| Literature DB >> 27749836 |
K M Naga Srinivas Nadella1, Hana Roš1, Chiara Baragli1, Victoria A Griffiths1, George Konstantinou1, Theo Koimtzis1, Geoffrey J Evans1, Paul A Kirkby1, R Angus Silver1.
Abstract
Understanding how neural circuits process information requires rapid measurements of activity from identified neurons distributed in 3D space. Here we describe an acousto-optic lens two-photon microscope that performs high-speed focusing and line scanning within a volume spanning hundreds of micrometers. We demonstrate its random-access functionality by selectively imaging cerebellar interneurons sparsely distributed in 3D space and by simultaneously recording from the soma, proximal and distal dendrites of neocortical pyramidal cells in awake behaving mice.Entities:
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Year: 2016 PMID： 27749836 PMCID： PMC5769813 DOI： 10.1038/nmeth.4033
Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547