Nicole K Scripsema1, Patricia M Garcia1, Richard D Bavier2, Toco Y P Chui1, Brian D Krawitz1, Shelley Mo1, Steven A Agemy3, Luna Xu1, Yijie B Lin1, Joseph F Panarelli1, Paul A Sidoti1, James C Tsai1, Richard B Rosen1. 1. Department of Ophthalmology, The New York Eye and Ear Infirmary of Mount Sinai and Icahn School of Medicine at Mount Sinai, New York, New York, United States. 2. Department of Ophthalmology, The New York Eye and Ear Infirmary of Mount Sinai and Icahn School of Medicine at Mount Sinai, New York, New York, United States 2Rutgers New Jersey Medical School, Newark, New Jersey, United States. 3. Department of Ophthalmology, The New York Eye and Ear Infirmary of Mount Sinai and Icahn School of Medicine at Mount Sinai, New York, New York, United States 3Department of Ophthalmology, SUNY Downstate Medical Center and SUNY Downstate College of Medicine, Brooklyn, New York, United States.
Abstract
Purpose: To compare perfused peripapillary capillary density in primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal patients using optical coherence tomography angiography (OCT-A). Methods: A retrospective review of POAG, NTG, and normal patients imaged with OCT-A was performed. En face OCT angiograms identifying peripapillary vessels were obtained using a spectral-domain OCT system (Avanti RTVue-XR). A custom image analysis approach identified perfused peripapillary capillaries, quantified perfused capillary density (PCD), and generated color-coded PCD maps for 3.5- and 4.5-mm-diameter scans. We compared PCD values, PCD maps, standard automated perimetry (Humphrey visual field [HVF]) parameters, and OCT retinal nerve fiber layer (RNFL) thickness analyses across all groups. Results: Forty POAG, 26 NTG, and 26 normal patients were included. Annular PCD in POAG (34.24 ± 6.76%) and NTG (37.75 ± 3.52%) patients was significantly decreased compared to normal patients (42.99 ± 1.81%) in 4.5-mm scans (P < 0.01 and P < 0.01, respectively). Similar trends and statistical significances were seen in 3.5-mm scans. Linear regression analysis resulted in moderate correlations between annular PCD values and other glaucomatous parameters. Pearson coefficients comparing annular PCD from 4.5-mm scans in POAG and NTG groups to HVF mean deviation, HVF pattern standard deviation, and average RNFL thickness all showed statistical significance (P < 0.05). Color maps showed that POAG and NTG patients had a reduction of perfused capillaries that progressed in size when comparing early, moderate, and severe glaucoma groups. Conclusions: Optical coherence tomography angiography can uniquely identify changes in peripapillary PCD in glaucoma patients. Optical coherence tomography angiography may offer insights into the pathophysiology of glaucomatous damage and risk factors for disease progression.
Purpose: To compare perfused peripapillary capillary density in primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal patients using optical coherence tomography angiography (OCT-A). Methods: A retrospective review of POAG, NTG, and normal patients imaged with OCT-A was performed. En face OCT angiograms identifying peripapillary vessels were obtained using a spectral-domain OCT system (Avanti RTVue-XR). A custom image analysis approach identified perfused peripapillary capillaries, quantified perfused capillary density (PCD), and generated color-coded PCD maps for 3.5- and 4.5-mm-diameter scans. We compared PCD values, PCD maps, standard automated perimetry (Humphrey visual field [HVF]) parameters, and OCT retinal nerve fiber layer (RNFL) thickness analyses across all groups. Results: Forty POAG, 26 NTG, and 26 normal patients were included. Annular PCD in POAG (34.24 ± 6.76%) and NTG (37.75 ± 3.52%) patients was significantly decreased compared to normal patients (42.99 ± 1.81%) in 4.5-mm scans (P < 0.01 and P < 0.01, respectively). Similar trends and statistical significances were seen in 3.5-mm scans. Linear regression analysis resulted in moderate correlations between annular PCD values and other glaucomatous parameters. Pearson coefficients comparing annular PCD from 4.5-mm scans in POAG and NTG groups to HVF mean deviation, HVF pattern standard deviation, and average RNFL thickness all showed statistical significance (P < 0.05). Color maps showed that POAG and NTG patients had a reduction of perfused capillaries that progressed in size when comparing early, moderate, and severe glaucoma groups. Conclusions: Optical coherence tomography angiography can uniquely identify changes in peripapillary PCD in glaucomapatients. Optical coherence tomography angiography may offer insights into the pathophysiology of glaucomatous damage and risk factors for disease progression.
Authors: Yanin Suwan; Masoud Aghsaei Fard; Lawrence S Geyman; Apichat Tantraworasin; Toco Y Chui; Richard B Rosen; Robert Ritch Journal: JAMA Ophthalmol Date: 2018-05-01 Impact factor: 7.389
Authors: Rafaella Nascimento E Silva; Carolina A Chiou; Mengyu Wang; Haobing Wang; Marissa K Shoji; Jonathan C Chou; Erica E D'Souza; Scott H Greenstein; Stacey C Brauner; Milton R Alves; Louis R Pasquale; Lucy Q Shen Journal: J Glaucoma Date: 2019-04 Impact factor: 2.503
Authors: Davis B Zhou; Maria V Castanos; Alexander Pinhas; Peter Gillette; Justin V Migacz; Richard B Rosen; Jeffrey Glassberg; Toco Y P Chui Journal: Biomed Opt Express Date: 2021-04-21 Impact factor: 3.732
Authors: Rafaella C Penteado; Linda M Zangwill; Fábio B Daga; Luke J Saunders; Patricia I C Manalastas; Takuhei Shoji; Tadamichi Akagi; Mark Christopher; Adeleh Yarmohammadi; Sasan Moghimi; Robert N Weinreb Journal: J Glaucoma Date: 2018-06 Impact factor: 2.503