| Literature DB >> 27810966 |
Santhosh A Upadhyaya1, Carl Koschmann2, Karin Muraszko3, Sriram Venneti4, Hugh J Garton3, Daniel A Hamstra5, Cormac O Maher3, Bryan L Betz4, Noah A Brown4, Daniel Wahl6, Helmut C Weigelin4, Kathleen E DuRoss4, Annette S Leonard4, Patricia L Robertson2,7.
Abstract
Safe maximal surgical resection is the initial treatment of choice for pediatric brainstem low-grade gliomas. Optimal therapy for incompletely resected tumors or that progress after surgery is uncertain. We reviewed the clinical characteristics, therapy, and outcomes of all children with nontectal brainstem low-grade gliomas treated at the University of Michigan between 1993 and 2013. Median age at diagnosis was 6 years; histology was confirmed in 23 of 25 tumors, 64% were pilocytic astrocytoma. Nineteen patients underwent initial tumor resection; 14/19 received no upfront adjuvant therapy. Eight patients in the study had progressive disease; 5 initially resected tumors received chemotherapy at tumor relapse, all with partial or complete radiographic responses. Ten-year progression-free survival is 71% and overall survival, 100%. This single-institution retrospective study demonstrates excellent survival rates for children with brainstem low-grade gliomas. The efficacy of the well-tolerated chemotherapy in this series supports its role in the treatment of unresectable or progressive brainstem low-grade gliomas.Entities:
Keywords: brainstem tumors; chemotherapy; low-grade glioma; overall survival; progressive tumors
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Year: 2016 PMID： 27810966 PMCID： PMC5582383 DOI： 10.1177/0883073816675547
Source DB: PubMed Journal: J Child Neurol ISSN： 0883-0738 Impact factor: 1.987