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Literature DB >> 2774703

Fatal aplastic anaemia and liver toxicity caused by D-penicillamine treatment of rheumatoid arthritis.

Abstract

A 65 year old woman with rheumatoid arthritis developed marrow aplasia and jaundice owing to D-penicillamine treatment. Recovery of bone marrow was ineffective, and the patient finally died despite intensive therapeutic measures. The rare coexistence of myelotoxicity and hepatotoxicity is presented and discussed.

Entities: Chemical Disease Species

Mesh：

Substances：
Penicillamine

Year: 1989 PMID： 2774703 PMCID： PMC1003826 DOI： 10.1136/ard.48.7.609

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

9 in total

1. RHEUMATOID ARTHRITIS WITH ARTERITIS; REPORT OF A CASE TREATED WITH PENICILLAMINE.

Authors: I A JAFFE
Journal: Ann Intern Med Date: 1964-09 Impact factor: 25.391

2. Is penicillamine therapy in rheumatoid arthritis influenced by previous treatment with gold?

Authors: M Webley; E N Coomes
Journal: Br Med J Date: 1978-07-08

3. Myelotoxicity of D-penicillamine.

Authors: A G Kay
Journal: Ann Rheum Dis Date: 1979-06 Impact factor: 19.103

4. Cholestatic jaundice caused by D-penicillamine.

Authors: D Barzilai; G Dickstein; R Enat; H Bassan; C Lichtig; B Gellei
Journal: Ann Rheum Dis Date: 1978-02 Impact factor: 19.103

5. Toxicity of D-penicillamine in rheumatoid arthritis. A report of 63 patients including two with aplastic anemia and one with the nephrotic syndrome.

Authors: A S Weiss; J A Markenson; M S Weiss; W H Kammerer
Journal: Am J Med Date: 1978-01 Impact factor: 4.965

6. D-Penicillamine induced toxicity in rheumatoid arthritis: the role of sulphoxidation status and HLA-DR3.

Authors: P Emery; G S Panayi; G Huston; K I Welsh; S C Mitchell; R R Shah; J R Idle; R L Smith; R H Waring
Journal: J Rheumatol Date: 1984-10 Impact factor: 4.666

7. Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.

Authors: J Rosenbaum; W A Katz; H R Schumacher
Journal: Ann Rheum Dis Date: 1980-04 Impact factor: 19.103

8. Genetic basis of rheumatoid disease: HLA antigens, disease manifestations, and toxic reactions to drugs.

Authors: G S Panayi; P Wooley; J R Batchelor
Journal: Br Med J Date: 1978-11-11

9 in total

4 in total

Fatal aplastic anaemia and liver toxicity caused by D-penicillamine treatment of rheumatoid arthritis.

1. RHEUMATOID ARTHRITIS WITH ARTERITIS; REPORT OF A CASE TREATED WITH PENICILLAMINE.

2. Is penicillamine therapy in rheumatoid arthritis influenced by previous treatment with gold?

3. Myelotoxicity of D-penicillamine.

4. Cholestatic jaundice caused by D-penicillamine.

5. Toxicity of D-penicillamine in rheumatoid arthritis. A report of 63 patients including two with aplastic anemia and one with the nephrotic syndrome.

6. D-Penicillamine induced toxicity in rheumatoid arthritis: the role of sulphoxidation status and HLA-DR3.

7. Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.

8. Genetic basis of rheumatoid disease: HLA antigens, disease manifestations, and toxic reactions to drugs.

1. Antithymocyte globulin in the treatment of D-penicillamine-induced aplastic anemia.

2. Pure red cell aplasia caused by D-penicillamine treatment of rheumatoid arthritis.

3. Aplastic anemia, membranous nephropathy and mercury.

Review 4. Ethnopharmacological Approaches for Therapy of Jaundice: Part I.