Literature DB >> 27771445

Spot-welding solid targets for high current cyclotron irradiation.

Paul A Ellison1, Hector F Valdovinos1, Stephen A Graves1, Todd E Barnhart1, Robert J Nickles2.   

Abstract

Zirconium-89 finds broad application for use in positron emission tomography. Its cyclotron production has been limited by the heat transfer from yttrium targets at high beam currents. A spot welding technique allows a three-fold increase in beam current, without affecting 89Zr quality. An yttrium foil, welded to a jet-cooled tantalum support base accommodates a 50µA proton beam degraded to 14MeV. The resulting activity yield of 48±4 MBq/(μA∙hr) now extends the outreach of 89Zr for a broader distribution.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  (89)Zr; Cyclotron solid targetry; Spot welding; Ti-44; Zirconium-89; Zr-89

Year:  2016        PMID: 27771445      PMCID: PMC5164840          DOI: 10.1016/j.apradiso.2016.10.010

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN: 0969-8043            Impact factor:   1.513


  6 in total

1.  Radiometal-labeled agents (non-technetium) for diagnostic imaging.

Authors:  C J Anderson; M J Welch
Journal:  Chem Rev       Date:  1999-09-08       Impact factor: 60.622

2.  An alumina ceramic target vessel for the remote production of metallic radionuclides by in situ target dissolution.

Authors:  Kotaro Nagatsu; Hisashi Suzuki; Masami Fukada; Katsuyuki Minegishi; Atsushi Tsuji; Toshimitsu Fukumura
Journal:  Nucl Med Biol       Date:  2012-06-23       Impact factor: 2.408

3.  Improved production and processing of ⁸⁹Zr using a solution target.

Authors:  Mukesh K Pandey; Aditya Bansal; Hendrik P Engelbrecht; John F Byrne; Alan B Packard; Timothy R DeGrado
Journal:  Nucl Med Biol       Date:  2015-09-21       Impact factor: 2.408

4.  A solid target system with remote handling of irradiated targets for PET cyclotrons.

Authors:  J Siikanen; T A Tran; T G Olsson; S-E Strand; A Sandell
Journal:  Appl Radiat Isot       Date:  2014-12       Impact factor: 1.513

5.  Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89.

Authors:  W E Meijs; J D Herscheid; H J Haisma; H M Pinedo
Journal:  Int J Rad Appl Instrum A       Date:  1992-12

6.  Standardized methods for the production of high specific-activity zirconium-89.

Authors:  Jason P Holland; Yiauchung Sheh; Jason S Lewis
Journal:  Nucl Med Biol       Date:  2009-07-29       Impact factor: 2.408

  6 in total
  6 in total

1.  Noninvasive Imaging and Quantification of Radiotherapy-Induced PD-L1 Upregulation with 89Zr-Df-Atezolizumab.

Authors:  Emily B Ehlerding; Hye Jin Lee; Todd E Barnhart; Dawei Jiang; Lei Kang; Douglas G McNeel; Jonathan W Engle; Weibo Cai
Journal:  Bioconjug Chem       Date:  2019-04-19       Impact factor: 4.774

2.  Evaluation of a chloride-based 89Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin.

Authors:  Stephen A Graves; Christopher Kutyreff; Kendall E Barrett; Reinier Hernandez; Paul A Ellison; Steffen Happel; Eduardo Aluicio-Sarduy; Todd E Barnhart; Robert J Nickles; Jonathan W Engle
Journal:  Nucl Med Biol       Date:  2018-06-18       Impact factor: 2.408

Review 3.  PET radiometals for antibody labeling.

Authors:  Eduardo Aluicio-Sarduy; Paul A Ellison; Todd E Barnhart; Weibo Cai; Robert Jerry Nickles; Jonathan W Engle
Journal:  J Labelled Comp Radiopharm       Date:  2018-03-12       Impact factor: 1.921

Review 4.  Production of novel diagnostic radionuclides in small medical cyclotrons.

Authors:  Mateusz Adam Synowiecki; Lars Rutger Perk; J Frank W Nijsen
Journal:  EJNMMI Radiopharm Chem       Date:  2018-02-20

Review 5.  Current Perspectives on 89Zr-PET Imaging.

Authors:  Joon-Kee Yoon; Bok-Nam Park; Eun-Kyoung Ryu; Young-Sil An; Su-Jin Lee
Journal:  Int J Mol Sci       Date:  2020-06-17       Impact factor: 5.923

6.  A High Separation Factor for 165Er from Ho for Targeted Radionuclide Therapy.

Authors:  Isidro Da Silva; Taylor R Johnson; Jason C Mixdorf; Eduardo Aluicio-Sarduy; Todd E Barnhart; R Jerome Nickles; Jonathan W Engle; Paul A Ellison
Journal:  Molecules       Date:  2021-12-11       Impact factor: 4.927

  6 in total

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