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Literature DB >> 7390622

A diffusion chamber technique for measuring concentrations of antibiotics in interstitial fluid.

G Laber, E Schütze, R Leskova, R Kolb, A Georgopoulos.

Abstract

A method for collecting soft tissue interstitial fluid in experimental animals for the measurement of antibiotic concentrations is described. Diffusion chambers with permeable membranes of 0.45 micron porosity were implanted subcutaneously for four days in order to determine simultaneous concentrations of ampicillin and clindamycin in serum and chamber fluid after perioral administration in rabbits and of oxytetracycline after intravenous injection in dogs. The results are discussed in view of findings from other investigators using different types of tissue cages.

Entities: Chemical Species

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Year: 1980 PMID： 7390622 DOI： 10.1007/bf01639147

Source DB: PubMed Journal: Infection ISSN： 0300-8126 Impact factor: 3.553

21 in total

1. Effect of mouse peritoneal fluid on strains of enteric bacilli.

Authors: J P STEWARD; R J ROANTREE
Journal: Proc Soc Exp Biol Med Date: 1961-12

2. Growth of cells in vivo in diffusion chambers. I. Survival of homografts in immunized mice.

Authors: G H ALGIRE; J M WEAVER; R T PREHN
Journal: J Natl Cancer Inst Date: 1954-12 Impact factor: 13.506

3. Antibiotic concentrations in hepatic interstitial and wound fluid.

Authors: N G Waterman; M J Raff; L Scharfenberger; P A Barnwell
Journal: Surg Gynecol Obstet Date: 1976-02

4. Enhanced interstitial ampicillin levels after oral bacampicillin.

Authors: C Carbon; A Contrepois; C Beauvais; S Lamotte-Barrilon
Journal: J Antimicrob Chemother Date: 1976-09 Impact factor: 5.790

5. Implanted tissue-cages: a critical evaluation of their relevance in measuring tissue concentrations of antibiotics.

Authors: D M Ryan
Journal: Scand J Infect Dis Suppl Date: 1978

6. Collection and physiological measurements of peripheral lymph and interstitial fluid in man.

Authors: W L Olszewski
Journal: Lymphology Date: 1977-06 Impact factor: 1.286

7. Concentration of antibacterial agents in interstitial tissue fluid.

Authors: G D Chisholm; P M Waterworth; J S Calnan; L P Garrod
Journal: Br Med J Date: 1973-03-10

8. Pathophysiology of tissue fluid.

Authors: J S Calnan; J J Pflug; G D Chisholm; L M Taylor
Journal: Proc R Soc Med Date: 1972-08

9. Interstitial fluid and serum antibiotic concentrations.

Authors: N G Waterman; L B Kastan
Journal: Arch Surg Date: 1972-08

10. Cephalosporin and aminoglycoside concentrations in peritoneal capsular fluid in rabbits.

Authors: D N Gerding; W H Hall; E A Schierl; R E Manion
Journal: Antimicrob Agents Chemother Date: 1976-12 Impact factor: 5.191

8 in total

1. Evaluation of cytostatic drug concentrations in the kidney, bladder wall, and prostate by means of the diffusion chamber technique in dogs.

Authors: P Porpaczy; C P Schmidbauer; A Georgopoulos; H Rameis; T A Endler
Journal: Urol Res Date: 1983

2. Pharmacokinetics of high-dose methotrexate in dogs. An experimental model with diffusion chambers.

Authors: P Porpaczy; C P Schmidbauer; A Georgopoulos; A T Endler
Journal: Cancer Chemother Pharmacol Date: 1983 Impact factor: 3.333

3. Distribution of ceftazidime in ascitic fluid.

Authors: G Benoni; E Arosio; M G Raimondi; E Apolloni; E Passarella; A Lechi; G P Velo
Journal: Antimicrob Agents Chemother Date: 1984-06 Impact factor: 5.191

4. Influence of serum protein binding and mode of administration on penetration of five cephalosporins into subcutaneous tissue fluid in humans.

Authors: B Hoffstedt; M Walder
Journal: Antimicrob Agents Chemother Date: 1981-12 Impact factor: 5.191