Hugh C Hendrie1, Mengjie Zheng2, Wei Li3, Kathleen Lane2, Roberta Ambuehl4, Christianna Purnell5, Frederick W Unverzagt6, Alexia Torke7, Ashok Balasubramanyam8, Chris M Callahan7, Sujuan Gao2. 1. Indiana University Center for Aging Research, Indianapolis, IN, USA; Regenstrief Institute, Inc., Indianapolis, IN, USA; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: hhendri@iupui.edu. 2. Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA. 3. School of Health and Rehabilitation Sciences, IUPUI, Indianapolis, IN, USA. 4. Regenstrief Institute, Inc., Indianapolis, IN, USA. 5. Indiana University Center for Aging Research, Indianapolis, IN, USA. 6. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA. 7. Indiana University Center for Aging Research, Indianapolis, IN, USA; Regenstrief Institute, Inc., Indianapolis, IN, USA; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. 8. Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Abstract
INTRODUCTION: High blood glucose levels may be responsible for the increased risk for dementia in diabetic patients. METHODS: A secondary data analysis merging electronic medical records (EMRs) with data collected from the Indianapolis-Ibadan Dementia project (IIDP). Of the enrolled 4105 African Americans, 3778 were identified in the EMR. Study endpoints were dementia, mild cognitive impairment (MCI), or normal cognition. Repeated serum glucose measurements were used as the outcome variables. RESULTS: Diabetic participants who developed incident dementia had a significant decrease in serum glucose levels in the years preceding the diagnosis compared to the participants with normal cognition (P = .0002). They also had significantly higher glucose levels up to 9 years before the dementia diagnosis (P = .0367). DISCUSSION: High glucose levels followed by a decline occurring years before diagnosis in African American participants with diabetes may represent a powerful presymptomatic metabolic indicator of dementia.
INTRODUCTION: High blood glucose levels may be responsible for the increased risk for dementia in diabeticpatients. METHODS: A secondary data analysis merging electronic medical records (EMRs) with data collected from the Indianapolis-Ibadan Dementia project (IIDP). Of the enrolled 4105 African Americans, 3778 were identified in the EMR. Study endpoints were dementia, mild cognitive impairment (MCI), or normal cognition. Repeated serum glucose measurements were used as the outcome variables. RESULTS:Diabeticparticipants who developed incident dementia had a significant decrease in serum glucose levels in the years preceding the diagnosis compared to the participants with normal cognition (P = .0002). They also had significantly higher glucose levels up to 9 years before the dementia diagnosis (P = .0367). DISCUSSION: High glucose levels followed by a decline occurring years before diagnosis in African American participants with diabetes may represent a powerful presymptomatic metabolic indicator of dementia.
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