Literature DB >> 27810991

Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia.

Sachith Mettananda1,2, Christopher A Fisher1, Jackie A Sloane-Stanley3, Stephen Taylor3, Udo Oppermann4,5, Richard J Gibbons1, Douglas R Higgs6,7.   

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Year:  2016        PMID： 27810991      PMCID： PMC5394973          DOI： 10.3324/haematol.2016.155655

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


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  14 in total

Review 1.  Histone lysine demethylases: emerging roles in development, physiology and disease.

Authors:  Yang Shi
Journal:  Nat Rev Genet       Date:  2007-11       Impact factor: 53.242

2.  The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.

Authors:  David Garrick; Marco De Gobbi; Vasiliki Samara; Michelle Rugless; Michelle Holland; Helena Ayyub; Karen Lower; Jackie Sloane-Stanley; Nicki Gray; Christoph Koch; Ian Dunham; Douglas R Higgs
Journal:  Blood       Date:  2008-08-08       Impact factor: 22.113

Review 3.  Understanding alpha-globin gene regulation: Aiming to improve the management of thalassemia.

Authors:  D R Higgs; D Garrick; E Anguita; M De Gobbi; J Hughes; M Muers; D Vernimmen; K Lower; M Law; A Argentaro; M A Deville; R Gibbons
Journal:  Ann N Y Acad Sci       Date:  2005       Impact factor: 5.691

4.  Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.

Authors:  James E Bradner; Raymond Mak; Shyam K Tanguturi; Ralph Mazitschek; Stephen J Haggarty; Kenneth Ross; Cindy Y Chang; Jocelyn Bosco; Nathan West; Elizabeth Morse; Katherine Lin; John Paul Shen; Nicholas P Kwiatkowski; Nele Gheldof; Job Dekker; Daniel J DeAngelo; Steven A Carr; Stuart L Schreiber; Todd R Golub; Benjamin L Ebert
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-28       Impact factor: 11.205

Review 5.  Understanding α-globin gene regulation and implications for the treatment of β-thalassemia.

Authors:  Sachith Mettananda; Richard J Gibbons; Douglas R Higgs
Journal:  Ann N Y Acad Sci       Date:  2015-12-22       Impact factor: 5.691

Review 6.  Thalassaemia.

Authors:  Douglas R Higgs; James Douglas Engel; George Stamatoyannopoulos
Journal:  Lancet       Date:  2011-09-09       Impact factor: 79.321

7.  Expression of alpha- and beta-globin genes occurs within different nuclear domains in haemopoietic cells.

Authors:  K E Brown; S Amoils; J M Horn; V J Buckle; D R Higgs; M Merkenschlager; A G Fisher
Journal:  Nat Cell Biol       Date:  2001-06       Impact factor: 28.824

8.  Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

Authors:  Renzo Galanello; Serena Sanna; Lucia Perseu; Maria Carla Sollaino; Stefania Satta; Maria Eliana Lai; Susanna Barella; Manuela Uda; Gianluca Usala; Goncalo R Abecasis; Antonio Cao
Journal:  Blood       Date:  2009-08-20       Impact factor: 22.113

9.  5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

Authors:  Richard J Hopkinson; Anthony Tumber; Clarence Yapp; Rasheduzzaman Chowdhury; WeiShen Aik; Ka Hing Che; Xuan Shirley Li; Jan B L Kristensen; Oliver N F King; Mun Chiang Chan; Kar Kheng Yeoh; Hwanho Choi; Louise J Walport; Cyrille C Thinnes; Jacob T Bush; Clarisse Lejeune; Anna M Rydzik; Nathan R Rose; Eleanor A Bagg; Michael A McDonough; Tobias Krojer; Wyatt W Yue; Stanley S Ng; Lars Olsen; Paul E Brennan; Udo Oppermann; Susanne Muller-Knapp; Robert J Klose; Peter J Ratcliffe; Christopher J Schofield; Akane Kawamura
Journal:  Chem Sci       Date:  2013-08-01       Impact factor: 9.825

10.  Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

Authors:  Oliver N F King; Xuan Shirley Li; Masaaki Sakurai; Akane Kawamura; Nathan R Rose; Stanley S Ng; Amy M Quinn; Ganesha Rai; Bryan T Mott; Paul Beswick; Robert J Klose; Udo Oppermann; Ajit Jadhav; Tom D Heightman; David J Maloney; Christopher J Schofield; Anton Simeonov
Journal:  PLoS One       Date:  2010-11-23       Impact factor: 3.240
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  16 in total

Review 1.  New therapeutic targets in transfusion-dependent and -independent thalassemia.

Authors:  M Domenica Cappellini; Irene Motta
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2017-12-08

Review 2.  Molecular basis of β thalassemia and potential therapeutic targets.

Authors:  Swee Lay Thein
Journal:  Blood Cells Mol Dis       Date:  2017-06-20       Impact factor: 3.039

3.  Correction of β-thalassemia by CRISPR/Cas9 editing of the α-globin locus in human hematopoietic stem cells.

Authors:  Giulia Pavani; Anna Fabiano; Marine Laurent; Fatima Amor; Erika Cantelli; Anne Chalumeau; Giulia Maule; Alexandra Tachtsidi; Jean-Paul Concordet; Anna Cereseto; Fulvio Mavilio; Giuliana Ferrari; Annarita Miccio; Mario Amendola
Journal:  Blood Adv       Date:  2021-03-09

Review 4.  Oxidative Stress in β-Thalassemia.

Authors:  Eitan Fibach; Mutaz Dana
Journal:  Mol Diagn Ther       Date:  2019-04       Impact factor: 4.074

Review 5.  A comprehensive review of hydroxyurea for β-haemoglobinopathies: the role revisited during COVID-19 pandemic.

Authors:  Nirmani Yasara; Anuja Premawardhena; Sachith Mettananda
Journal:  Orphanet J Rare Dis       Date:  2021-03-01       Impact factor: 4.123

6.  Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.

Authors:  Sachith Mettananda; Chris A Fisher; Deborah Hay; Mohsin Badat; Lynn Quek; Kevin Clark; Philip Hublitz; Damien Downes; Jon Kerry; Matthew Gosden; Jelena Telenius; Jackie A Sloane-Stanley; Paula Faustino; Andreia Coelho; Jessica Doondeea; Batchimeg Usukhbayar; Paul Sopp; Jacqueline A Sharpe; Jim R Hughes; Paresh Vyas; Richard J Gibbons; Douglas R Higgs
Journal:  Nat Commun       Date:  2017-09-04       Impact factor: 14.919

Review 7.  Epigenetic Insights and Potential Modifiers as Therapeutic Targets in β-Thalassemia.

Authors:  Nur Atikah Zakaria; Md Asiful Islam; Wan Zaidah Abdullah; Rosnah Bahar; Abdul Aziz Mohamed Yusoff; Ridhwan Abdul Wahab; Shaharum Shamsuddin; Muhammad Farid Johan
Journal:  Biomolecules       Date:  2021-05-18

8.  IOX1 Suppresses Wnt Target Gene Transcription and Colorectal Cancer Tumorigenesis through Inhibition of KDM3 Histone Demethylases.

Authors:  Rosalie G Hoyle; Huiqun Wang; Yana Cen; Yan Zhang; Jiong Li
Journal:  Mol Cancer Ther       Date:  2020-11-17       Impact factor: 6.009

Review 9.  Pathophysiology and treatment of patients with beta-thalassemia - an update.

Authors:  Eitan Fibach; Eliezer A Rachmilewitz
Journal:  F1000Res       Date:  2017-12-20

10.  Body iron status of children and adolescents with transfusion dependent β-thalassaemia: trends of serum ferritin and associations of optimal body iron control.

Authors:  Tharindi Suriapperuma; Ravindu Peiris; Chamila Mettananda; Anuja Premawardhena; Sachith Mettananda
Journal:  BMC Res Notes       Date:  2018-08-02
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