Rebecca M Schwartz1, Rowena Yip2, Raja M Flores3, Ingram Olkin4, Emanuela Taioli5, Claudia Henschke2. 1. Department of Occupational Medicine, Epidemiology and Prevention (OMEP), Hofstra Northwell School of Medicine, Great Neck, New York. 2. Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, New York. 3. Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, New York. 4. Department of Statistics, Stanford University, Stanford, California. 5. Population Health Science and Policy Department and Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, New York.
Abstract
BACKGROUND AND OBJECTIVES: Given the increased number of treatment options for stage IA lung cancer patients, there is a growing body of literature that focuses on comparing each option's relative impact on quality of life (QoL). The current study seeks to further understand the differences in these patients' QoL according to surgical approach. METHODS: Screening-diagnosed first primary pathologic stage IA non-small-cell lung cancer surgical patients from the I-ELCAP cohort who answered a baseline and 1-year follow-up QoL questionnaire (SF-12) were included in the analysis. Thoracotomy patients (N = 85) were compared with VATS patients (N = 15) using paired t-tests and analysis of variance tests. RESULTS: Multivariate analyses indicated no differences in QoL change between the two groups from pre- to post-surgery. Physical and emotional role functioning significantly improved among VATS patients and worsened among thoracotomy patients. Among thoracotomy patients, a significant decrease in post-surgical physical QoL was observed only in those who underwent lobectomy (-3.3; 95% CI: -5.1,-1.5), not limited resection. CONCLUSIONS: Although the sample size is small, preliminary findings underscore that changes in overall QoL are similar in VATS and thoracotomy stage IA lung cancer patients. Extension of the resection may be a more relevant factor on QoL post-surgery. J. Surg. Oncol. 2017;115:173-180.
BACKGROUND AND OBJECTIVES: Given the increased number of treatment options for stage IA lung cancerpatients, there is a growing body of literature that focuses on comparing each option's relative impact on quality of life (QoL). The current study seeks to further understand the differences in these patients' QoL according to surgical approach. METHODS: Screening-diagnosed first primary pathologic stage IA non-small-cell lung cancer surgical patients from the I-ELCAP cohort who answered a baseline and 1-year follow-up QoL questionnaire (SF-12) were included in the analysis. Thoracotomy patients (N = 85) were compared with VATS patients (N = 15) using paired t-tests and analysis of variance tests. RESULTS: Multivariate analyses indicated no differences in QoL change between the two groups from pre- to post-surgery. Physical and emotional role functioning significantly improved among VATS patients and worsened among thoracotomy patients. Among thoracotomy patients, a significant decrease in post-surgical physical QoL was observed only in those who underwent lobectomy (-3.3; 95% CI: -5.1,-1.5), not limited resection. CONCLUSIONS: Although the sample size is small, preliminary findings underscore that changes in overall QoL are similar in VATS and thoracotomy stage IA lung cancerpatients. Extension of the resection may be a more relevant factor on QoL post-surgery. J. Surg. Oncol. 2017;115:173-180.
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