T T Zhang1, A N Sun, J L Pan, D P Wu, H Y Qiu, X W Tang, M Miao, S N Chen. 1. Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Collaborative Innovation Center of Hematology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Abstract
Objective: To retrospectively analyze the clinical features, cytogenetic characteristics and survival of 550 newly diagnosed myelodysplastic syndrome(MDS)patients. Method: By using WHO(2008)criterion for classification, the prognosis of stratification of 550 patients were evaluated according to the IPSS/WPSS/IPSS-R. Results: The median age was 57 years old(range: 12-89 years old). The ratio of male and female was 1.72. In all patients, the median hemoglobin level was 72(22-154)g/L, the median platelet count was 52(3-587)×109/L and the median WBC was 2.52(0.11-48.00)×109/L. 45.6%(251/550)patients had clonal chromosome abnormalities, in which 89(16.2%)patients with complex karyotype. The types of chromosome aberration were mainly dominated by unbalanced anomalies, and the most common types of chromosome aberration were trisomy or monosomy. The most common abnormity was +8. Other aberrations in frequent order were - 7/del(7q), del(5q), del(20q), and so on. In addition, 550 patients were evaluated according to IPSS, IPSS-R, and WPSS prognostic scoring system. The results showed that the IPSS, WPSS and IPSS-R scores were significantly affected OS(P <0.001). The median OS in the IPSSR Low, Intermediate, High and Very Highrisk groups was not reached, 44(95%CI 28-60), 17(95%CI 13- 21)and 8(95%CI 5-11)months, respectively. Conclusion: In this study, the patients' median age was 57(12- 89)years old, and the cytogenetic characteristics were significantly different from western MDS patients. IPSS, IPSS-R and WPSS were important in predicting the survival of MDS patients.
Objective: To retrospectively analyze the clinical features, cytogenetic characteristics and survival of 550 newly diagnosed myelodysplastic syndrome(MDS)patients. Method: By using WHO(2008)criterion for classification, the prognosis of stratification of 550 patients were evaluated according to the IPSS/WPSS/IPSS-R. Results: The median age was 57 years old(range: 12-89 years old). The ratio of male and female was 1.72. In all patients, the median hemoglobin level was 72(22-154)g/L, the median platelet count was 52(3-587)×109/L and the median WBC was 2.52(0.11-48.00)×109/L. 45.6%(251/550)patients had clonal chromosome abnormalities, in which 89(16.2%)patients with complex karyotype. The types of chromosome aberration were mainly dominated by unbalanced anomalies, and the most common types of chromosome aberration were trisomy or monosomy. The most common abnormity was +8. Other aberrations in frequent order were - 7/del(7q), del(5q), del(20q), and so on. In addition, 550 patients were evaluated according to IPSS, IPSS-R, and WPSS prognostic scoring system. The results showed that the IPSS, WPSS and IPSS-R scores were significantly affected OS(P <0.001). The median OS in the IPSSR Low, Intermediate, High and Very Highrisk groups was not reached, 44(95%CI 28-60), 17(95%CI 13- 21)and 8(95%CI 5-11)months, respectively. Conclusion: In this study, the patients' median age was 57(12- 89)years old, and the cytogenetic characteristics were significantly different from western MDSpatients. IPSS, IPSS-R and WPSS were important in predicting the survival of MDSpatients.
Authors: B Li; J Y Wang; J Q Liu; Z X Shi; S L Peng; H J Huang; T J Qin; Z F Xu; Y Zhang; L W Fang; H L Zhang; N B Hu; L J Pan; S Q Qu; Z J Xiao Journal: Zhonghua Xue Ye Xue Za Zhi Date: 2017-12-14