Hugh C Hendrie1, Mengjie Zheng2, Kathleen A Lane2, Roberta Ambuehl3, Christianna Purnell4, Shanshan Li2, Frederick W Unverzagt5, Michael D Murray6, Ashok Balasubramanyam7, Chris M Callahan8, Sujuan Gao2. 1. Indiana University Center for Aging Research, Indianapolis, IN, USA; Regenstrief Institute, Inc., Indianapolis, IN, USA; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: hhendri@iupui.edu. 2. Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA. 3. Regenstrief Institute, Inc., Indianapolis, IN, USA. 4. Indiana University Center for Aging Research, Indianapolis, IN, USA. 5. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA. 6. Regenstrief Institute, Inc., Indianapolis, IN, USA; Purdue University College of Pharmacy, Indianapolis, IN, USA. 7. Department of Medicine, Baylor College of Medicine, Houston, TX, USA. 8. Indiana University Center for Aging Research, Indianapolis, IN, USA; Regenstrief Institute, Inc., Indianapolis, IN, USA; Department of Medicine, Indiana University School of Medicine, Houston, TX, USA.
Abstract
INTRODUCTION: Changes in glucose levels may represent a powerful metabolic indicator of dementia in African-Americans with diabetes. It is unclear whether these changes also occur in Caucasians. METHODS: A secondary data analysis using electronic medical records from 5228 African-Americans and Caucasians aged ≥65 years was carried out. Mixed effects models with repeated serum glucose measurements were used to compare changes in glucose levels between African-Americans and Caucasian patients with and without incident dementia. RESULTS: African-Americans and Caucasians with diabetes had significantly different changes in glucose levels by dementia status (P < .0001). African-Americans experienced a significant decline in glucose levels before the dementia diagnosis (estimated glucose decline 1.3421 mg/dL per year, P < .0001) than those who did not develop dementia. Caucasians with and without dementia showed stable glucose levels over time (P = .3071). DISCUSSION: Significant changes in glucose levels precede dementia in African-American patients with diabetes but not in Caucasians.
INTRODUCTION: Changes in glucose levels may represent a powerful metabolic indicator of dementia in African-Americans with diabetes. It is unclear whether these changes also occur in Caucasians. METHODS: A secondary data analysis using electronic medical records from 5228 African-Americans and Caucasians aged ≥65 years was carried out. Mixed effects models with repeated serum glucose measurements were used to compare changes in glucose levels between African-Americans and Caucasian patients with and without incident dementia. RESULTS: African-Americans and Caucasians with diabetes had significantly different changes in glucose levels by dementia status (P < .0001). African-Americans experienced a significant decline in glucose levels before the dementia diagnosis (estimated glucose decline 1.3421 mg/dL per year, P < .0001) than those who did not develop dementia. Caucasians with and without dementia showed stable glucose levels over time (P = .3071). DISCUSSION: Significant changes in glucose levels precede dementia in African-American patients with diabetes but not in Caucasians.
Authors: Hugh C Hendrie; Donald Lindgren; Donald P Hay; Kathleen A Lane; Sujuan Gao; Christianna Purnell; Stephanie Munger; Faye Smith; Jeanne Dickens; Malaz A Boustani; Christopher M Callahan Journal: Am J Geriatr Psychiatry Date: 2013-02-06 Impact factor: 4.105
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