Krishnappriya Ramachandran1, Sathish Kumar Mani2, Gopinath Kango Gopal3, Srinivasan Rangasami4. 1. Assistant Professor, Department of Respiratory Medicine, Meenakshi Medical College Hospital and Research Institute , Kanchipuram, Tamil Nadu, India . 2. Senior Resident, Department of Respiratory Medicine, Saveetha Medical College , Chennai, Tamil Nadu, India . 3. Professor, Department of Geriatrics, Christian Medical College and Hospital , Vellore, Tamil Nadu, India . 4. Professor, Department of Respiratory Medicine, Meenakshi Medical College Hospital and Research Institute , Kanchipuram, Tamil Nadu, India.
Abstract
INTRODUCTION: Chronic Obstructive Pulmonary Disease (COPD) is a disease of wasting with airflow limitation, associated with a variety of systemic manifestations such as reduced Bone Mineral Density (BMD). There is a paucity of Indian studies on the effects of COPD on BMD. AIM: This study was conducted to estimate the prevalence of osteopenia and osteoporosis in COPD patients and the correlation between bone density and severity of COPD classified according to GOLD Global initiative for chronic Obstructive Lung Disease guidelines (GOLD). MATERIALS AND METHODS: A prospective study of 60 patients diagnosed to have COPD, was conducted in the outpatient department of Respiratory Medicine, at a tertiary care hospital in Southern India, between September 2012 and September 2013. BMD was measured using ultrasound bone densitometer (ACHILLES GE HEALTH CARE). Patients with a T-score between -1 and -2.5 were considered to be osteopenic while patients with a T score less than -2.5 were considered to be osteoporotic (WHO criteria). RESULTS: Overall, 40 (67%) patients had an abnormal bone mineral density. A total of 21 (35%) patients were osteoporotic while 19 (33%) were osteopenic. BMD levels correlated with severity of obstruction (p<0.001), smoking status (p=0.02), age (p=0.05) and number of pack years (p=0.001). CONCLUSION: Patients with COPD are at an increased risk for lower BMD and osteoporotic fractures and the risk appears to increase with disease severity. Further studies are required to assess whether routine BMD measurements in COPD patients is beneficial to diagnose osteoporosis and reduce morbidity.
INTRODUCTION:Chronic Obstructive Pulmonary Disease (COPD) is a disease of wasting with airflow limitation, associated with a variety of systemic manifestations such as reduced Bone Mineral Density (BMD). There is a paucity of Indian studies on the effects of COPD on BMD. AIM: This study was conducted to estimate the prevalence of osteopenia and osteoporosis in COPDpatients and the correlation between bone density and severity of COPD classified according to GOLD Global initiative for chronic Obstructive Lung Disease guidelines (GOLD). MATERIALS AND METHODS: A prospective study of 60 patients diagnosed to have COPD, was conducted in the outpatient department of Respiratory Medicine, at a tertiary care hospital in Southern India, between September 2012 and September 2013. BMD was measured using ultrasound bone densitometer (ACHILLES GE HEALTH CARE). Patients with a T-score between -1 and -2.5 were considered to be osteopenic while patients with a T score less than -2.5 were considered to be osteoporotic (WHO criteria). RESULTS: Overall, 40 (67%) patients had an abnormal bone mineral density. A total of 21 (35%) patients were osteoporotic while 19 (33%) were osteopenic. BMD levels correlated with severity of obstruction (p<0.001), smoking status (p=0.02), age (p=0.05) and number of pack years (p=0.001). CONCLUSION:Patients with COPD are at an increased risk for lower BMD and osteoporotic fractures and the risk appears to increase with disease severity. Further studies are required to assess whether routine BMD measurements in COPDpatients is beneficial to diagnose osteoporosis and reduce morbidity.
Authors: J Compston; A Cooper; C Cooper; R Francis; J A Kanis; D Marsh; E V McCloskey; D M Reid; P Selby; M Wilkins Journal: Maturitas Date: 2009-01-08 Impact factor: 4.342
Authors: Lidwien Graat-Verboom; Martijn A Spruit; Ben E E M van den Borne; Frank W J M Smeenk; Elisabeth J Martens; Ragnar Lunde; Emiel F M Wouters Journal: Respir Med Date: 2009-08 Impact factor: 3.415