Literature DB >> 27795696

Design and Validation of a Vacuum Assisted Anchorage for the Uniaxial Tensile Testing of Soft Materials.

Kory J Blose1, Joseph E Pichamuthu2, Justin S Weinbaum3, David A Vorp4.   

Abstract

Current commercial tensile testing systems use spring-loaded or other compression-based grips to clamp materials in place posing a problem for very soft or delicate materials that cannot withstand this mechanical clamping force. In order to perform uniaxial tensile tests on soft tissues or materials, we have created a novel vacuum-assisted anchor (VAA). Fibrin gels were subjected to uniaxial extension, and the testing data was used to determine material mechanical properties. Utilizing the VAA, we achieved successful tensile breaks of soft fibrin gels while finding statistically significant differences between the mechanical properties of gels fabricated at two different fibrinogen concentrations.

Entities:  

Keywords:  elastic modulus; failure; fibrin; soft materials; tensile testing; tissue grip

Year:  2016        PMID: 27795696      PMCID: PMC5082747          DOI: 10.1080/1539445X.2016.1141787

Source DB:  PubMed          Journal:  Soft Mater        ISSN: 1539-445X            Impact factor:   2.429


  20 in total

1.  Mechanical stimulation induces morphological and phenotypic changes in bone marrow-derived progenitor cells within a three-dimensional fibrin matrix.

Authors:  Alejandro Nieponice; Timothy M Maul; Joy M Cumer; Lorenzo Soletti; David A Vorp
Journal:  J Biomed Mater Res A       Date:  2007-06-01       Impact factor: 4.396

2.  Cyclic distension of fibrin-based tissue constructs: evidence of adaptation during growth of engineered connective tissue.

Authors:  Zeeshan H Syedain; Justin S Weinberg; Robert T Tranquillo
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-24       Impact factor: 11.205

3.  Mechanical and structural contribution of non-fibrillar matrix in uniaxial tension: a collagen-agarose co-gel model.

Authors:  Spencer P Lake; Victor H Barocas
Journal:  Ann Biomed Eng       Date:  2011-03-18       Impact factor: 3.934

4.  Structural origins of fibrin clot rheology.

Authors:  E A Ryan; L F Mockros; J W Weisel; L Lorand
Journal:  Biophys J       Date:  1999-11       Impact factor: 4.033

5.  Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels.

Authors:  Stephanie J Bryant; Kristi S Anseth
Journal:  J Biomed Mater Res       Date:  2002-01

6.  Thermoelasticity of large lecithin bilayer vesicles.

Authors:  R Kwok; E Evans
Journal:  Biophys J       Date:  1981-09       Impact factor: 4.033

7.  Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels.

Authors:  R L Mauck; M A Soltz; C C Wang; D D Wong; P H Chao; W B Valhmu; C T Hung; G A Ateshian
Journal:  J Biomech Eng       Date:  2000-06       Impact factor: 2.097

8.  Implantable arterial grafts from human fibroblasts and fibrin using a multi-graft pulsed flow-stretch bioreactor with noninvasive strength monitoring.

Authors:  Zeeshan H Syedain; Lee A Meier; Jason W Bjork; Ann Lee; Robert T Tranquillo
Journal:  Biomaterials       Date:  2010-10-08       Impact factor: 12.479

9.  Functional tissue-engineered valves from cell-remodeled fibrin with commissural alignment of cell-produced collagen.

Authors:  Paul S Robinson; Sandra L Johnson; Michael C Evans; Victor H Barocas; Robert T Tranquillo
Journal:  Tissue Eng Part A       Date:  2008-01       Impact factor: 3.845

10.  Material properties in unconfined compression of human nucleus pulposus, injectable hyaluronic acid-based hydrogels and tissue engineering scaffolds.

Authors:  Jordan M Cloyd; Neil R Malhotra; Lihui Weng; Weiliam Chen; Robert L Mauck; Dawn M Elliott
Journal:  Eur Spine J       Date:  2007-07-28       Impact factor: 3.134

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  2 in total

1.  Extracellular Vesicles Derived from Primary Adipose Stromal Cells Induce Elastin and Collagen Deposition by Smooth Muscle Cells within 3D Fibrin Gel Culture.

Authors:  Eoghan M Cunnane; Aneesh K Ramaswamy; Katherine L Lorentz; David A Vorp; Justin S Weinbaum
Journal:  Bioengineering (Basel)       Date:  2021-04-27

2.  Adipose-derived stromal cell secreted factors induce the elastogenesis cascade within 3D aortic smooth muscle cell constructs.

Authors:  Aneesh K Ramaswamy; Rachel E Sides; Eoghan M Cunnane; Katherine L Lorentz; Leila M Reines; David A Vorp; Justin S Weinbaum
Journal:  Matrix Biol Plus       Date:  2019-09-04
  2 in total

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