Robert Zivadinov1, Deepa P Ramasamy2, Manuela Vaneckova3, Sirin Gandhi2, Avinash Chandra2, Jesper Hagemeier2, Niels Bergsland4, Paul Polak2, Ralph Hb Benedict5, David Hojnacki5, Bianca Weinstock-Guttman5. 1. Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo-The State University of New York, Buffalo, NY, USA/MR Imaging Clinical Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo-The State University of New York, Buffalo, NY, USA. 2. Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo-The State University of New York, Buffalo, NY, USA. 3. Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. 4. Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo-The State University of New York, Buffalo, NY, USA/IRCCS "S. Maria Nascente," Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy. 5. Jacobs Multiple Sclerosis Center, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo-The State University of New York, Buffalo, NY, USA.
Abstract
BACKGROUND: Leptomeningeal contrast enhancement (LM CE) has been recently described in multiple sclerosis (MS) patients as a potential in vivo marker of cortical pathology. OBJECTIVES: To investigate the association of LM CE and development of cortical atrophy in 50 MS patients (27 relapsing-remitting (RR) and 23 secondary-progressive (SP)) followed for 5 years. METHODS: The presence and number of LM CE foci were assessed only at the 5-year follow-up using three-dimensional (3D) fluid-attenuated inversion recovery magnetic resonance imaging (MRI) sequence obtained 10 minutes after single dose of gadolinium injection on 3T scanner. The percentage change in whole brain, cortical and deep gray matter (GM) volumes, and lesion volume (LV) was measured between baseline and the 5-year follow-up. RESULTS: In total, 25 (50%) of MS patients had LM CE at the 5-year follow-up. Significantly more SPMS patients (12, 85.7%) had multiple LM CE foci, compared to those with RRMS (2, 18.2%) ( p = 0.001). MS patients with LM CE showed significantly greater percentage decrease in total GM (-3.6% vs -2%, d = 0.80, p = 0.006) and cortical (-3.4% vs -1.8%, d = 0.84, p = 0.007) volumes and greater percentage increase in ventricular cerebrospinal fluid (vCSF) volume (22.8% vs 9.9%, d = 0.90, p = 0.003) over the follow-up, compared to those without. CONCLUSION: In this retrospective, pilot, observational longitudinal study, the presence of LM CE was associated with progression of cortical atrophy over 5 years.
BACKGROUND: Leptomeningeal contrast enhancement (LM CE) has been recently described in multiple sclerosis (MS) patients as a potential in vivo marker of cortical pathology. OBJECTIVES: To investigate the association of LM CE and development of cortical atrophy in 50 MSpatients (27 relapsing-remitting (RR) and 23 secondary-progressive (SP)) followed for 5 years. METHODS: The presence and number of LM CE foci were assessed only at the 5-year follow-up using three-dimensional (3D) fluid-attenuated inversion recovery magnetic resonance imaging (MRI) sequence obtained 10 minutes after single dose of gadolinium injection on 3T scanner. The percentage change in whole brain, cortical and deep gray matter (GM) volumes, and lesion volume (LV) was measured between baseline and the 5-year follow-up. RESULTS: In total, 25 (50%) of MSpatients had LM CE at the 5-year follow-up. Significantly more SPMS patients (12, 85.7%) had multiple LM CE foci, compared to those with RRMS (2, 18.2%) ( p = 0.001). MSpatients with LM CE showed significantly greater percentage decrease in total GM (-3.6% vs -2%, d = 0.80, p = 0.006) and cortical (-3.4% vs -1.8%, d = 0.84, p = 0.007) volumes and greater percentage increase in ventricular cerebrospinal fluid (vCSF) volume (22.8% vs 9.9%, d = 0.90, p = 0.003) over the follow-up, compared to those without. CONCLUSION: In this retrospective, pilot, observational longitudinal study, the presence of LM CE was associated with progression of cortical atrophy over 5 years.
Authors: Mehrnaz Ighani; Samuel Jonas; Izlem Izbudak; Seongjin Choi; Alfonso Lema-Dopico; Jun Hua; Erin E O'Connor; Daniel M Harrison Journal: Mult Scler Date: 2019-10-01 Impact factor: 6.312
Authors: Martina Absinta; Irene C M Cortese; Luisa Vuolo; Govind Nair; Manori P de Alwis; Joan Ohayon; Alessandro Meani; Vittorio Martinelli; Roberta Scotti; Andrea Falini; Bryan R Smith; Avindra Nath; Steven Jacobson; Massimo Filippi; Daniel S Reich Journal: Neurology Date: 2017-03-10 Impact factor: 9.910
Authors: W M Freeze; D N Ter Weele; W M Palm; R W van Hooren; E I Hoff; J F A Jansen; H I L Jacobs; F R Verhey; W H Backes Journal: AJNR Am J Neuroradiol Date: 2019-08-08 Impact factor: 3.825
Authors: Daniel M Harrison; Kevin Y Wang; Julie Fiol; Kerry Naunton; Walter Royal; Jun Hua; Izlem Izbudak Journal: J Neuroimaging Date: 2017-05-02 Impact factor: 2.486
Authors: L Pelizzari; D Jakimovski; M M Laganà; N Bergsland; J Hagemeier; G Baselli; B Weinstock-Guttman; R Zivadinov Journal: AJNR Am J Neuroradiol Date: 2018-07-26 Impact factor: 3.825