| Literature DB >> 27743438 |
Maryam Beheshtian1, Mojgan Babanejad1, Hela Azaiez2, Niloofar Bazazzadegan1, Diana Kolbe2, Christina Sloan-Heggen2, Sanaz Arzhangi1, Kevin Booth2, Marzieh Mohseni1, Kathy Frees2, Mohammad Hossein Azizi3, Ahmad Daneshi4, Mohammad Farhadi4, Kimia Kahrizi1, Richard Jh Smith2, Hossein Najmabadi1.
Abstract
A significant contribution to the causes of hereditary hearing impairment comes from genetic factors. More than 120 genes and 160 loci have been identified to be involved in hearing impairment. Given that consanguine populations are more vulnerable to most inherited diseases, such as hereditary hearing loss (HHL), the genetic picture of HHL among the Iranian population, which consists of at least eight ethnic subgroups with a high rate of intermarriage, is expected to be highly heterogeneous. Using an electronic literature review through various databases such as PubMed, MEDLINE, and Scopus, we review the current picture of HHL in Iran. In this review, we present more than 39 deafness genes reported to cause non-syndromic HHL in Iran, of which the most prevalent causative genes include GJB2, SLC26A4, MYO15A, and MYO7A. In addition, we highlight some of the more common genetic causes of syndromic HHL in Iran. These results are of importance for further investigation and elucidation of the molecular basis of HHL in Iran and also for developing a national diagnostic tool tailored to the Iranian context enabling early and efficient diagnosis of hereditary hearing impairment.Entities:
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Year: 2016 PMID： 27743438 PMCID： PMC5541368 DOI： 0161910/AIM.0010
Source DB: PubMed Journal: Arch Iran Med ISSN： 1029-2977 Impact factor: 1.354