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Literature DB >> 27793599

A Disease or Not a Disease? Aging As a Pathology.

Timothy V Gladyshev¹, Vadim N Gladyshev².

Abstract

The debate on the relationship between aging and disease is centered on whether aging is a normal/natural/physiological process or it represents a pathology. Considering this relationship from medical, molecular, social, and historical perspectives, we argue that aging is neither a disease, nor a non-disease. Instead, it combines all age-related diseases and their preclinical forms, in addition to other pathological changes. Copyright Â

Entities: Chemical Disease Species

Keywords: aging; disease; pathology

Mesh：

Year: 2016 PMID： 27793599 PMCID： PMC5540438 DOI： 10.1016/j.molmed.2016.09.009

Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951

9 in total

1. The not-so-close relationship between biological aging and age-associated pathologies in humans.

Authors: Leonard Hayflick
Journal: J Gerontol A Biol Sci Med Sci Date: 2004-06 Impact factor: 6.053

Review 2. The genetics of ageing.

Authors: Cynthia J Kenyon
Journal: Nature Date: 2010-03-25 Impact factor: 49.962

Review 3. Aging is not a disease: implications for intervention.

Authors: Suresh I S Rattan
Journal: Aging Dis Date: 2014-06-01 Impact factor: 6.745

4. The worldwide epidemiology of prostate cancer: perspectives from autopsy studies.

Authors: Gabriel P Haas; Nicolas Delongchamps; Otis W Brawley; Ching Y Wang; Gustavo de la Roza
Journal: Can J Urol Date: 2008-02 Impact factor: 1.344

Review 5. Interventions to Slow Aging in Humans: Are We Ready?

Authors: Valter D Longo; Adam Antebi; Andrzej Bartke; Nir Barzilai; Holly M Brown-Borg; Calogero Caruso; Tyler J Curiel; Rafael de Cabo; Claudio Franceschi; David Gems; Donald K Ingram; Thomas E Johnson; Brian K Kennedy; Cynthia Kenyon; Samuel Klein; John J Kopchick; Guenter Lepperdinger; Frank Madeo; Mario G Mirisola; James R Mitchell; Giuseppe Passarino; Karl L Rudolph; John M Sedivy; Gerald S Shadel; David A Sinclair; Stephen R Spindler; Yousin Suh; Jan Vijg; Manlio Vinciguerra; Luigi Fontana
Journal: Aging Cell Date: 2015-04-22 Impact factor: 9.304

Review 6. The aging-disease false dichotomy: understanding senescence as pathology.

Authors: David Gems
Journal: Front Genet Date: 2015-06-16 Impact factor: 4.599

7. Entropy explains aging, genetic determinism explains longevity, and undefined terminology explains misunderstanding both.

Authors: Leonard Hayflick
Journal: PLoS Genet Date: 2007-12 Impact factor: 5.917

8. Should we treat aging as a disease? The consequences and dangers of miscategorisation.

Authors: Richard G A Faragher
Journal: Front Genet Date: 2015-07-14 Impact factor: 4.599

Review 9. Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes.

Authors: Vadim N Gladyshev
Journal: Aging Cell Date: 2016-04-06 Impact factor: 9.304

9 in total

14 in total

1. Human neurons to model aging: A dish best served old.

Authors: Lena Böhnke; Larissa Traxler; Joseph R Herdy; Jerome Mertens
Journal: Drug Discov Today Dis Models Date: 2019-02-12

2. Frequency, Recognition, and Potential Risk Factors of Incidental Findings on Trauma Computed Tomography Scans: A Cross-Sectional Study at an Urban Level One Trauma Center.

Authors: Wei-An Lai; Pang-Hsu Liu; Ming-Jen Tsai; Ying Chieh Huang
Journal: J Acute Med Date: 2020-09-01

A Disease or Not a Disease? Aging As a Pathology.

1. The not-so-close relationship between biological aging and age-associated pathologies in humans.

Review 2. The genetics of ageing.

Review 3. Aging is not a disease: implications for intervention.

4. The worldwide epidemiology of prostate cancer: perspectives from autopsy studies.

Review 5. Interventions to Slow Aging in Humans: Are We Ready?

Review 6. The aging-disease false dichotomy: understanding senescence as pathology.

7. Entropy explains aging, genetic determinism explains longevity, and undefined terminology explains misunderstanding both.

8. Should we treat aging as a disease? The consequences and dangers of miscategorisation.

Review 9. Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes.

1. Human neurons to model aging: A dish best served old.

2. Frequency, Recognition, and Potential Risk Factors of Incidental Findings on Trauma Computed Tomography Scans: A Cross-Sectional Study at an Urban Level One Trauma Center.

3. How size and genetic diversity shape lifespan across breeds of purebred dogs.

Review 4. Functional mechanisms and abnormalities of the nuclear lamina.

Review 5. The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates.

6. Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO.

7. Antiaging effect of a Jianpi-yangwei formula in Caenorhabditis elegans.

8. Effect of young exosomes injected in aged mice.

Review 9. Brain age and other bodily 'ages': implications for neuropsychiatry.

10. Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity.