Literature DB >> 2781282

Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor.

E E Baulieu1.   

Abstract

RU 486, a steroid with high affinity for the progesterone receptor, is the first available active antiprogesterone. It has been used successfully as a medical alternative for early pregnancy interruption, and it also has other potential applications in medicine and for biochemical and pathophysiological endocrine research.

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Year:  1989        PMID： 2781282     DOI： 10.1126/science.2781282

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  68 in total

Review 1.  Proven and potential clinical applications of mifpristone (RU486).

Authors:  Irving M Spitz
Journal:  Rev Endocr Metab Disord       Date:  2002-09       Impact factor: 6.514

2.  RU 486.

Authors:  A Rosenfield
Journal:  Am J Public Health       Date:  1992-10       Impact factor: 9.308

3.  Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers.

Authors:  T A Pham; J F Elliston; Z Nawaz; D P McDonnell; M J Tsai; B W O'Malley
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

4.  Turtle oviduct progesterone receptor: radioligand and immunocytochemical studies of changes during the seasonal cycle.

Authors:  G Giannoukos; D W Coho; I P Callard
Journal:  Endocrine       Date:  1995-06       Impact factor: 3.633

5.  Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells.

Authors:  L Klein-Hitpass; A C Cato; D Henderson; G U Ryffel
Journal:  Nucleic Acids Res       Date:  1991-03-25       Impact factor: 16.971

6.  Progesterone and RU486: opposing effects on human sperm.

Authors:  J Yang; C Serres; D Philibert; P Robel; E E Baulieu; P Jouannet
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

7.  The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.

Authors:  D X Wen; Y F Xu; D E Mais; M E Goldman; D P McDonnell
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

8.  Effect of medroxyprogesterone acetate (MPA) and serum factors on cell proliferation in primary cultures of an MPA-induced mammary adenocarcinoma.

Authors:  G Dran; I A Luthy; A A Molinolo; F Montecchia; E H Charreau; C D Pasqualini; C Lanari
Journal:  Breast Cancer Res Treat       Date:  1995-08       Impact factor: 4.872

9.  Effects of progesterone (P) and antiprogestin RU486 on LH and FSH release by incubated pituitaries from rats treated with the SERM LY11701 8-HCl and/or recombinant human FSH.

Authors:  C Bellido; R Aguilar; J C Garrido-Gracia; J E Sánchez-Criado
Journal:  J Endocrinol Invest       Date:  2002-09       Impact factor: 4.256

10.  Progesterone receptor B recruits a repressor complex to a half-PRE site of the estrogen receptor alpha gene promoter.

Authors:  F De Amicis; S Zupo; M L Panno; R Malivindi; F Giordano; I Barone; L Mauro; S A W Fuqua; S Andò
Journal:  Mol Endocrinol       Date:  2009-01-15
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