Aimin Ding1, Guoqing Qiu2, Wensheng Lin2, Ling Hu2, Guangliang Lu2, Xiang Long2, Xin Hong2, Yaohua Chen2, Xiaoping Luo2, Qinqin Tang2, Dongqin Deng2. 1. The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China. 5413dam@163.com. 2. The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China.
Abstract
PURPOSE: Fractional flow reserve based on coronary computed tomographic angiography (CCTA; FFRCT) can evaluate functional severity in coronary artery disease (CAD). This study investigated the diagnostic value of FFRCT for determining CAD severity. MATERIALS AND METHODS: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until June 16, 2016 using the following search terms: fractional flow reserve, coronary computed tomography angiography, myocardial ischemia. Randomized controlled trials, two-arm prospective studies, and retrospective studies were included in the analysis. RESULTS: Twenty-one studies were included with a total of 2216 subjects and 2798 vessels. FFRCT, sensitivity per-vessel and per-patient were ≥82% and specificity was ≥73% for diagnosis of ischemia. FFRCT had better diagnostic accuracy and discrimination than CCTA. CONCLUSION: This study indicates that FFRCT may be a good tool for screening and diagnosing of myocardial ischemia in patients with CAD.
PURPOSE: Fractional flow reserve based on coronary computed tomographic angiography (CCTA; FFRCT) can evaluate functional severity in coronary artery disease (CAD). This study investigated the diagnostic value of FFRCT for determining CAD severity. MATERIALS AND METHODS: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until June 16, 2016 using the following search terms: fractional flow reserve, coronary computed tomography angiography, myocardial ischemia. Randomized controlled trials, two-arm prospective studies, and retrospective studies were included in the analysis. RESULTS: Twenty-one studies were included with a total of 2216 subjects and 2798 vessels. FFRCT, sensitivity per-vessel and per-patient were ≥82% and specificity was ≥73% for diagnosis of ischemia. FFRCT had better diagnostic accuracy and discrimination than CCTA. CONCLUSION: This study indicates that FFRCT may be a good tool for screening and diagnosing of myocardial ischemia in patients with CAD.
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