Annemiek Dols1, Filip Bouckaert2, Pascal Sienaert3, Didi Rhebergen4, Kristof Vansteelandt5, Mara Ten Kate6, Francois-Laurent de Winter7, Hannie C Comijs4, Louise Emsell8, Mardien L Oudega4, Eric van Exel4, Sigfried Schouws4, Jasmien Obbels3, Mike Wattjes6, Frederik Barkhof6, Piet Eikelenboom9, Mathieu Vandenbulcke7, Max L Stek4. 1. Department of Old Age Psychiatry, GGZ inGeest, VU University Medical Center, Amsterdam, The Netherlands; EMGO+ Institute of Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: a.dols@ggzingeest.nl. 2. Old-age Psychiatry, University Psychiatric Center KU Leuven, Leuven/Kortenberg, Belgium; Academic Center for ECT and Neuromodulation, University Psychiatric Center KU Leuven, Leuven/Kortenberg, Belgium. 3. Academic Center for ECT and Neuromodulation, University Psychiatric Center KU Leuven, Leuven/Kortenberg, Belgium. 4. Department of Old Age Psychiatry, GGZ inGeest, VU University Medical Center, Amsterdam, The Netherlands; EMGO+ Institute of Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. 5. Department of Psychiatry, University Psychiatric Center KU Leuven, Leuven/Kortenberg, Belgium; Research Group of Quantitative Psychology and Individual Differences, University Psychiatric Center KU Leuven, Leuven/Kortenberg, Belgium. 6. Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands. 7. Old-age Psychiatry, University Psychiatric Center KU Leuven, Leuven/Kortenberg, Belgium. 8. Old-age Psychiatry, University Psychiatric Center KU Leuven, Leuven/Kortenberg, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven & Radiology, University Hospitals Leuven, Leuven, Belgium. 9. Department of Old Age Psychiatry, GGZ inGeest, VU University Medical Center, Amsterdam, The Netherlands.
Abstract
OBJECTIVE: The clinical profile of late-life depression (LLD) is frequently associated with cognitive impairment, aging-related brain changes, and somatic comorbidity. This two-site naturalistic longitudinal study aimed to explore differences in clinical and brain characteristics and response to electroconvulsive therapy (ECT) in early- (EOD) versus late-onset (LOD) late-life depression (respectively onset <55 and ≥55 years). METHODS: Between January 2011 and December 2013, 110 patients aged 55 years and older with ECT-treated unipolar depression were included in The Mood Disorders in Elderly treated with ECT study. Clinical profile and somatic health were assessed. Magnetic resonance imaging (MRI) scans were performed before the first ECT and visually rated. RESULTS: Response rate was 78.2% and similar between the two sites but significantly higher in LOD compared with EOD (86.9 versus 67.3%). Clinical, somatic, and brain characteristics were not different between EOD and LOD. Response to ECT was associated with late age at onset and presence of psychotic symptoms and not with structural MRI characteristics. In EOD only, the odds for a higher response were associated with a shorter index episode. CONCLUSION: The clinical profile, somatic comorbidities, and brain characteristics in LLD were similar in EOD and LOD. Nevertheless, patients with LOD showed a superior response to ECT compared with patients with EOD. Our results indicate that ECT is very effective in LLD, even in vascular burdened patients.
OBJECTIVE: The clinical profile of late-life depression (LLD) is frequently associated with cognitive impairment, aging-related brain changes, and somatic comorbidity. This two-site naturalistic longitudinal study aimed to explore differences in clinical and brain characteristics and response to electroconvulsive therapy (ECT) in early- (EOD) versus late-onset (LOD) late-life depression (respectively onset <55 and ≥55 years). METHODS: Between January 2011 and December 2013, 110 patients aged 55 years and older with ECT-treated unipolar depression were included in The Mood Disorders in Elderly treated with ECT study. Clinical profile and somatic health were assessed. Magnetic resonance imaging (MRI) scans were performed before the first ECT and visually rated. RESULTS: Response rate was 78.2% and similar between the two sites but significantly higher in LOD compared with EOD (86.9 versus 67.3%). Clinical, somatic, and brain characteristics were not different between EOD and LOD. Response to ECT was associated with late age at onset and presence of psychotic symptoms and not with structural MRI characteristics. In EOD only, the odds for a higher response were associated with a shorter index episode. CONCLUSION: The clinical profile, somatic comorbidities, and brain characteristics in LLD were similar in EOD and LOD. Nevertheless, patients with LOD showed a superior response to ECT compared with patients with EOD. Our results indicate that ECT is very effective in LLD, even in vascular burdened patients.
Authors: Leif Oltedal; Hauke Bartsch; Ole Johan Evjenth Sørhaug; Ute Kessler; Christopher Abbott; Annemieke Dols; Max L Stek; Lars Ersland; Louise Emsell; Philip van Eijndhoven; Miklos Argyelan; Indira Tendolkar; Pia Nordanskog; Paul Hamilton; Martin Balslev Jorgensen; Iris E Sommer; Sophie M Heringa; Bogdan Draganski; Ronny Redlich; Udo Dannlowski; Harald Kugel; Filip Bouckaert; Pascal Sienaert; Amit Anand; Randall Espinoza; Katherine L Narr; Dominic Holland; Anders M Dale; Ketil J Oedegaard Journal: Neuroimage Clin Date: 2017-02-14 Impact factor: 4.881
Authors: Elisabeth Maria van Zutphen; Didi Rhebergen; Eric van Exel; Mardien Leoniek Oudega; Filip Bouckaert; Pascal Sienaert; Matthieu Vandenbulcke; Max Stek; Annemieke Dols Journal: Transl Psychiatry Date: 2019-05-24 Impact factor: 6.222
Authors: Mardien L Oudega; Ysbrand D van der Werf; Annemieke Dols; Mike P Wattjes; Frederik Barkhof; Filip Bouckaert; Mathieu Vandenbulcke; François-Laurent De Winter; Pascal Sienaert; Piet Eikelenboom; Max L Stek; Odile A van den Heuvel; Louise Emsell; Didi Rhebergen; Eric van Exel Journal: PLoS One Date: 2019-01-17 Impact factor: 3.240
Authors: M G A Van Cauwenberge; F Bouckaert; K Vansteelandt; C Adamson; F L De Winter; P Sienaert; J Van den Stock; A Dols; D Rhebergen; M L Stek; L Emsell; M Vandenbulcke Journal: Transl Psychiatry Date: 2021-04-01 Impact factor: 6.222
Authors: Dore Loef; Kristof Vansteelandt; Mardien L Oudega; Philip van Eijndhoven; Angela Carlier; Eric van Exel; Didi Rhebergen; Pascal Sienaert; Mathieu Vandenbulcke; Filip Bouckaert; Annemiek Dols Journal: Brain Behav Immun Health Date: 2021-11-16
Authors: Akihiro Takamiya; Annemiek Dols; Louise Emsell; Christopher Abbott; Antoine Yrondi; Carles Soriano Mas; Martin Balslev Jorgensen; Pia Nordanskog; Didi Rhebergen; Eric van Exel; Mardien L Oudega; Filip Bouckaert; Mathieu Vandenbulcke; Pascal Sienaert; Patrice Péran; Marta Cano; Narcis Cardoner; Anders Jorgensen; Olaf B Paulson; Paul Hamilton; Robin Kampe; Willem Bruin; Hauke Bartsch; Olga Therese Ousdal; Ute Kessler; Guido van Wingen; Leif Oltedal; Taishiro Kishimoto Journal: Schizophr Bull Date: 2022-03-01 Impact factor: 9.306