Literature DB >> 27758835

Relationship between childhood adversity and bipolar affective disorder: systematic review and meta-analysis.

J E Palmier-Claus1, K Berry2, S Bucci2, W Mansell2, F Varese2.   

Abstract

BACKGROUND: The relationship between childhood adversity and bipolar affective disorder remains unclear. AIMS: To understand the size and significance of this effect through a statistical synthesis of reported research.
METHOD: Search terms relating to childhood adversity and bipolar disorder were entered into Medline, EMBASE, PsycINFO and Web of Science. Eligible studies included a sample diagnosed with bipolar disorder, a comparison sample and a quantitative measure of childhood adversity.
RESULTS: In 19 eligible studies childhood adversity was 2.63 times (95% CI 2.00-3.47) more likely to have occurred in bipolar disorder compared with non-clinical controls. The effect of emotional abuse was particularly robust (OR = 4.04, 95% CI 3.12-5.22), but rates of adversity were similar to those in psychiatric controls.
CONCLUSIONS: Childhood adversity is associated with bipolar disorder, which has implications for the treatment of this clinical group. Further prospective research could clarify temporal causality and explanatory mechanisms. © The Royal College of Psychiatrists 2016.

Entities:  

Mesh：

Year:  2016        PMID： 27758835     DOI： 10.1192/bjp.bp.115.179655

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN： 0007-1250            Impact factor:   9.319


  31 in total

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5.  The Effect of Traumatic Events on the Longitudinal Course and Outcomes of Youth with Bipolar Disorder.

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Journal:  J Affect Disord       Date:  2020-12-24       Impact factor: 4.839

10.  Environmental Risk Factors in Bipolar Disorder and Psychotic Depression: A Systematic Review and Meta-Analysis of Prospective Studies.

Authors:  Victoria Rodriguez; Luis Alameda; Giulia Trotta; Edoardo Spinazzola; Paolo Marino; Sandra L Matheson; Kristin R Laurens; Robin M Murray; Evangelos Vassos
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