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Literature DB >> 27748713

Cellular and Molecular Imaging Using Chemical Exchange Saturation Transfer.

Abstract

Chemical exchange saturation transfer (CEST) is a powerful new tool well suited for molecular imaging. This technology enables the detection of low concentration probes through selective labeling of rapidly exchanging protons or other spins on the probes. In this review, we will highlight the unique features of CEST imaging technology and describe the different types of CEST agents that are suited for molecular imaging studies, including CEST theranostic agents, CEST reporter genes, and CEST environmental sensors.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Contrast Media

Year: 2016 PMID： 27748713 PMCID： PMC5082432 DOI： 10.1097/RMR.0000000000000105

Source DB: PubMed Journal: Top Magn Reson Imaging ISSN： 0899-3459

104 in total

Review 1. Nuclear magnetic resonance of laser-polarized noble gases in molecules, materials, and organisms.

Authors: Boyd M Goodson
Journal: J Magn Reson Date: 2002-04 Impact factor: 2.229

2. Targeted PARACEST nanoparticle contrast agent for the detection of fibrin.

Authors: Patrick M Winter; Kejia Cai; Junjie Chen; Christopher R Adair; Garry E Kiefer; Phillip S Athey; Patrick J Gaffney; Carolyn E Buff; J David Robertson; Shelton D Caruthers; Samuel A Wickline; Gregory M Lanza
Journal: Magn Reson Med Date: 2006-12 Impact factor: 4.668

3. Magnetic resonance imaging of dissolved hyperpolarized 129Xe using a membrane-based continuous flow system.

Authors: N Amor; P P Zänker; P Blümler; F M Meise; L M Schreiber; A Scholz; J Schmiedeskamp; H W Spiess; K Münnemann
Journal: J Magn Reson Date: 2009-08-14 Impact factor: 2.229

4. Analysis of fMRI data by blind separation into independent spatial components.

Authors: M J McKeown; S Makeig; G G Brown; T P Jung; S S Kindermann; A J Bell; T J Sejnowski
Journal: Hum Brain Mapp Date: 1998 Impact factor: 5.038

5. XeNA: an automated 'open-source' (129)Xe hyperpolarizer for clinical use.

Authors: Panayiotis Nikolaou; Aaron M Coffey; Laura L Walkup; Brogan M Gust; Nicholas Whiting; Hayley Newton; Iga Muradyan; Mikayel Dabaghyan; Kaili Ranta; Gregory D Moroz; Matthew S Rosen; Samuel Patz; Michael J Barlow; Eduard Y Chekmenev; Boyd M Goodson
Journal: Magn Reson Imaging Date: 2014-02-10 Impact factor: 2.546

6. Establishing the Lysine-rich Protein CEST Reporter Gene as a CEST MR Imaging Detector for Oncolytic Virotherapy.

Authors: Christian T Farrar; Jason S Buhrman; Guanshu Liu; Anne Kleijn; Martine L M Lamfers; Michael T McMahon; Assaf A Gilad; Giulia Fulci
Journal: Radiology Date: 2015-02-13 Impact factor: 11.105

7. Synthesis and characterisation of bismacrocyclic DO3A-amide derivatives - an approach towards metal-responsive PARACEST agents.

Authors: Nevenka Cakić; Tatjana Ž Verbić; Ratomir M Jelić; Carlos Platas-Iglesias; Goran Angelovski
Journal: Dalton Trans Date: 2016-04-21 Impact factor: 4.390

8. Magnetic resonance imaging investigation of macrophages in acute cardiac allograft rejection after heart transplantation.

Authors: Yijen L Wu; Qing Ye; Danielle F Eytan; Li Liu; Bedda L Rosario; T Kevin Hitchens; Fang-Cheng Yeh; Nico Rooijen van; Chien Ho
Journal: Circ Cardiovasc Imaging Date: 2013-10-04 Impact factor: 7.792

Cellular and Molecular Imaging Using Chemical Exchange Saturation Transfer.

Review 1. Nuclear magnetic resonance of laser-polarized noble gases in molecules, materials, and organisms.

2. Targeted PARACEST nanoparticle contrast agent for the detection of fibrin.

3. Magnetic resonance imaging of dissolved hyperpolarized 129Xe using a membrane-based continuous flow system.

4. Analysis of fMRI data by blind separation into independent spatial components.

5. XeNA: an automated 'open-source' (129)Xe hyperpolarizer for clinical use.

6. Establishing the Lysine-rich Protein CEST Reporter Gene as a CEST MR Imaging Detector for Oncolytic Virotherapy.

7. Synthesis and characterisation of bismacrocyclic DO3A-amide derivatives - an approach towards metal-responsive PARACEST agents.

8. Magnetic resonance imaging investigation of macrophages in acute cardiac allograft rejection after heart transplantation.

9. Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI.

10. Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer.

Review 1. Molecular fMRI of neurochemical signaling.

2. Nanomolar small-molecule detection using a genetically encoded ¹²⁹Xe NMR contrast agent.

3. Chemical exchange saturation transfer for detection of antiretroviral drugs in brain tissue.