Literature DB >> 27786403

Methotrexate hypersensitivity reactions in pediatrics: Evaluation and management.

Meredith A Dilley1,2, Joyce P Lee1, Ana Dioun Broyles1,2.   

Abstract

Reports of hypersensitivity reactions (HSRs) to MTX are limited to single case studies. We retrospectively reviewed HSRs to MTX during a 12-year period in our tertiary care pediatric center. Seven patients were evaluated for HSRs to MTX. Skin testing was positive in one of the four patients tested. One patient underwent successful graded challenge to MTX. Seventeen desensitizations to MTX were successfully performed in the other six patients. Skin testing, graded challenge, and desensitization were safe and effective procedures in the evaluation and management of patients with HSRs to MTX in our pediatric population.
© 2016 Wiley Periodicals, Inc.

Entities:  

Keywords:  chemotherapy; desensitization; drug allergy; methotrexate

Mesh：

Substances：

Year:  2016        PMID： 27786403      PMCID： PMC5366073          DOI： 10.1002/pbc.26306

Source DB:  PubMed          Journal:  Pediatr Blood Cancer        ISSN： 1545-5009            Impact factor:   3.167


  18 in total

1.  Anaphylactoid reaction to high-dose methotrexate and successful desensitization.

Authors:  Ignacio Oulego-Erroz; Mercedes Maneiro-Freire; Marta Bouzón-Alejandro; Manuel Vázquez-Donsión; José Miguel Couselo
Journal:  Pediatr Blood Cancer       Date:  2010-09       Impact factor: 3.167

2.  Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge.

Authors:  Andrew J MacGinnitie; Loren D Walensky; Stuart E Turvey; Jordan S Orange; Francisco A Bonilla; Lewis B Silverman; Hans Oettgen
Journal:  Pediatr Allergy Immunol       Date:  2003-10       Impact factor: 6.377

3.  Hypersensitivity reaction to high-dose methotrexate and successful rechallenge in a pediatric patient with osteosarcoma.

Authors:  Jeffrey R Scott; Deborah A Ward; Kristine R Crews; John C Panetta; Fariba Navid
Journal:  Pediatr Blood Cancer       Date:  2013-08-19       Impact factor: 3.167

4.  Readministration of high-dose methotrexate in a patient with suspected immediate hypersensitivity and T-cell acute lymphoblastic lymphoma.

Authors:  Anita Kohli; Thomas M Ferencz; Jose G Calderon
Journal:  Allergy Asthma Proc       Date:  2004 Jul-Aug       Impact factor: 2.587

5.  Management and successful desensitization in methotrexate-induced anaphylaxis.

Authors:  Karim Bouchireb; Aurélie Dodille; Claude Ponvert; François Gouraud; Marie Dubrel; Laurence Brugières
Journal:  Pediatr Blood Cancer       Date:  2009-02       Impact factor: 3.167

6.  Anaphylactoid reaction to high-dose methotrexate and re-administration after a successful desensitization.

Authors:  Teresa Caldeira; Vitor Costa; Isabel Silva; Tereza Oliva; Lucília Norton
Journal:  Pediatr Hematol Oncol       Date:  2008-03       Impact factor: 1.969

7.  Successful desensitization to high-dose methotrexate after systemic anaphylaxis.

Authors:  Kepler A Davis; Patrick Williams; John C Walker
Journal:  Ann Allergy Asthma Immunol       Date:  2003-01       Impact factor: 6.347

8.  Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases.

Authors:  Mariana C Castells; Nichole M Tennant; David E Sloane; F Ida Hsu; Nora A Barrett; David I Hong; Tanya M Laidlaw; Henry J Legere; Samridhi N Nallamshetty; Ross I Palis; Jayanti J Rao; Suzanne T Berlin; Susana M Campos; Ursula A Matulonis
Journal:  J Allergy Clin Immunol       Date:  2008-05-27       Impact factor: 10.793

Review 9.  Incidence, clinical features and management of hypersensitivity reactions to chemotherapeutic drugs in children with cancer.

Authors:  Antonio Ruggiero; Silvia Triarico; Giovanna Trombatore; Andrea Battista; Fabiola Dell'acqua; Carmelo Rizzari; Riccardo Riccardi
Journal:  Eur J Clin Pharmacol       Date:  2013-06-14       Impact factor: 2.953

Review 10.  Rapid drug desensitization for hypersensitivity reactions to chemotherapy and monoclonal antibodies in the 21st century.

Authors:  M C Castells Guitart
Journal:  J Investig Allergol Clin Immunol       Date:  2014       Impact factor: 4.333
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  1 in total

1.  Pediatric drug hypersensitivity: which diagnostic tests?

Authors:  Francesca Saretta; Francesca Mori; Fabio Cardinale; Lucia Liotti; Fabrizio Franceschini; Giuseppe Crisafulli; Silvia Caimmi; Paolo Bottau; Roberto Bernardini; Carlo Caffarelli
Journal:  Acta Biomed       Date:  2019-01-30
  1 in total

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