Network Meta-Analysis and Cost Per Responder of Tumor Necrosis Factor-α and Interleukin Inhibitors in the Treatment of Active Ankylosing Spondylitis.

INTRODUCTION: Biologic therapies have improved the clinical management of ankylosing spondylitis (AS). Few head-to-head studies have directly compared the efficacy of these agents. This study was conducted to indirectly compare the efficacy of biologic agents for treatment of active AS.
METHODS: A targeted literature review was conducted to identify randomized clinical trials for adalimumab, infliximab, golimumab, certolizumab pegol, etanercept, and secukinumab for the treatment of active AS. The clinical efficacy was evaluated using ASAS20 and ASAS40 and synthesized via a Bayesian network meta-analysis. Number needed to treat (NNT) was calculated as the reciprocal of incremental response rate of each biologic versus placebo. Comparisons were also made in terms of cost per incremental ASAS20 or ASAS40 responder.
RESULTS: Fifteen studies were identified, which included ASAS20 and/or ASAS40 response rates at Week 12 to Week 16. Patients with AS treated with infliximab had the lowest NNT for ASAS20 of 2.3, followed by those treated with adalimumab (2.8) and etanercept (2.9). Adalimumab had the lowest 12-week cost per additional ASAS20 responder at $26,888, followed by infliximab at $28,175 and golimumab at $28,199. Patients treated with infliximab also had the lowest NNT for ASAS40 (2.6), followed by those treated with adalimumab (2.8) and secukinumab (3.5). Adalimumab had the lowest cost per additional ASAS40 responder at $26,898, followed by infliximab at $32,508 and etanercept at $34,406.
CONCLUSION: Infliximab had the lowest NNT to achieve an additional ASAS20/40 response, and adalimumab had the lowest cost per ASAS20/40 responder among biologic agents for the treatment of active AS. FUNDING: AbbVie.

Introduction

Ankylosing spondylitis (AS), a type of spondyloarthritis, is a chronic systemic rheumatic inflammatory disease of the axial skeleton, large peripheral joints, and entheses [1]. The principal feature of AS is inflammation of the sacroiliac joint at the base of the spine followed by rising inflammation along the spine, resulting in back pain and stiffness [2]. The standard of care for AS includes drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs), and non-drug interventions such as physical therapy. Although these drugs may offer palliation of symptoms, including spinal pain, peripheral joint pain, and physical function [1, 3], none has been shown to alter the progression of AS.

AS is associated with significant direct medical costs in terms of medication, outpatient visits, hospitalizations, and alternative treatments [4]. In addition, given the progressive nature of AS and the related loss of functional ability, it leads to an increase in work disability and loss of productivity, particularly for individuals who undertake manual work [5]. Hence, AS is associated with a significant economic burden on both patients and society [3, 6]. Effective treatment interventions can reduce the severity of the disease and increase patients’ physical function and overall quality of life, while also improving work capacity and productivity [7].

Targeted biologic therapies have revolutionized the clinical management of AS. Currently, five different tumor necrosis factor (TNF)-α inhibitors including adalimumab, certolizumab pegol, etanercept, golimumab, and infliximab are approved for the treatment of active AS (an infliximab biosimilar has also been approved, but is not currently marketed in the US). Secukinumab, an interleukin-17 inhibitor, was recently approved by the Food and Drug Administration (FDA) for the treatment of active AS [8]. Clinical trials have shown that these agents produce clinically important benefits to patients by improving physical functioning and reducing disease activity [9-13]. A previous meta-analysis synthesized data of different agents and concluded that TNF-α blockers improve disease activity and functional capacity for AS [14]. However, few head-to-head studies have directly compared the efficacy of these agents, and the comparative effectiveness among different biologic agents for AS treatment, especially for newer agents such as certolizumab pegol and secukinumab, is not well understood. Reliable evidence about the comparative effectiveness of these therapies is important to inform clinical and economic decisions regarding their use.

To fill these gaps, indirect comparisons of treatment outcomes across separate randomized trials can be used to provide valuable comparative evidence. Network meta-analysis is an approach that synthesizes information from several randomized comparisons to deliver internally consistent estimates of the treatment effects among competing interventions, while maintaining the randomization within each trial [15, 16]. Detailed methodological reviews and implementation guidelines for network meta-analyses have been published [15, 17–19], and network meta-analyses have become a preferred source of comparative evidence for researchers, health-care decision makers, and health technology assessment agencies [15, 20, 21].

The objective of this study was to determine the relative efficacy of the six approved biologic agents for active AS using a network meta-analysis, and to evaluate the incremental cost per responder for these agents over a 12-week treatment period.

Methods

Trial Identification

Phase III randomized clinical trials of TNF-α inhibitors (i.e., adalimumab, certolizumab pegol, etanercept, golimumab, and infliximab) and interleukin-17 inhibitors (i.e., secukinumab) for active AS were identified from a targeted literature review (January 1, 2000 to July 20, 2015). Trials were required to have been conducted among adult patients with active AS (defined as fulfilling the modified New York criteria for AS) [22]. Patients with non-radiographic axial spondylitis were excluded from this study. In addition, trials were required to be either placebo-controlled or a head-to-head comparison of two of the approved biologic agents. Trials were also required to have reported assessments in ankylosing spondylitis 20% response (ASAS20) and/or 40% response (ASAS40) at Week 12–16. Trial arms were required to use dose(s) approved by the FDA (e.g., adalimumab 40 mg every other week, golimumab 50 mg every month, and infliximab 5 mg/kg at 0, 2 and 6 weeks, then every 6 weeks). For certolizumab pegol and etanercept, which have two approved dosing schedules (certolizumab pegol 400 mg at week 0, 2, and 4 followed by either 200 mg every other week or 400 mg every 4 weeks, and etanercept 25 mg twice weekly or etanercept 50 mg once weekly, respectively), these dosing schedules were assumed to be equivalent therapeutic doses and analyzed jointly in the analysis. For secukinumab, two approved dosing schedules were included in this study—one with a loading dosage (150 mg at Weeks 0, 1, 2, 3, 4, and every 4 weeks thereafter) and one without a loading dosage (150 mg every 4 weeks). Secukinumab efficacy was evaluated collectively using the schedule with the loading dosage (the schedule with the loading dosage was examined during the double-blind placebo-controlled period in clinical trials, while the schedule without a loading dosage was evaluated among cross-over placebo patients), and costs were evaluated separately for the two secukinumab dosing schedules.

The study selection process was performed by two independent researchers with disagreements resolved by a third researcher. Data abstraction was performed by two independent researchers using a standardized data abstraction form.

Efficacy Measures

The ASAS criteria, the primary outcome in most AS trials, was used to define response [23]. ASAS20 is defined as an improvement of 20% (and absolute improvement of 10 units) in three of the four domains (patient global assessment, pain, function, and inflammation), and absence of deterioration in the potential remaining domain. ASAS40 is defined similarly with a required improvement of 40%. The Committee for Medicinal Products for Human use (CHMP) has noted that the higher improvement of ASAS40 may be a more appropriate endpoint to evaluate biologic therapies [24], and ASAS40 may be associated with clinical meaningful improvements in health-related quality of life [25]. For the purpose of analysis, outcomes were evaluated at week 12 (when week 12 outcomes were not available, outcomes reported at week 14 or week 16 were substituted for the week 12 outcomes).

Costs

This study was conducted from a US payer perspective, and only biologic drug acquisition costs and associated administration costs were considered in the analysis. Unit drug costs as of July 20, 2015 were based on the US wholesale acquisition cost (WAC) obtained from ReadyPrice® [26]. Based on the dosing schedules, unit costs, and administration costs, 12-week costs for each agent were calculated. The drug cost of infliximab was based on an 80-kg adult. Administration cost (intravenous infusion) for infliximab in the US as of July 20, 2015 was obtained from US Department of Health and Human Services (CPT code 96,413 for the initial hour and 96,415 for subsequent hours [27]). Infusion of infliximab was assumed to take 4 h [27, 28].

Statistical Methods

A network meta-analysis was conducted to assess the comparative efficacy of the six approved biologic agents for the treatment of active AS. The network meta-analysis was conducted within a Bayesian approach, as this approach can deliver both statistical estimations and a framework for probabilistic decision-making under uncertainty [16]. Using a random effects model, the number of people achieving an ASAS20 (or ASAS40) response at Week 12–16 was assumed to follow a binomial likelihood, with the corresponding probabilities being related to the treatment effects via a logit link function. Assessment of the goodness-of-fit and model diagnostics was based on the residual deviance and the deviance information criterion. Non-informative priors were applied to ensure that treatment comparisons were driven by the observed data. Estimated comparative effects were summarized using posterior medians and 95% credible intervals (CrI). Numbers needed to treat (NNT) for each additional ASAS20 or ASAS40 responder were calculated as the reciprocal of the response rate difference between the agent and placebo. The incremental cost per responder for each treatment was calculated as the product of the 12-week costs and the NNT. Given that the efficacy measures from the clinical trials are based on intent-to-treat (ITT) analysis, the incremental costs per responder calculated in this study are also based on the ITT population. All analyses were conducted using Bayesian Markov chain Monte Carlo (MCMC) with OpenBUGS 3.2.3 [16].

Compliance with Ethics Guidelines

This article is based on previously conducted studies, and does not involve any new studies of human or animal subjects performed by any of the authors.

Results

The targeted literature review identified 15 trials that met the inclusion criteria and reported ASAS20 and/or ASAS40 response rates from Week 12 to Week 16 after initiation of treatment (Table 1). Fourteen trials were placebo-controlled and one trial directly compared etanercept and infliximab [29]. Among the 14 placebo-controlled trials, adalimumab was investigated in 3 trials [9, 30, 31], certolizumab pegol in 1 trial [10], etanercept in 4 trials [11, 32–34], golimumab in 2 trials [12, 35], infliximab in 2 trials [13, 36], and secukinumab in 2 trials [37]. Figure 1 shows the evidence network of this study. All trials included were considered high quality, in terms of randomization, blinding, sample size, appropriate analysis, and data presentation, with the exception of the one open-label trial with a small sample size [29]. The majority of trials reported ASAS20 and/or ASAS40 at Week 12, with the exception of the golimumab trial which reported ASAS20 and ASAS40 at Week 14, and the secukinumab trials which reported ASAS20 and ASAS40 at Week 16. The majority of trials were multi-center with the exception of two studies in China [12, 31], one study in Italy [30], one study in Canada [30], and one study in California, US [33]. In addition to fulfilling the modified New York criteria, the majority of trials required patients to have a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) greater than or equal to 4, a spinal pain assessment score or a back pain score greater than or equal to 4 (on a 10-point visual analog scale or a 10-point numerical rating scale), and inadequate response to one or more NSAIDs. The certolizumab pegol and secukinumab trials enrolled patients with prior anti-TNF agent exposure (20% in the RAPID-axSpA trial [10], 27% in the MEASURE 1 trial [37], and 39% in the MEASURE 2 trial [37]; ClinicalTrials.gov identifiers: NCT01087762, NCT01358175, and NCT01649375, respectively), whereas all other agents were assessed in TNF-naïve populations.

Table 1

Summary of results from trials included in the network meta-analysis

Trial name	Treatment	N	ASAS20 at Week 12		ASAS40 at Week 12
			N	%	N	%
ATLAS [9]	Placebo	107	22	20.6	14	13.1
	Adalimumab 40 mg	208	121	58.2	83	39.9
M03-606 [30]	Placebo	44	12	27.3	4	9.1
	Adalimumab 40 mg	38	18	47.4	17	44.7
Huang [31]	Placebo	115	35	30.4	11	9.6
	Adalimumab 40 mg	229	154	67.2	102	44.5
RAPID-axSpA [10]	Placebo	57	21	36.8	11	19.3
	Certolizumab 200 mg	65	37	56.9	26	40.0
	Certolizumab 400 mg	56	36	64.3	28	50.0
Calin [32]	Placebo	39	9	23.1	–	–
	Etanercept 25 mg	45	27	60.0	–	–
Gorman [33]a	Placebo	20	7	35.0	–	–
	Etanercept 25 mg	20	15	75.0	–	–
Enbrel AS Study [11]	Placebo	139	39	28.1	–	–
	Etanercept 25 mg	138	82	59.4	–	–
Etanercept Study 314 [34]	Placebo	51	19	37.3	11	21.6
	Etanercept 25 mg	150	107	71.3	80	53.3
	Etanercept 50 mg	155	115	74.2	90	58.1
Giardina [29]	Etanercept 50 mg	25	15	60.0	11	43.0
	Infliximab 5 mg/kg	25	19	75.0	14	55.0
Bao [12]b	Placebo	105	26	24.8	10	9.6
	Golimumab 50 mg	108	53	49.1	29	26.9
GO-RAISE [35]c	Placebo	78	17	21.8	12	15.5
	Golimumab 50 mg	138	82	59.4	62	44.9
ASSERT [13]	Placebo	78	16	20.5	10	12.8
	Infliximab 5 mg/kg	201	124	61.9	99	49.3
Braun [36]	Placebo	35	10	27.2	–	–
	Infliximab 5 mg/kg	35	24	68.8	–	–
MEASURE 1 [37]d	Placebo	122	35	28.7	16	13.1
	Secukinumab 75 mg	124	74	59.7	41	33.1
	Secukinumab 150 mg	125	76	60.8	52	41.6
MEASURE 2 [37]d	Placebo	74	21	28.4	8	10.8
	Secukinumab 75 mg	73	30	41.1	19	26.0
	Secukinumab 150 mg	72	44	61.1	26	36.1

aIn this study, ASAS20 response was defined as 20 % or greater improvement in at least three of five outcome measures (duration of morning stiffness, degree of nocturnal spinal pain, the Bath Ankylosing Spondylitis Functional Index, the patient’s global assessment of disease activity, and the score for joint swelling)

bASAS20 responses were assessed at week 14

cEfficacy outcomes were assessed at week 14

dEfficacy outcomes were assessed at week 16

Fig. 1

Evidence network of biologic agents for treatment of active AS. A total of 15 phase III trials for active AS were identified through a targeted literature review and were included in the network. AS ankylosing spondylitis

Network Meta-Analysis: ASAS20

Patients with AS treated with infliximab had the highest probability of achieving ASAS20 (71.7%; 95% CrI 59.5–82.0%) and the lowest NNT of 2.3 (95% CrI 1.9–3.1), followed by those treated with adalimumab (ASAS20, 63.6%; NNT, 2.8), etanercept (ASAS20, 62.0%; NNT, 2.9), secukinumab (ASAS20, 60.3%; NNT, 4.0), golimumab (ASAS20, 60.2%; NNT, 3.1), and certolizumab pegol (ASAS20, 50.5%; NNT, 4.4). Infliximab had a probability of 76% of having the highest ASAS20 response among all comparators, followed by adalimumab with a 9% probability, and golimumab with a 5% probability (Fig. 2a). Incorporating the cost component, adalimumab had the lowest 12-week cost per additional ASAS20 responder at $26,888 (95% CrI $21,720–$37,320), followed by infliximab at $28,175 ($22,903–$38,694), etanercept at $28,199 ($22,483–$38,633), golimumab at $30,417 ($22,550–$49,510), secukinumab without a loading dosage at $33,847 ($25,149–$53,293), certolizumab pegol at $60,326 ($33,593–$232,542), and secukinumab with a loading dosage at $67,694 ($50,299–$106,586). Adalimumab had a probability of 38% of having the lowest cost per ASAS20 responder among all comparators, followed by etanercept with a 22% probability, infliximab with a 21% probability, and golimumab with a 14% probability (Fig. 2b). Detailed results of the network meta-analysis of ASAS20 for all agents are shown in Table 2.

Fig. 2

Ranking probabilities of biologic agents for treatment of active ankylosing spondylitis. a Ranking probabilities in ASAS20 response. b Ranking probabilities in cost per ASAS20 responder

Table 2

Number needed to treat and cost per ASAS20 responder

Treatment	Response (95% CrI)	OR (95% CrI)	NNT (95% CrI)	Cost per responder (95% CrI)
Placebo	27.9% (25.3%, 30.6%)	–	–	–
Adalimumab	63.6% (53.2%, 72.5%)	4.5 (3.0, 6.7)	2.8 (2.3, 3.9)	$26,888 ($21,720, $37,320)
Certolizumab pegola	50.5% (32.9%, 68.4%)	2.6 (1.3, 5.5)	4.4 (2.5, 17.0)	$60,326 ($33,593, $232,542)
Etanerceptb	62.0% (52.3%, 71.1%)	4.2 (2.9, 6.2)	2.9 (2.3, 4.0)	$28,199 ($22,483, $38,633)
Golimumab	60.2% (47.4%, 71.8%)	3.9 (2.4, 6.5)	3.1 (2.3, 5.0)	$30,417 ($22,550, $49,510)
Infliximabc	71.7% (59.5%, 82.0%)	6.6 (3.9, 11.6)	2.3 (1.9, 3.1)	$28,175 ($22,903, $38,694)
Secukinumab (without loading)d	60.3% (48.1%, 71.8%)	4.0 (2.3, 6.6)	3.1 (2.3, 5.1)	$33,847 ($25,149, $53,293)
Secukinumab (with loading)d	60.3% (48.1%, 71.8%)	4.0 (2.3, 6.6)	3.1 (2.3, 5.1)	$67,694 ($50,299, $106,586)

ASAS20 assessment in ankylosing spondylitis 20% response, CrI credible interval, NNT number needed to treat, OR odds ratio

Efficacies were estimated based on a random effects network meta-analysis using a binomial model

aCertolizumab pegol 200 mg every 2 weeks and 400 mg every 4 weeks were treated as equivalent therapeutic doses

bEtanercept 25 mg twice a week and 50 mg every week were treated as equivalent therapeutic doses

cDrug cost of infliximab was based on an 80 kg adult

dAssumes that the efficacy of secukinumab 150 mg was equivalent with and without a loading dose

Network Meta-Analysis: ASAS40

Patients with AS treated with infliximab had the highest probability of achieving ASAS40 (51.5%; 95% CrI 33.4–70.0%) and the lowest NNT of 2.6 (95% CrI 1.8–4.9), followed by adalimumab (ASAS40, 49.2%; NNT, 2.8), secukinumab (ASAS40, 42.4%; NNT, 3.5), etanercept (ASAS40, 41.4%; NNT, 3.6), golimumab (ASAS40, 38.6%; NNT, 4.0), and certolizumab pegol (ASAS40, 34.8%; NNT, 4.7). Infliximab had a probability of 48% of having the highest ASAS40 response among all comparators, followed by adalimumab with a probability of 29%, secukinumab with a 9% probability, and etanercept with a 6% probability. Incorporating the cost component, adalimumab had the lowest 12-week cost per additional ASAS40 responder at $26,898 (95% CrI $19,483–$41,699), followed by infliximab at $32,508 ($21,954–$60,308), etanercept at $34,406 ($20,866–$76,436), secukinumab without a loading dosage at $37,850 ($24,274–$72,096), golimumab at $39,030 ($23,760–$83,570), certolizumab pegol at $64,051 ($31,815–$227,020), and secukinumab with a loading dosage at $75,701 ($48,547–$144,191). Adalimumab had a probability of 56% of having the lowest cost per ASAS40 responder among all comparators, followed by infliximab with a 17% probability, etanercept with a 14% probability, secukinumab without a loading dosage with a 7% probability, and golimumab with a 6% probability. Detailed results of the network meta-analysis of ASAS40 for all agents are shown in Table 3.

Table 3

Number needed to treat and cost per ASAS40 responder

Treatment	Response (95% CrI)	OR(95% CrI)	NNT(95% CrI)	Cost per responder(95% CrI)
Placebo	13.5% (11.4%, 15.9%)	–	–	–
Adalimumab	49.2% (36.0%, 63.4%)	6.2 (3.8, 10.8)	2.8 (2.0, 4.3)	$26,898 ($19,483, $41,699)
Certolizumab pegola	34.8% (18.8%, 56.2%)	3.4 (1.5, 8.1)	4.7 (2.3, 16.6)	$64,051 ($31,815, $227,020)
Etanerceptb	41.4% (25.6%, 60.1%)	4.6 (2.3, 9.3)	3.6 (2.2, 8.0)	$34,406 ($20,866, $76,436)
Golimumab	38.6% (24.5%, 55.5%)	4.0 (2.2, 7.8)	4.0 (2.4, 8.5)	$39,030 ($23,760, $83,570)
Infliximabc	51.5% (33.4%, 70.0%)	6.8 (3.3, 14.8)	2.6 (1.8, 4.9)	$32,508 ($21,954, $60,308)
Secukinumab (without loading)d	42.4% (28.1%, 59.2%)	4.7 (2.6, 9.1)	3.5 (2.2, 6.6)	$37,850 ($24,274, $72,096)
Secukinumab (with loading)d	42.4% (28.1%, 59.2%)	4.7 (2.6, 9.1)	3.5 (2.2, 6.6)	$75,701 ($48,547, $144,191)

ASAS40 assessment in ankylosing spondylitis 40% response, CrI credible interval, NNT number needed to treat, OR odds ratio

Efficacies were estimated based on a random effects network meta-analysis using a binomial model

aCertolizumab pegol 200 mg every 2 weeks and 400 mg every 4 weeks were treated as equivalent therapeutic doses

bEtanercept 25 mg twice a week and 50 mg every week were treated as equivalent therapeutic doses

cDrug cost of infliximab was based on an 80 kg adult

dAssumes that the efficacy of secukinumab 150 mg was equivalent with and without a loading dose

Discussion

The primary goal of AS treatment is to relieve symptoms, maintain physical function, and prevent complications [1]. The assessment in ankylosing spondylitis (ASAS) group recommended that physical function, spinal pain, patient global assessment, and inflammation to be the core set of criteria to evaluate AS treatment response, and used them to construct composite criteria for use in AS trials [38]. ASAS20 and ASAS40 are among these composite criteria, which have been validated in previous studies of TNF blockers and are widely used in AS clinical trials [39]. In the current network meta-analysis of biologic treatments for active AS, infliximab had the lowest NNT to achieve an additional ASAS20/40 response, and adalimumab had the lowest 12-week cost per ASAS20/40 responder.

Previous research has assessed the efficacy of different biologic agents in the treatment of AS using conventional pairwise meta-analyses. One study compared adalimumab, etanercept, and infliximab with placebo, and found that these TNF inhibitors had significantly better efficacy than placebo, in terms of pain, physical function, patient’s global assessment, and acute phase reactants [40]. Other more recent studies assessed the efficacy of TNF blockers as a class by pooling studies of different agents together (adalimumab, certolizumab pegol, etanercept, golimumab, and infliximab) [3, 14, 41]. In those studies, TNF inhibitors showed better efficacy than placebo for BASDAI, Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI), ASAS20, ASAS40, ASAS50, and ASAS70 response among patients with AS. One previous indirect comparison study assessed the relative efficacies among adalimumab, etanercept, golimumab, and infliximab [42]. However, that study only evaluated ASAS20 and did not include the newer biologic agents (certolizumab pegol and secukinumab); moreover, it did not take drug cost into consideration in the comparisons. A recent report by the National Institute for Health and Care Excellence (NICE) assessed data from sixteen randomized clinical trials via a network meta-analysis and compared the efficacy of adalimumab, certolizumab pegol, etanercept, golimumab, and infliximab in the treatment of AS [43]. The results in the NICE report are in line with the ones presented in this study, in terms of both ASAS20 and ASAS40 (that report did not include data regarding the newer agent secukinumab). The current analyses are the first to compare the efficacy and cost-effectiveness among a comprehensive list of novel biologic agents for active AS treatment. This study indicated that adalimumab had the lowest overall cost per responder in the treatment of active AS (when considering both ASAS20 and ASAS40 response), which is consistent with previous studies regarding the cost per responder associated with biologic therapies for Crohn’s disease, psoriasis, and rheumatoid arthritis [44, 45].

The recently published 2015 American College of Rheumatology (ACR)/Spondylitis Association of America (SAA)/Spondyloarthritis Research and Treatment Network (SPARTAN) guidelines for the treatment of AS recommend TNF inhibitors in adults with AS when activity persists despite treatment with NSAIDs [46]. The guidelines do not recommend a particular TNF inhibitor, except in patients with AS and inflammatory bowel disease where treatment with TNF inhibitory monoclonal antibodies (such as adalimumab or infliximab) is preferred over etanercept. While the guidelines do not include secukinumab, the FDA suggested cautious use of secukinumab in patients with inflammatory bowel disease due to exacerbations observed during the clinical trials [8].

As in other indirect comparison studies, this network meta-analysis also has some limitations. Given the small numbers of eligible trials for each pairwise comparison in the network, appropriate adjustment of baseline risks for each trial was rendered impossible. In addition, although the network meta-analysis synthesizes results from randomized clinical trials, the comparative efficacy was mostly based on indirect evidence, and may be influenced by potentially observed or unobserved differences across the trials. However, this network meta-analysis represents the best evidence available for the comparative efficacy of biologic treatment for active AS, and this information is crucial for health technology assessment and other decision-making in this field. In addition, this study included one open-label trial with limited sample size comparing etanercept with infliximab [29]. The responses reported in this trial, however, are similar to the results from the current network meta-analysis. Therefore, including this study will not significantly affect the estimates in this study and may in fact strengthen the analysis by directly linking two of the biologic agents.

Most of the AS clinical trials included in this analysis allowed concomitant use of DMARDs (e.g., sulfasalazine, methotrexate) and corticosteroids; however, the cost per responder analyses include only the biologic drug costs (and associated administration cost). This study did not consider direct medical costs associated with treatment, such as those associated with hospitalization and rheumatology visits. Moreover, this analysis did not compare safety and tolerability outcomes, and thus, did not include subsequent costs associated with potential adverse events. Nonetheless, most of the biologic agents did not show significantly different rates of serious adverse events compared with placebo (except for certolizumab pegol) in a Cochran meta-analysis of clinical trials data [47], and rates of concomitant use of DMARDs and corticosteroids were similar across trials so the inclusion of these outcomes and associated costs would be unlikely to alter the conclusions of this study. To be consistent with the primary endpoints of AS clinical trials, this study only considers 12-week costs for all treatments and does not speculate on the cost-effectiveness over longer periods of treatment. Future economic modeling studies may be helpful in understanding the full picture of healthcare costs associated with biologic treatments of AS. Lastly, the lack of certolizumab pegol trial results stratified by previous TNF inhibitor exposure limited the ability to conduct the analysis in a pure TNF-naïve population. As the proportion of patients with prior TNF exposure is relatively small and the exposure would affect both the placebo and the active agent, the results are unlikely to be markedly affected by the inclusion of TNF-experienced patients for certolizumab pegol and secukinumab.

Conclusions

The current analyses are the first to compare the efficacy and cost-effectiveness among all available biologic agents for the treatment of active AS. In these analyses, adalimumab and infliximab demonstrated higher efficacy and lower cost per responder in terms of both ASAS20 and ASAS40. The study results indicate the potential for these agents to be used more cost-effectively in the treatment of active AS.