Literature DB >> 27768570

Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report.

Scott Shannon1, Janet Opila-Lehman2.   

Abstract

INTRODUCTION: Anxiety and sleep disorders are often the result of posttraumatic stress disorder and can contribute to an impaired ability to focus and to demonstration of oppositional behaviors. CASE
PRESENTATION: These symptoms were present in our patient, a ten-year-old girl who was sexually abused and had minimal parental supervision as a young child under the age of five. Pharmaceutical medications provided partial relief, but results were not long-lasting, and there were major side effects. A trial of cannabidiol oil resulted in a maintained decrease in anxiety and a steady improvement in the quality and quantity of the patient's sleep. DISCUSSION: Cannabidiol oil, an increasingly popular treatment of anxiety and sleep issues, has been documented as being an effective alternative to pharmaceutical medications. This case study provides clinical data that support the use of cannabidiol oil as a safe treatment for reducing anxiety and improving sleep in a young girl with posttraumatic stress disorder.

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Year:  2016        PMID: 27768570      PMCID: PMC5101100          DOI: 10.7812/TPP/16-005

Source DB:  PubMed          Journal:  Perm J        ISSN: 1552-5767


  13 in total

Review 1.  Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

Authors:  Javier Fernández-Ruiz; Onintza Sagredo; M Ruth Pazos; Concepción García; Roger Pertwee; Raphael Mechoulam; José Martínez-Orgado
Journal:  Br J Clin Pharmacol       Date:  2013-02       Impact factor: 4.335

2.  Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats.

Authors:  Yi-Tse Hsiao; Pei-Lu Yi; Chia-Ling Li; Fang-Chia Chang
Journal:  Neuropharmacology       Date:  2011-08-16       Impact factor: 5.250

Review 3.  Safety and side effects of cannabidiol, a Cannabis sativa constituent.

Authors:  Mateus Machado Bergamaschi; Regina Helena Costa Queiroz; Antonio Waldo Zuardi; José Alexandre S Crippa
Journal:  Curr Drug Saf       Date:  2011-09-01

Review 4.  Cannabidiol (CBD) and its analogs: a review of their effects on inflammation.

Authors:  Sumner Burstein
Journal:  Bioorg Med Chem       Date:  2015-02-07       Impact factor: 3.641

5.  Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.

Authors:  José Alexandre S Crippa; Guilherme Nogueira Derenusson; Thiago Borduqui Ferrari; Lauro Wichert-Ana; Fábio L S Duran; Rocio Martin-Santos; Marcus Vinícius Simões; Sagnik Bhattacharyya; Paolo Fusar-Poli; Zerrin Atakan; Alaor Santos Filho; Maria Cecília Freitas-Ferrari; Philip K McGuire; Antonio Waldo Zuardi; Geraldo F Busatto; Jaime Eduardo Cecílio Hallak
Journal:  J Psychopharmacol       Date:  2010-09-09       Impact factor: 4.153

Review 6.  Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug.

Authors:  A W Zuardi; J A S Crippa; J E C Hallak; F A Moreira; F S Guimarães
Journal:  Braz J Med Biol Res       Date:  2006-04-03       Impact factor: 2.590

7.  Sleep disturbance scale for children: translation, cultural adaptation, and validation.

Authors:  Vanessa Ruotolo Ferreira; Luciane B C Carvalho; Fabiana Ruotolo; José Fausto de Morais; Lucila B F Prado; Gilmar F Prado
Journal:  Sleep Med       Date:  2008-08-15       Impact factor: 3.492

8.  Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory.

Authors:  Edward F Pace-Schott; Anne Germain; Mohammed R Milad
Journal:  Biol Mood Anxiety Disord       Date:  2015-05-29

9.  Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia.

Authors:  F M Leweke; D Piomelli; F Pahlisch; D Muhl; C W Gerth; C Hoyer; J Klosterkötter; M Hellmich; D Koethe
Journal:  Transl Psychiatry       Date:  2012-03-20       Impact factor: 6.222

10.  Cannabidiol in humans-the quest for therapeutic targets.

Authors:  Simon Zhornitsky; Stéphane Potvin
Journal:  Pharmaceuticals (Basel)       Date:  2012-05-21
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  28 in total

Review 1.  Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders.

Authors:  Jonathan L C Lee; Leandro J Bertoglio; Francisco S Guimarães; Carl W Stevenson
Journal:  Br J Pharmacol       Date:  2017-03-09       Impact factor: 8.739

Review 2.  Cannabis, Cannabinoids, and Sleep: a Review of the Literature.

Authors:  Kimberly A Babson; James Sottile; Danielle Morabito
Journal:  Curr Psychiatry Rep       Date:  2017-04       Impact factor: 5.285

3.  Changes in Cortisol Awakening Response Before and After Development of Posttraumatic Stress Disorder, Which Cannot be Avoided with Use of Cannabidiol: A Case Report.

Authors:  Lívia Maria Bolsoni; Thiago Dornela Apolinário da Silva; Silvana Maria Quintana; Margaret de Castro; José Alexandre Crippa; Antonio Waldo Zuardi
Journal:  Perm J       Date:  2019-09-27

Review 4.  Use of Cannabidiol for the Treatment of Anxiety: A Short Synthesis of Pre-Clinical and Clinical Evidence.

Authors:  Madison Wright; Patricia Di Ciano; Bruna Brands
Journal:  Cannabis Cannabinoid Res       Date:  2020-09-02

5.  Therapeutic Efficacy of Cannabidiol (CBD): A Review of the Evidence from Clinical Trials and Human Laboratory Studies.

Authors:  Dennis J Sholler; Lauren Schoene; Tory R Spindle
Journal:  Curr Addict Rep       Date:  2020-07-25

6.  No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.

Authors:  Ila M P Linares; Francisco S Guimaraes; Alan Eckeli; Ana C S Crippa; Antonio W Zuardi; Jose D S Souza; Jaime E Hallak; José A S Crippa
Journal:  Front Pharmacol       Date:  2018-04-05       Impact factor: 5.810

7.  Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) for chronic insomnia disorder ('CANSLEEP' trial): protocol for a randomised, placebo-controlled, double-blinded, proof-of-concept trial.

Authors:  Anastasia Suraev; Ronald R Grunstein; Nathaniel S Marshall; Angela L D'Rozario; Christopher J Gordon; Delwyn J Bartlett; Keith Wong; Brendon J Yee; Ryan Vandrey; Chris Irwin; Jonathon C Arnold; Iain S McGregor; Camilla M Hoyos
Journal:  BMJ Open       Date:  2020-05-18       Impact factor: 2.692

8.  The Endocannabinoid System May Modulate Sleep Disorders in Aging.

Authors:  Eric Murillo-Rodríguez; Henning Budde; André Barciela Veras; Nuno Barbosa Rocha; Diogo Telles-Correia; Diogo Monteiro; Luis Cid; Tetsuya Yamamoto; Sérgio Machado; Pablo Torterolo
Journal:  Curr Neuropharmacol       Date:  2020       Impact factor: 7.363

Review 9.  Could Cannabidiol Be a Treatment for Coronavirus Disease-19-Related Anxiety Disorders?

Authors:  Saoirse E O'Sullivan; Carl W Stevenson; Steven R Laviolette
Journal:  Cannabis Cannabinoid Res       Date:  2021-02-12

10.  Treatment of social anxiety disorder and attenuated psychotic symptoms with cannabidiol.

Authors:  Maximus Berger; Emily Li; Günter Paul Amminger
Journal:  BMJ Case Rep       Date:  2020-10-07
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