Literature DB >> 2780542

Criteria for the validity of clinical trials of treatments of cohorts of cancer patients based on the Hardin Jones principle.

L Pauling1, Z S Herman.   

Abstract

With the assumption of the validity of the Hardin Jones principle that the death rate of members of a homogeneous cohort of cancer patients is constant, three criteria for the validity of clinical trials of cancer treatments are formulated. These criteria are satisfied by most published clinical trials, but one trial was found to violate all three, rendering the validity of its reported results uncertain.

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Year:  1989        PMID： 2780542      PMCID： PMC297944          DOI： 10.1073/pnas.86.18.6835

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  4 in total

1.  Demographic consideration of the cancer problem.

Authors:  H B JONES
Journal:  Trans N Y Acad Sci       Date:  1956-02

2.  Biostatistical analysis of mortality data for cohorts of cancer patients.

Authors:  L Pauling
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

3.  Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.

Authors:  E Cameron; L Pauling
Journal:  Proc Natl Acad Sci U S A       Date:  1976-10       Impact factor: 11.205

4.  High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison.

Authors:  C G Moertel; T R Fleming; E T Creagan; J Rubin; M J O'Connell; M M Ames
Journal:  N Engl J Med       Date:  1985-01-17       Impact factor: 91.245
  4 in total
  1 in total

Review 1.  Bias against Vitamin C in Mainstream Medicine: Examples from Trials of Vitamin C for Infections.

Authors:  Harri Hemilä; Elizabeth Chalker
Journal:  Life (Basel)       Date:  2022-01-03
  1 in total

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