human subcutaneous tissue.

Authors:  H Lorentzen; F Kallehave; H J Kolmos; U Knigge; J Bülow; F Gottrup
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191

7.  Methicillin distribution in serum and extravascular fluid and its relevance to normal and damaged heart valves.

Authors:  F M Gengo; J J Schentag
Journal:  Antimicrob Agents Chemother       Date:  1981-05       Impact factor: 5.191

8.  Performance of a diffusional clearance model for beta-lactam antimicrobial agents as influenced by extravascular protein binding and interstitial fluid kinetics.

Authors:  J C Fleishaker; P J McNamara
Journal:  Antimicrob Agents Chemother       Date:  1985-09       Impact factor: 5.191
  8 in total

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