Literature DB >> 27787838

A Clinical Perspective: Contribution of Dysfunctional Perivascular Adipose Tissue (PVAT) to Cardiovascular Risk.

Xiaoming Lian1, Maik Gollasch2,3.   

Abstract

Perivascular adipose tissue (PVAT) is now recognized as an important paracrine organ influencing the homeostasis of the vessel wall, regional blood flow and peripheral arterial resistance. There is remarkable phenotypic variability and plasticity of PVAT among various vascular beds, exhibiting phenotypes from white to brown and beige adipocytes. PVAT dysfunction is characterized by disturbed secretion of various adipokines, which, together with endothelial dysfunction, contribute to hypertension and cardiovascular disease (CVD). This brief review describes our current knowledge on PVAT in health and cardiovascular disease, with a special focus on different phenotypes and signaling pathways in adipocytes of PVAT associated with hypertension, obesity and cardiovascular disorders.

Entities:  

Keywords:  KCNQ-type KV7 channels; Perivascular relaxing factors, PVRFs; adipocyte-derived relaxing factor, ADRF; adiponectin; beige adipocytes; hydrogen sulfide, H2S

Mesh：

Substances：

Year:  2016        PMID： 27787838     DOI： 10.1007/s11906-016-0692-z

Source DB:  PubMed          Journal:  Curr Hypertens Rep        ISSN： 1522-6417            Impact factor:   5.369


  114 in total

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Review 2.  Perivascular adipose tissue, inflammation and vascular dysfunction in obesity.

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3.  The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation.

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Journal:  Am J Physiol Endocrinol Metab       Date:  2010-03-30       Impact factor: 4.310

Review 4.  Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: a need for screening tools to target interventions.

Authors:  Mark D DeBoer
Journal:  Nutrition       Date:  2012-09-28       Impact factor: 4.008

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Authors:  Liming Yu; Qisheng Tu; Qianqian Han; Lan Zhang; Lei Sui; Leilei Zheng; Shu Meng; Yin Tang; Dongying Xuan; Jin Zhang; Dana Murray; Qingping Shen; Jessica Cheng; Sung-Hoon Kim; Lily Q Dong; Paloma Valverde; Xinming Cao; Jake Chen
Journal:  Stem Cells       Date:  2015-01       Impact factor: 6.277

Review 6.  Functional Relationship between Arterial Tissue and Perivascular Adipose Tissue in Metabolic Syndrome.

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7.  Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells.

Authors:  Daniel J Cavanaugh; Alexander T Chesler; Alexander C Jackson; Yaron M Sigal; Hiroki Yamanaka; Rebecca Grant; Dajan O'Donnell; Roger A Nicoll; Nirao M Shah; David Julius; Allan I Basbaum
Journal:  J Neurosci       Date:  2011-03-30       Impact factor: 6.167

Review 8.  Adipokines in inflammation and metabolic disease.

Authors:  Noriyuki Ouchi; Jennifer L Parker; Jesse J Lugus; Kenneth Walsh
Journal:  Nat Rev Immunol       Date:  2011-01-21       Impact factor: 53.106

Review 9.  Adipokines in human reproduction.

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Journal:  Hypertension       Date:  2012-11-26       Impact factor: 10.190
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  13 in total

1.  Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women: The SWAN Cardiovascular Fat Ancillary Study.

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Journal:  J Gerontol A Biol Sci Med Sci       Date:  2019-11-13       Impact factor: 6.053

Review 2.  PVAT: an important guardian of the cardiovascular system.

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Journal:  Histol Histopathol       Date:  2020-02-21       Impact factor: 2.303

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Review 4.  Perivascular Adipose Tissue Regulates Vascular Function by Targeting Vascular Smooth Muscle Cells.

Authors:  Lin Chang; Minerva T Garcia-Barrio; Y Eugene Chen
Journal:  Arterioscler Thromb Vasc Biol       Date:  2020-03-19       Impact factor: 8.311

Review 5.  Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension.

Authors:  Natalia Jorgelina Prado; León Ferder; Walter Manucha; Emiliano Raúl Diez
Journal:  Curr Hypertens Rep       Date:  2018-05-09       Impact factor: 5.369

Review 6.  Hydrogen sulfide and vascular regulation - An update.

Authors:  Boyang Lv; Selena Chen; Chaoshu Tang; Hongfang Jin; Junbao Du; Yaqian Huang
Journal:  J Adv Res       Date:  2020-05-16       Impact factor: 10.479

7.  DNA methylation profile of genes involved in inflammation and autoimmunity correlates with vascular function in morbidly obese adults.

Authors:  Mohamed M Ali; Dina Naquiallah; Maryam Qureshi; Mohammed Imaduddin Mirza; Chandra Hassan; Mario Masrur; Francesco M Bianco; Patrice Frederick; Giulianotti P Cristoforo; Antonio Gangemi; Shane A Phillips; Abeer M Mahmoud
Journal:  Epigenetics       Date:  2021-01-25       Impact factor: 4.528

Review 8.  The Kv7 Channel and Cardiovascular Risk Factors.

Authors:  Andreas L Fosmo; Øyvind B Skraastad
Journal:  Front Cardiovasc Med       Date:  2017-12-05

9.  RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gαi2-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway.

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10.  HIF1α/TET1 Pathway Mediates Hypoxia-Induced Adipocytokine Promoter Hypomethylation in Human Adipocytes.

Authors:  Mohamed M Ali; Shane A Phillips; Abeer M Mahmoud
Journal:  Cells       Date:  2020-01-06       Impact factor: 6.600
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