Literature DB >> 27799213

Morphological Effect of the New Antifungal Agent ME1111 on Hyphal Growth of Trichophyton mentagrophytes, Determined by Scanning and Transmission Electron Microscopy.

Yayoi Nishiyama1, Sho Takahata2, Shigeru Abe3.   

Abstract

The effects of ME1111, a novel antifungal agent, on the hyphal morphology and ultrastructure of Trichophyton mentagrophytes were investigated by using scanning and transmission electron microscopy. Structural changes, such as pit formation and/or depression of the cell surface, and degeneration of intracellular organelles and plasmolysis were observed after treatment with ME1111. Our results suggest that the inhibition of energy production by ME1111 affects the integrity and function of cellular membranes, leading to fungal cell death.
Copyright © 2016 American Society for Microbiology.

Entities:  

Keywords:  antifungal agents; electron microscopy; mode of action; morphology

Mesh：

Substances：

Year:  2016        PMID： 27799213      PMCID： PMC5192111          DOI： 10.1128/AAC.01195-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

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3.  In vitro antifungal activity of ME1111, a new topical agent for onychomycosis, against clinical isolates of dermatophytes.

Authors:  M Ghannoum; N Isham; L Long
Journal:  Antimicrob Agents Chemother       Date:  2015-06-08       Impact factor: 5.191

4.  Multilaboratory Evaluation of In Vitro Antifungal Susceptibility Testing of Dermatophytes for ME1111.

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Journal:  Antimicrob Agents Chemother       Date:  2013-03-04       Impact factor: 5.191

6.  Morphological changes of Candida albicans induced by micafungin (FK463), a water-soluble echinocandin-like lipopeptide.

Authors:  Yayoi Nishiyama; Katsuhisa Uchida; Hideyo Yamaguchi
Journal:  J Electron Microsc (Tokyo)       Date:  2002

7.  Mechanism of Action of ME1111, a Novel Antifungal Agent for Topical Treatment of Onychomycosis.

Authors:  Sho Takahata; Natsuki Kubota; Naomi Takei-Masuda; Tsuyoshi Yamada; Mari Maeda; Mohamed Mahdi Alshahni; Shigeru Abe; Yuji Tabata; Kazunori Maebashi
Journal:  Antimicrob Agents Chemother       Date:  2015-11-23       Impact factor: 5.191

8.  Morphological changes associated with growth inhibition of Trichophyton mentagrophytes by amorolfine.

Authors:  Y Nishiyama; Y Asagi; T Hiratani; H Yamaguchi; N Yamada; M Osumi
Journal:  Clin Exp Dermatol       Date:  1992-09       Impact factor: 3.470

9.  Characterization of Antifungal Activity and Nail Penetration of ME1111, a New Antifungal Agent for Topical Treatment of Onychomycosis.

Authors:  Yuji Tabata; Naomi Takei-Masuda; Natsuki Kubota; Sho Takahata; Makoto Ohyama; Kaori Kaneda; Maiko Iida; Kazunori Maebashi
Journal:  Antimicrob Agents Chemother       Date:  2015-12-07       Impact factor: 5.191

10.  Evaluation of the Efficacy of ME1111 in the Topical Treatment of Dermatophytosis in a Guinea Pig Model.

Authors:  L Long; C Hager; M Ghannoum
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191
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