| Literature DB >> 27814566 |
Yi-Chao Zheng1, Dan-Dan Shen1, Meng Ren1, Xue-Qi Liu1, Zhi-Ru Wang1, Ying Liu1, Qian-Na Zhang1, Li-Juan Zhao1, Li-Jie Zhao1, Jin-Lian Ma1, Bin Yu1, Hong-Min Liu2.
Abstract
Baicalin is one of the active ingredients in the skullcap, with a variety of pharmacological effects, such as blood pressure reduction, sedation, liver-protection, gallbladder-protection, anti-bacteria, and anti-inflammation. In our study, baicalin was first characterized as a LSD1 inhibitor with an IC50 of 3.01μM and showed strong LSD1 inhibitory effect in cells. Baicalin may serve as a template for designing flavone-based LSD1 inhibitors.Entities:
Keywords: Baicalin; Inhibitor; LSD1
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Year: 2016 PMID： 27814566 DOI： 10.1016/j.bioorg.2016.10.004
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275