Lívia Maria Bolsoni1, Thiago Dornela Apolinário da Silva2, Silvana Maria Quintana2, Margaret de Castro3, José Alexandre Crippa1,4, Antonio Waldo Zuardi1,4. 1. Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo, Brazil. 2. Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, University of São Paulo, Brazil. 3. Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Brazil. 4. National Institute of Science and Technology for Translational Medicine, National Council for Scientific and Technological Development, Brasília, Brazil.
Abstract
INTRODUCTION: Previous studies have shown attenuated cortisol awakening response in patients with posttraumatic stress disorder (PTSD). CASE PRESENTATION: A 15-year-old girl, a survivor of acute sexual violence, received a 7-day oral treatment with cannabidiol. She was followed-up from the first 24 hours after the event for 6 months, for assessment of the effects of this treatment on the reconsolidation of memories related to the traumatic event. DISCUSSION: Cannabidiol treatment did not prevent the onset of PTSD. Cortisol awakening responses after the onset of the disorder were attenuated compared with those observed in the same individual before the onset of PTSD, in line with previous evidence from studies comparing groups with and without PTSD.
INTRODUCTION: Previous studies have shown attenuated cortisol awakening response in patients with posttraumatic stress disorder (PTSD). CASE PRESENTATION: A 15-year-old girl, a survivor of acute sexual violence, received a 7-day oral treatment with cannabidiol. She was followed-up from the first 24 hours after the event for 6 months, for assessment of the effects of this treatment on the reconsolidation of memories related to the traumatic event. DISCUSSION: Cannabidiol treatment did not prevent the onset of PTSD. Cortisol awakening responses after the onset of the disorder were attenuated compared with those observed in the same individual before the onset of PTSD, in line with previous evidence from studies comparing groups with and without PTSD.
Authors: Cristina A J Stern; Lucas Gazarini; Ana C Vanvossen; Antonio W Zuardi; Ismael Galve-Roperh; Francisco S Guimaraes; Reinaldo N Takahashi; Leandro J Bertoglio Journal: Eur Neuropsychopharmacol Date: 2015-02-16 Impact factor: 4.600
Authors: Cristina A J Stern; Lucas Gazarini; Reinaldo N Takahashi; Francisco S Guimarães; Leandro J Bertoglio Journal: Neuropsychopharmacology Date: 2012-05-02 Impact factor: 7.853
Authors: C S de Kloet; E Vermetten; C J Heijnen; E Geuze; E G W M Lentjes; H G M Westenberg Journal: Psychoneuroendocrinology Date: 2007-02-12 Impact factor: 4.905
Authors: Lívia Maria Bolsoni; José Alexandre S Crippa; Jaime Eduardo Cecílio Hallak; Francisco Silveira Guimarães; Antonio Waldo Zuardi Journal: Braz J Psychiatry Date: 2022 May-Jun