Alicia J Spittle1,2,3, Jennifer M Walsh2,3,4, Cody Potter2, Emma Mcinnes2,3, Joy E Olsen2,3,5, Katherine J Lee2,6, Peter J Anderson2,6, Lex W Doyle2,3,5,6, Jeanie L Y Cheong2,3,5. 1. Department of Physiotherapy, University of Melbourne, Melbourne, Vic, Australia. 2. Murdoch Childrens Research Institute, Melbourne, Vic, Australia. 3. Newborn Research, Royal Women's Hospital, Melbourne, Vic, Australia. 4. Paediatric Infant Perinatal Emergency Retrieval (PIPER), The Royal Children's Hospital, Melbourne, Vic, Australia. 5. Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Vic, Australia. 6. Department of Paediatrics, University of Melbourne, Melbourne, Vic, Australia.
Abstract
AIM: To examine the association between newborn neurobehavioural assessments and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm (MLPT). METHOD: Two-hundred and one infants born MLPT (born 32-36+6 wks' gestation) were assessed with the Hammersmith Neonatal Neurological Examination (HNNE) and NICU Network Neurobehavioral Scale (NNNS), with suboptimal performance defined as scores lower than the 10th centile. Development was assessed at 2 years corrected age with the Bayley Scales of Infant and Toddler Development 3rd Edition, with delay defined as scores less than 1 standard deviation (SD) below the mean. The relationships between neurobehaviour at term and Bayley-III cognitive, language, and motor scales at 2 years were examined using linear regression. RESULTS: Increased odds for cognitive delay were associated with suboptimal HNNE total scores (odds ratio [OR] 2.66; 95% confidence interval [CI] 1.14-6.23, p=0.020) and suboptimal NNNS excitability (OR 3.01; 95% CI 1.33-6.82, p=0.008) and lethargy (OR 4.05; 95% CI 1.75-9.31, p=0.001) scores. Suboptimal lethargy scores on the NNNS were associated with increased odds of language (OR 5.64; 95% CI 1.33-23.85, p=0.019) and motor delay (OR: 6.86; 95% CI 1.64-28.71, p=0.08). INTERPRETATION: Suboptimal performance on specific aspects of newborn neurobehavioural assessments is associated with neurodevelopmental delay at 2 years in children born MLPT.
AIM: To examine the association between newborn neurobehavioural assessments and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm (MLPT). METHOD: Two-hundred and one infantsborn MLPT (born 32-36+6 wks' gestation) were assessed with the Hammersmith Neonatal Neurological Examination (HNNE) and NICU Network Neurobehavioral Scale (NNNS), with suboptimal performance defined as scores lower than the 10th centile. Development was assessed at 2 years corrected age with the Bayley Scales of Infant and Toddler Development 3rd Edition, with delay defined as scores less than 1 standard deviation (SD) below the mean. The relationships between neurobehaviour at term and Bayley-III cognitive, language, and motor scales at 2 years were examined using linear regression. RESULTS: Increased odds for cognitive delay were associated with suboptimal HNNE total scores (odds ratio [OR] 2.66; 95% confidence interval [CI] 1.14-6.23, p=0.020) and suboptimal NNNS excitability (OR 3.01; 95% CI 1.33-6.82, p=0.008) and lethargy (OR 4.05; 95% CI 1.75-9.31, p=0.001) scores. Suboptimal lethargy scores on the NNNS were associated with increased odds of language (OR 5.64; 95% CI 1.33-23.85, p=0.019) and motor delay (OR: 6.86; 95% CI 1.64-28.71, p=0.08). INTERPRETATION: Suboptimal performance on specific aspects of newborn neurobehavioural assessments is associated with neurodevelopmental delay at 2 years in childrenborn MLPT.
Authors: Isabel U Huf; Emmah Baque; Paul B Colditz; Mark D Chatfield; Robert S Ware; Roslyn N Boyd; Joanne M George Journal: Pediatr Res Date: 2022-09-23 Impact factor: 3.953
Authors: Kelly W Sheppard; Kelly M Boone; Barbara Gracious; Mark A Klebanoff; Lynette K Rogers; Joseph Rausch; Christopher Bartlett; Daniel L Coury; Sarah A Keim Journal: J Autism Dev Disord Date: 2017-11