| Literature DB >> 27751627 |
Boopathy Ramakrishnan1, Karthik Viswanathan1, Kannan Tharakaraman2, Vlado Dančík3, Rahul Raman2, Gregory J Babcock1, Zachary Shriver1, Ram Sasisekharan4.
Abstract
Broadly neutralizing monoclonal antibodies (bNAbs) for viral infections, such as HIV, respiratory syncytial virus (RSV), and influenza, are increasingly entering clinical development. For influenza, most neutralizing antibodies target influenza virus hemagglutinin. These bNAbs represent an emerging, promising modality for treatment and prophylaxis of influenza due to their multiple mechanisms of antiviral action and generally safe profile. Preclinical work in other viral diseases, such as dengue, has demonstrated the potential for antibody-based therapies to enhance viral uptake, leading to enhanced viremia and worsening of disease. This phenomenon is referred to as antibody-dependent enhancement (ADE). In the context of influenza, ADE has been used to explain several preclinical and clinical phenomena. Using structural and viral kinetics modeling, we assess the role of ADE in the treatment of influenza with a bNAb.Entities:
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Year: 2016 PMID： 27751627 PMCID： PMC5526082 DOI： 10.1016/j.tim.2016.09.003
Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079