Erin P Ward1, James Wang2, Natalie Mendez3, Jian Yang3, Chris Barback1, Jessica Wang-Rodriguez4, William Trogler3, Andrew C Kummel3, Sarah Blair5. 1. Moores Cancer Center, University of California, 3855 Heath Science Dr MC 0987, San Diego, CA 92093, USA. 2. Department of Nanoengineering, University of California, San Diego, CA, USA. 3. Department of Chemistry and Biochemistry, University of California, San Diego, CA, USA. 4. Department of Pathology, University of California, San Diego, CA, USA. 5. Moores Cancer Center, University of California, 3855 Heath Science Dr MC 0987, San Diego, CA 92093, USA. Electronic address: slblair@ucsd.edu.
Abstract
BACKGROUND: We aimed to evaluate the potential for ultrasound (US) visible biodegradable nanoshells (NS) as an alternative to wire-guided localization for nonpalpable tumors in vivo. METHODS: VX2 tumor was injected in bilateral thighs of 22 New Zealand rabbits and after 5 to 10 days, 1 tumor was marked with a wire as a control and the contralateral tumor was injected with 1 mL of 500 nm gas-filled silica NS under Doppler US. Tumors were excised after 24 hours. Chi-square was used for significance, P = .05. RESULTS: One rabbit was excluded on postoperative day 1 due to equipment failure, no ill effects were observed from the NS. The NS were used to localize and resect 100% of marked tissue, 4/21 wires were displaced (P < .05). CONCLUSIONS: We have shown that preoperatively injected US visible silica NS can be successfully used to mark nonpalpable tumors in vivo more consistently than WL. Copyright Â
BACKGROUND: We aimed to evaluate the potential for ultrasound (US) visible biodegradable nanoshells (NS) as an alternative to wire-guided localization for nonpalpable tumors in vivo. METHODS: VX2 tumor was injected in bilateral thighs of 22 New Zealand rabbits and after 5 to 10 days, 1 tumor was marked with a wire as a control and the contralateral tumor was injected with 1 mL of 500 nm gas-filled silica NS under Doppler US. Tumors were excised after 24 hours. Chi-square was used for significance, P = .05. RESULTS: One rabbit was excluded on postoperative day 1 due to equipment failure, no ill effects were observed from the NS. The NS were used to localize and resect 100% of marked tissue, 4/21 wires were displaced (P < .05). CONCLUSIONS: We have shown that preoperatively injected US visible silica NS can be successfully used to mark nonpalpable tumors in vivo more consistently than WL. Copyright Â
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