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Literature DB >> 27796148

The potential use of urine cell free DNA as a marker for cancer.

Samanta Salvi¹, Filippo Martignano¹, Chiara Molinari¹, Giorgia Gurioli¹, Daniele Calistri¹, Ugo De Giorgi², Vincenza Conteduca², Valentina Casadio¹.

Abstract

INTRODUCTION: Although the role of circulating cell free DNA in cancer has been widely demonstrated, less is known about the role of urine cell free DNA (UcfDNA). UcfDNA can serve as a 'liquid biopsy' for urological and non-urological tumors, as it carries information on DNA from cells exfoliated in urine and from circulation. Areas covered: We review the studies on UcfDNA as a source of biomarkers for cancer, focusing on the new techniques and the differences between urological and non-urological tumors. We searched Pubmed for articles published between 1998 and 2016 with the following key words and phrases: 'urine' and 'cell free DNA' or 'liquid biopsy' or 'cancer'. Expert commentary: Despite the few papers published on this topic, UcfDNA is an important component of 'liquid biopsy', a useful and non-invasive tool for cancer diagnosis, prognosis and treatment monitoring, containing a wide range of genetic information.

Entities: Disease

Keywords: Urine; cancer; cell free DNA; liquid biopsy; markers

Mesh：

Substances：

Year: 2016 PMID： 27796148 DOI： 10.1080/14737159.2016.1254551

Source DB: PubMed Journal: Expert Rev Mol Diagn ISSN： 1473-7159 Impact factor: 5.225

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Cited

13 in total

1. Utility of liquid biopsy using urine in patients with pancreatic ductal adenocarcinoma.

Authors: Hiroyuki Terasawa; Hideaki Kinugasa; Soichiro Ako; Mami Hirai; Hiroshi Matsushita; Daisuke Uchida; Takeshi Tomoda; Kazuyuki Matsumoto; Shigeru Horiguchi; Hironari Kato; Kazuhiro Nouso; Hiroyuki Okada
Journal: Cancer Biol Ther Date: 2019-07-22 Impact factor: 4.742

2. [Urinary long non-coding RNA H19 may serve as a biomarker for early diagnosis of acute intestinal necrosis].

Authors: Yulei Dai; Lubin Yan; Jieling Fan; Qi Zou
Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2018-07-30

Review 3. Current and Emerging Applications of Droplet Digital PCR in Oncology.

Authors: Susana Olmedillas-López; Mariano García-Arranz; Damián García-Olmo
Journal: Mol Diagn Ther Date: 2017-10 Impact factor: 4.074

4. 6-gene promoter methylation assay is potentially applicable for prostate cancer clinical staging based on urine collection following prostatic massage.

Authors: Kostyantyn A Nekrasov; Mark V Vikarchuk; Evgeniya E Rudenko; Igor V Ivanitskiy; Viacheslav M Grygorenko; Rostyslav O Danylets; Alexander G Kondratov; Liubov A Stoliar; Bizhan R Sharopov; Volodymyr I Kashuba
Journal: Oncol Lett Date: 2019-10-29 Impact factor: 2.967

The potential use of urine cell free DNA as a marker for cancer.

1. Utility of liquid biopsy using urine in patients with pancreatic ductal adenocarcinoma.

2. [Urinary long non-coding RNA H19 may serve as a biomarker for early diagnosis of acute intestinal necrosis].

Review 3. Current and Emerging Applications of Droplet Digital PCR in Oncology.

4. 6-gene promoter methylation assay is potentially applicable for prostate cancer clinical staging based on urine collection following prostatic massage.

Review 5. Urinary Biomarkers in Tumors: An Overview.

Review 6. Clinical applications of urinary cell-free DNA in cancer: current insights and promising future.

Review 7. Toward urinary cell-free DNA-based treatment of urothelial carcinoma: a narrative review.

Review 8. Kinetics of circulating cell-free DNA for biomedical applications: critical appraisal of the literature.

Review 9. Urine as a Source of Liquid Biopsy for Cancer.

10. Urine cell-free DNA as a promising biomarker for early detection of non-small cell lung cancer.