Literature DB >> 27805726

A Micropatterned Human Pluripotent Stem Cell-Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug-Induced Arrhythmogenicity.

Angie M Y Shum1, Hui Che1, Andy On-Tik Wong1, Chenzi Zhang1, Hongkai Wu2, Camie W Y Chan3, Kevin Costa4, Michelle Khine5, Chi-Wing Kong1, Ronald A Li6,7.   

Abstract

A novel cardiomimetic biohybrid material, termed as the human ventricular cardiac anisotropic sheet (hvCAS) is reported. Well-characterized human pluripotent stem-cell-derived ventricular cardiomyocytes are strategically aligned to reproduce key electrophysiological features of native human ventricle, which, along with specific selection criteria, allows for a direct visualization of arrhythmic spiral re-entry and represents a revolutionary tool to assess preclinical drug-induced arrhythmogenicity.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  anisotropy; cell alignments; drug-induced arrhythmias; human pluripotent stem cell-derived ventricular cardiomyocytes; micropatterned monolayers

Mesh：

Year:  2016        PMID： 27805726     DOI： 10.1002/adma.201602448

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  12 in total

1.  Validating the Arrhythmogenic Potential of High-, Intermediate-, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System.

Authors:  Verena Charwat; Bérénice Charrez; Brian A Siemons; Henrik Finsberg; Karoline H Jæger; Andrew G Edwards; Nathaniel Huebsch; Samuel Wall; Evan Miller; Aslak Tveito; Kevin E Healy
Journal:  ACS Pharmacol Transl Sci       Date:  2022-07-29

2.  Nanotopography-responsive myotube alignment and orientation as a sensitive phenotypic biomarker for Duchenne Muscular Dystrophy.

Authors:  Bin Xu; Alessandro Magli; Yoska Anugrah; Steven J Koester; Rita C R Perlingeiro; Wei Shen
Journal:  Biomaterials       Date:  2018-08-21       Impact factor: 12.479

3.  All-Polymer Printed Low-Cost Regenerative Nerve Cuff Electrodes.

Authors:  Laura M Ferrari; Bruno Rodríguez-Meana; Alberto Bonisoli; Annarita Cutrone; Silvestro Micera; Xavier Navarro; Francesco Greco; Jaume Del Valle
Journal:  Front Bioeng Biotechnol       Date:  2021-02-10

Review 4.  Micro- and nanoscale biophysical cues for cardiovascular disease therapy.

Authors:  Priya Mohindra; Tejal A Desai
Journal:  Nanomedicine       Date:  2021-02-09       Impact factor: 6.096

5.  Correlation between frataxin expression and contractility revealed by in vitro Friedreich's ataxia cardiac tissue models engineered from human pluripotent stem cells.

Authors:  Andy On-Tik Wong; Gabriel Wong; Michael Shen; Maggie Zi-Ying Chow; Wan Wai Tse; Bimal Gurung; Suet Yee Mak; Deborah K Lieu; Kevin D Costa; Camie W Chan; Alain Martelli; Joseph F Nabhan; Ronald A Li
Journal:  Stem Cell Res Ther       Date:  2019-07-08       Impact factor: 6.832

Review 6.  Cardiac tissue engineering: state-of-the-art methods and outlook.

Authors:  Anh H Nguyen; Paul Marsh; Lauren Schmiess-Heine; Peter J Burke; Abraham Lee; Juhyun Lee; Hung Cao
Journal:  J Biol Eng       Date:  2019-06-28       Impact factor: 4.355

Review 7.  Cardiac Organoids to Model and Heal Heart Failure and Cardiomyopathies.

Authors:  Magali Seguret; Eva Vermersch; Charlène Jouve; Jean-Sébastien Hulot
Journal:  Biomedicines       Date:  2021-05-18

8.  Combinatorial Treatment of Human Cardiac Engineered Tissues With Biomimetic Cues Induces Functional Maturation as Revealed by Optical Mapping of Action Potentials and Calcium Transients.

Authors:  Andy On-Tik Wong; Nicodemus Wong; Lin Geng; Maggie Zi-Ying Chow; Eugene K Lee; Hongkai Wu; Michelle Khine; Chi-Wing Kong; Kevin D Costa; Wendy Keung; Yiu-Fai Cheung; Ronald A Li
Journal:  Front Physiol       Date:  2020-03-12       Impact factor: 4.566

9.  Single-Cell Transcriptomics of Engineered Cardiac Tissues From Patient-Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome.

Authors:  Yin-Yu Lam; Wendy Keung; Chun-Ho Chan; Lin Geng; Nicodemus Wong; David Brenière-Letuffe; Ronald A Li; Yiu-Fai Cheung
Journal:  J Am Heart Assoc       Date:  2020-10-16       Impact factor: 5.501

Review 10.  Model Systems for Addressing Mechanism of Arrhythmogenesis in Cardiac Repair.

Authors:  Xiao-Dong Zhang; Phung N Thai; Deborah K Lieu; Nipavan Chiamvimonvat
Journal:  Curr Cardiol Rep       Date:  2021-05-29       Impact factor: 2.931
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