| Literature DB >> 27765684 |
Tatiane Aparecida Ribeiro1, Kelly Valério Prates2, Audrei Pavanello2, Ananda Malta2, Laize Peron Tófolo2, Isabela Peixoto Martins2, Júlio Cezar de Oliveira3, Rosiane Aparecida Miranda4, Rodrigo Mello Gomes5, Elaine Vieira2, Claudinéia Conationi da Silva Franco2, Luiz Felipe Barella6, Flávio Andrade Francisco2, Vander Silva Alves2, Sandra da Silva Silveira2, Veridiana Mota Moreira2, Gabriel Sergio Fabricio7, Kesia Palma-Rigo2, Deborah M Sloboda8, Paulo Cezar de Freitas Mathias9.
Abstract
Acephate has been used extensively as an insecticide in agriculture. Its downstream sequelae are associated with hyperglycemia, lipid metabolism dysfunction, DNA damage, and cancer, which are rapidly growing epidemics and which lead to increased morbidity and mortality rates and soaring health-care costs. Developing interventions will require a comprehensive understanding of which excess insecticides during perinatal life can cause insulin resistance and type 2 diabetes. A Wistar rat animal model suggests that acephate exposure during pregnancy and lactation causes alterations in maternal glucose metabolism and programs the offspring to be susceptible to type 2 diabetes at adulthood. Therapeutic approaches based on preventive actions to food contaminated with insecticides during pregnancy and lactation could prevent new cases of type 2 diabetes. Copyright ÂEntities:
Keywords: Acephate; Glucose metabolism; Lactation; Lipid metabolism; Offspring; Pregnancy
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Year: 2016 PMID： 27765684 DOI： 10.1016/j.tox.2016.10.010
Source DB: PubMed Journal: Toxicology ISSN： 0300-483X Impact factor: 4.221