F Salazar Meira1, J Zemiacki2, A E Figueiredo3, L Viliano Kroth3, D Saute Kochhann3, D O d'Avila3, M Traesel3, D Saitovitch3, C E Poli-de-Figueiredo3. 1. Programa de Pós-graduação em Medicina e Ciências da Saúde da Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Nephrology: FAMED, FAENFI, IPB, HSL, Porto Alegre, Brazil. Electronic address: salazarfernanda@yahoo.com.br. 2. Programa de Pós-graduação em Medicina e Ciências da Saúde da Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Nephrology: FAMED, FAENFI, IPB, HSL, Porto Alegre, Brazil; Faculdade de Ciências Econômicas. Master in Economia Aplicada. Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. 3. Programa de Pós-graduação em Medicina e Ciências da Saúde da Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Nephrology: FAMED, FAENFI, IPB, HSL, Porto Alegre, Brazil.
Abstract
BACKGROUND: One of the main postoperative complications of kidney transplant is delayed graft function (DGF), which means absence of graft function after transplant or the need for dialysis during the first week post procedure. The occurrence of DGF currently in our hospital is high and has been attributed to a combination of many factors. The aim of this study was to evaluate the factors associated to DGF and their influence in the outcome of kidney transplants. METHODS: Historical cohort of 150 patients transplanted with live or deceased donor kidneys from 2011 to 2013. RESULTS: DGF was associated to time in dialysis and the number of recipient pre-transplant transfusions, donors age, serum creatinine level, use of vasoactive drugs in the donor, distance from place of organ retrieval and transplant center, and duration of cold ischemia time. DGF influenced post-transplantation outcome in regard to length of stay in intensive care, length of hospital stay, acute rejection episodes, and higher creatinine levels at discharge. Patients and graft survival were shorter in the DGF group. CONCLUSIONS: There are multiple factors related to DGF, the most important being those related to donors, and organ storage. The most important factor related to the recipient was the dialysis vintage. We did not find a correlation between DGF and HLA-compatibility. DGF consequences are important, including worse graft function and survival, as well as impact in recipient morbidity and mortality.
BACKGROUND: One of the main postoperative complications of kidney transplant is delayed graft function (DGF), which means absence of graft function after transplant or the need for dialysis during the first week post procedure. The occurrence of DGF currently in our hospital is high and has been attributed to a combination of many factors. The aim of this study was to evaluate the factors associated to DGF and their influence in the outcome of kidney transplants. METHODS: Historical cohort of 150 patients transplanted with live or deceased donor kidneys from 2011 to 2013. RESULTS: DGF was associated to time in dialysis and the number of recipient pre-transplant transfusions, donors age, serum creatinine level, use of vasoactive drugs in the donor, distance from place of organ retrieval and transplant center, and duration of cold ischemia time. DGF influenced post-transplantation outcome in regard to length of stay in intensive care, length of hospital stay, acute rejection episodes, and higher creatinine levels at discharge. Patients and graft survival were shorter in the DGF group. CONCLUSIONS: There are multiple factors related to DGF, the most important being those related to donors, and organ storage. The most important factor related to the recipient was the dialysis vintage. We did not find a correlation between DGF and HLA-compatibility. DGF consequences are important, including worse graft function and survival, as well as impact in recipient morbidity and mortality.
Authors: Peter Urbanellis; Dagmar Kollmann; Ivan Linares; Sujani Ganesh; Fabiola Oquendo; Laura Mazilescu; Toru Goto; Yuki Noguchi; Rohan John; Ana Konvalinka; Istvan Mucsi; Anand Ghanekar; Darius Bagli; Markus Selzner; Lisa A Robinson Journal: Transplant Direct Date: 2020-07-22
Authors: Nicholas V Mendez; Yehuda Raveh; Joshua J Livingstone; Gaetano Ciancio; Giselle Guerra; George W Burke Iii; Vadim B Shatz; Fouad G Souki; Linda J Chen; Mahmoud Morsi; Jose M Figueiro; Tony M Ibrahim; Werviston L DeFaria; Ramona Nicolau-Raducu Journal: World J Transplant Date: 2021-04-18
Authors: Tássia Louise Sousa Augusto de Morais; Karla Simone Costa de Souza; Mabelle Alves Ferreira de Lima; Maurício Galvão Pereira; José Bruno de Almeida; Antônio Manuel Gouveia de Oliveira; Karine Cavalcanti Mauricio Sena-Evangelista; Adriana Augusto de Rezende Journal: PLoS One Date: 2022-08-04 Impact factor: 3.752
Authors: Peter Urbanellis; Caitriona M McEvoy; Marko Škrtić; J Moritz Kaths; Dagmar Kollmann; Ivan Linares; Sujani Ganesh; Fabiola Oquendo; Manraj Sharma; Laura Mazilescu; Toru Goto; Yuki Noguchi; Rohan John; Istvan Mucsi; Anand Ghanekar; Darius Bagli; Ana Konvalinka; Markus Selzner; Lisa A Robinson Journal: Transplant Direct Date: 2021-07-08