Literature DB >> 27764663

Re-energizing the Development of Pain Therapeutics in Light of the Opioid Epidemic.

Phil Skolnick1, Nora D Volkow2.   

Abstract

Limited options for treating moderate-severe pain led to an overreliance on opioids and the current opioid epidemic. Addressing the factors contributing to a dearth of effective alternatives and re-energizing the development of pain therapeutics is necessary to quell this epidemic. Published by Elsevier Inc.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 27764663     DOI： 10.1016/j.neuron.2016.09.051

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  27 in total

1.  Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain.

Authors:  Val J Watts
Journal:  Neuropsychopharmacology       Date:  2018-01       Impact factor: 7.853

Review 2.  Regulators of G Protein Signaling in Analgesia and Addiction.

Authors:  Farhana Sakloth; Claire Polizu; Feodora Bertherat; Venetia Zachariou
Journal:  Mol Pharmacol       Date:  2020-05-30       Impact factor: 4.436

Review 3.  Placebo Analgesia in Rodents: Current and Future Research.

Authors:  Asaf Keller; Titilola Akintola; Luana Colloca
Journal:  Int Rev Neurobiol       Date:  2018-03-07       Impact factor: 3.230

4.  Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway.

Authors:  Sevasti Gaspari; Immanuel Purushothaman; Valeria Cogliani; Farhana Sakloth; Rachael L Neve; David Howland; Robert H Ring; Elliott M Ross; Li Shen; Venetia Zachariou
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-12       Impact factor: 11.205

5.  Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming in mice.

Authors:  Michael D Burton; Dipti V Tillu; Khadijah Mazhar; Galo L Mejia; Marina N Asiedu; Kufreobong Inyang; Travis Hughes; Bo Lian; Gregory Dussor; Theodore J Price
Journal:  Neuroscience       Date:  2017-07-17       Impact factor: 3.590

6.  Preference for an Opioid/Benzodiazepine Mixture over an Opioid Alone Using a Concurrent Choice Procedure in Rhesus Monkeys.

Authors:  Peter F Weed; Charles P France; Lisa R Gerak
Journal:  J Pharmacol Exp Ther       Date:  2017-04-24       Impact factor: 4.030

7.  Transition to chronic pain: opportunities for novel therapeutics.

Authors:  Theodore J Price; Allan I Basbaum; Jacqueline Bresnahan; Jan F Chambers; Yves De Koninck; Robert R Edwards; Ru-Rong Ji; Joel Katz; Annemieke Kavelaars; Jon D Levine; Linda Porter; Neil Schechter; Kathleen A Sluka; Gregory W Terman; Tor D Wager; Tony L Yaksh; Robert H Dworkin
Journal:  Nat Rev Neurosci       Date:  2018-07       Impact factor: 34.870

Review 8.  From Mechanism to Cure: Renewing the Goal to Eliminate the Disease of Pain.

Authors:  Theodore J Price; Michael S Gold
Journal:  Pain Med       Date:  2018-08-01       Impact factor: 3.750

9.  Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents.

Authors:  Caroline M Kopruszinski; Juliana Swiokla; Yeon Sun Lee; Edita Navratilova; Laurie VanderVeen; Miao Yang; Yi Liu; Takahiro Miyazaki; William K Schmidt; Jonathan Zalevsky; Frank Porreca
Journal:  Cell Mol Neurobiol       Date:  2020-02-27       Impact factor: 5.046

10.  Lumbar lordosis as tool to assess the level of pain in patients with low back pain after lumbar disc herniation.

Authors:  Markus Rafael Konieczny; Sina Schroer; Christoph Schleich; Max Prost; Martin Hufeland; Hannes Kubo; Rüdiger Krauspe
Journal:  J Orthop       Date:  2020-05-01
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.