Mark I Ryder1, Tzy-Jyun Yao2, Jonathan S Russell2, Anna-Barbara Moscicki3, Caroline H Shiboski4. 1. Division of Periodontology, Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA. 2. Center for Biostatistics in AIDS Research (CBAR), Harvard T.H. Chan School of Public Health, Boston, MA, USA. 3. Division of Adolescent Medicine, Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA, USA. 4. Division of Oral Medicine, Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA.
Abstract
AIMS: To compare the prevalence and severity of periodontal diseases between 180 perinatally HIV-infected (PHIV) and 118 perinatally HIV-exposed and uninfected (PHEU) youth in a cross-sectional study conducted at 11 clinical sites in the United States and Puerto Rico from the Adolescent Master Protocol study of the Pediatric HIV/AIDS cohort study (PHACS) network. METHODS: Several analyses were conducted, employing the current CDC/AAP classification for periodontitis and incorporating a definition of gingivitis based on a bleeding on probing (BOP) threshold, and analyses based on more detailed whole-mouth, intra-oral regionally, site-based and tooth-based criteria of BOP, plaque levels, pockets depths and clinical attachment levels. RESULTS: After adjusting for plaque control habits and behavioural and sociodemographic factors, there were no significant differences in periodontal diseases between the PHIV and PHEU youth using any of these criteria. For PHIV youth, there was no significant association between parameters of periodontal disease and current HIV status. CONCLUSIONS: Although no significant differences in periodontal parameters were noted between the PHIV and PHEU youth, the influence of antiretroviral therapy merits further exploration in this cohort in a longitudinal study.
AIMS: To compare the prevalence and severity of periodontal diseases between 180 perinatally HIV-infected (PHIV) and 118 perinatally HIV-exposed and uninfected (PHEU) youth in a cross-sectional study conducted at 11 clinical sites in the United States and Puerto Rico from the Adolescent Master Protocol study of the Pediatric HIV/AIDS cohort study (PHACS) network. METHODS: Several analyses were conducted, employing the current CDC/AAP classification for periodontitis and incorporating a definition of gingivitis based on a bleeding on probing (BOP) threshold, and analyses based on more detailed whole-mouth, intra-oral regionally, site-based and tooth-based criteria of BOP, plaque levels, pockets depths and clinical attachment levels. RESULTS: After adjusting for plaque control habits and behavioural and sociodemographic factors, there were no significant differences in periodontal diseases between the PHIV and PHEU youth using any of these criteria. For PHIV youth, there was no significant association between parameters of periodontal disease and current HIV status. CONCLUSIONS: Although no significant differences in periodontal parameters were noted between the PHIV and PHEU youth, the influence of antiretroviral therapy merits further exploration in this cohort in a longitudinal study.
Authors: Lance T Vernon; Denise C Babineau; Catherine A Demko; Michael M Lederman; Xuelei Wang; Zahra Toossi; Aaron Weinberg; Benigno Rodriguez Journal: AIDS Res Hum Retroviruses Date: 2011-05-09 Impact factor: 2.205
Authors: Caroline H Shiboski; Tzy-Jyun Yao; Jonathan S Russell; Mark I Ryder; Russell B Van Dyke; George R Seage; Anna-Barbara Moscicki Journal: AIDS Date: 2018-11-13 Impact factor: 4.177
Authors: Fabian Schulte; Oliver D King; Bruce J Paster; Anna-Barbara Moscicki; Tzy-Jyun Yao; Russell B Van Dyke; Caroline Shiboski; Mark Ryder; George Seage; Markus Hardt Journal: Metabolomics Date: 2020-09-11 Impact factor: 4.290
Authors: Anna-Barbara Moscicki; Tzy-Jyun Yao; Jonathan S Russell; Sepideh Farhat; Mark Scott; Larry Magpantay; Gordana Halec; Caroline H Shiboski; Mark I Ryder Journal: J Clin Periodontol Date: 2019-09-05 Impact factor: 8.728
Authors: Jacqueline R Starr; Yanmei Huang; Kyu Ha Lee; C M Murphy; Anna-Barbara Moscicki; Caroline H Shiboski; Mark I Ryder; Tzy-Jyun Yao; Lina L Faller; Russell B Van Dyke; Bruce J Paster Journal: Microbiome Date: 2018-05-31 Impact factor: 14.650