Daniel A De Luis1, Rocío Aller, Olatz Izaola, David Primo, E Romero. 1. Centro de Investigación de Endocrinología y Nutrición. Medicine School. Universidad de Valladolid. Valladolid, Spain. Department of Endocrinology and Nutrition. Hospital Clínico Universitario de Valladolid. Valladolid. dadluis@yahoo.es.
Abstract
INTRODUCTION: The aim of our study was to analyze the relationship of the rs9939609 FTO gene polymorphism with insulin resistance and serum adipokine levels. MATERIAL AND METHODS: A population of 610 patients with obesity was analyzed in a cross sectional design. Weight, blood pressure, basal glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), lipid profile and adipocytokines (leptin, adiponectin, resistin, TNF alpha, and interleukin 6) levels were measured. RESULTS: Insulin (122.2 ± 101.8 pmol/L vs. 104.5 ± 61.5 pmol/L vs.112.1 ± 74.3 pmol/L:p < 0.05) and HOMA-IR values (4.76 ± 4.4 vs. 3.71 ± 2.5 vs.3.76 ± 3.1;p < 0.05) were higher in TT group than AT and AA groups. Triglycerides values were higher in TT group than AA group (1.42 ± 0.71 mmol/L vs.1.39 ± 0.69 mmol/L vs.1.23 ± 0.64 mmol/L;p < 0.05). Adiponectin levels were lower in TT genotype group than AA genotype group (35801.2 ± 35,912.3 ng/L vs.26,718.1 ± 36,323.1 ng/L vs. 21,112.3 ± 25,623.1 ng/L p < 0.05). CONCLUSION: The FTO gene polymorphism, rs9939609, was found to be associated with insulin resistance, insulin, triglyceride and adiponectin levels in obese patients with TT variant.
INTRODUCTION: The aim of our study was to analyze the relationship of the rs9939609FTO gene polymorphism with insulin resistance and serum adipokine levels. MATERIAL AND METHODS: A population of 610 patients with obesity was analyzed in a cross sectional design. Weight, blood pressure, basal glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), lipid profile and adipocytokines (leptin, adiponectin, resistin, TNF alpha, and interleukin 6) levels were measured. RESULTS:Insulin (122.2 ± 101.8 pmol/L vs. 104.5 ± 61.5 pmol/L vs.112.1 ± 74.3 pmol/L:p < 0.05) and HOMA-IR values (4.76 ± 4.4 vs. 3.71 ± 2.5 vs.3.76 ± 3.1;p < 0.05) were higher in TT group than AT and AA groups. Triglycerides values were higher in TT group than AA group (1.42 ± 0.71 mmol/L vs.1.39 ± 0.69 mmol/L vs.1.23 ± 0.64 mmol/L;p < 0.05). Adiponectin levels were lower in TT genotype group than AA genotype group (35801.2 ± 35,912.3 ng/L vs.26,718.1 ± 36,323.1 ng/L vs. 21,112.3 ± 25,623.1 ng/L p < 0.05). CONCLUSION: The FTO gene polymorphism, rs9939609, was found to be associated with insulin resistance, insulin, triglyceride and adiponectin levels in obesepatients with TT variant.
Authors: Aleksey G Nikitin; Viktor Y Potapov; Olga I Brovkina; Ekaterina O Koksharova; Dmitry S Khodyrev; Yury I Philippov; Marina S Michurova; Minara S Shamkhalova; Olga K Vikulova; Svetlana A Smetanina; Lyudmila A Suplotova; Irina V Kononenko; Viktor Y Kalashnikov; Olga M Smirnova; Alexander Y Mayorov; Valery V Nosikov; Alexander V Averyanov; Marina V Shestakova Journal: PeerJ Date: 2017-07-13 Impact factor: 2.984
Authors: Jeannette L Salgado-Montilla; Jorge L Rodríguez-Cabán; Jonathan Sánchez-García; Ricardo Sánchez-Ortiz; Margarita Irizarry-Ramírez Journal: Arch Cancer Res Date: 2017-08-22