Michael Messerli1, Fabian Rengier2, Lotus Desbiolles3, Niklas F Ehl4, Ralf W Bauer3, Sebastian Leschka5, Hatem Alkadhi6, Simon Wildermuth3, Claas P Nähle3. 1. Division of Radiology and Nuclear Medicine, Cantonal Hospital St. Gallen, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland. Electronic address: Michael.Messerli@kssg.ch. 2. Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Germany. 3. Division of Radiology and Nuclear Medicine, Cantonal Hospital St. Gallen, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland. 4. Department of Cardiology, Cantonal Hospital St. Gallen, Switzerland. 5. Division of Radiology and Nuclear Medicine, Cantonal Hospital St. Gallen, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland; Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, University Zurich, Switzerland. 6. Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, University Zurich, Switzerland.
Abstract
RATIONALE AND OBJECTIVES: To evaluate the influence of advanced modeled iterative reconstruction (ADMIRE) on the coronary artery calcium (CAC) scores by computed tomography (CT). MATERIALS AND METHODS: Sixty patients underwent CAC imaging with dual-source 192-slice CT. Agatston, volume and mass score were calculated from filtered back projection (FBP) and iterative reconstructions with different levels of ADMIRE. Friedman test and Wilcoxon rank sum test were used for multiple comparisons of CAC values and the difference ratio among different ADMIRE groups using FBP as reference. RESULTS: The median Agatston score (range) using FBP was 115 (0.1-3047) and significantly decreased with incremental ADMIRE levels 1-5: 96 (0.1-2813), 91 (0-2764), 87 (0-2699), 80 (0-2590), 70 (0-2440); all P < 0.001. In comparison with FBP Agatston, volume and mass scores significantly decreased with increasing ADMIRE levels 1-5 (P < 0.001): from -12% to -39%, from -14% to -41%, and from -13% to -40%, respectively. In four patients with low calcium burden, the use of ADMIRE 2 or higher resulted in the disappearance of calcium that was detectable using FBP or ADMIRE 1. The decrease of CAC in high-level ADMIRE resulted in a reassignment to a lower Agatston risk group in 27%. CONCLUSIONS: ADMIRE causes a substantial reduction of the CAC scores measured by cardiac CT, which leads to an underestimation of cardiovascular risk scores in some patients.
RATIONALE AND OBJECTIVES: To evaluate the influence of advanced modeled iterative reconstruction (ADMIRE) on the coronary artery calcium (CAC) scores by computed tomography (CT). MATERIALS AND METHODS: Sixty patients underwent CAC imaging with dual-source 192-slice CT. Agatston, volume and mass score were calculated from filtered back projection (FBP) and iterative reconstructions with different levels of ADMIRE. Friedman test and Wilcoxon rank sum test were used for multiple comparisons of CAC values and the difference ratio among different ADMIRE groups using FBP as reference. RESULTS: The median Agatston score (range) using FBP was 115 (0.1-3047) and significantly decreased with incremental ADMIRE levels 1-5: 96 (0.1-2813), 91 (0-2764), 87 (0-2699), 80 (0-2590), 70 (0-2440); all P < 0.001. In comparison with FBP Agatston, volume and mass scores significantly decreased with increasing ADMIRE levels 1-5 (P < 0.001): from -12% to -39%, from -14% to -41%, and from -13% to -40%, respectively. In four patients with low calcium burden, the use of ADMIRE 2 or higher resulted in the disappearance of calcium that was detectable using FBP or ADMIRE 1. The decrease of CAC in high-level ADMIRE resulted in a reassignment to a lower Agatston risk group in 27%. CONCLUSIONS: ADMIRE causes a substantial reduction of the CAC scores measured by cardiac CT, which leads to an underestimation of cardiovascular risk scores in some patients.
Authors: Michael Messerli; Andreas A Giannopoulos; Sebastian Leschka; René Warschkow; Simon Wildermuth; Lukas Hechelhammer; Ralf W Bauer Journal: Br J Radiol Date: 2017-10-03 Impact factor: 3.039
Authors: Angeliki Neroladaki; Steve Philippe Martin; Ilias Bagetakos; Diomidis Botsikas; Marion Hamard; Xavier Montet; Sana Boudabbous Journal: Medicine (Baltimore) Date: 2019-02 Impact factor: 1.817
Authors: Andreas Steven Kunz; Theresa Sophie Patzer; Jan-Peter Grunz; Karsten Sebastian Luetkens; Viktor Hartung; Robin Hendel; Tabea Fieber; Franca Genest; Süleyman Ergün; Thorsten Alexander Bley; Henner Huflage Journal: Sci Rep Date: 2022-09-16 Impact factor: 4.996
Authors: Claudia Morf; Thomas Sartoretti; Antonio G Gennari; Alexander Maurer; Stephan Skawran; Andreas A Giannopoulos; Elisabeth Sartoretti; Moritz Schwyzer; Alessandra Curioni-Fontecedro; Catherine Gebhard; Ronny R Buechel; Philipp A Kaufmann; Martin W Huellner; Michael Messerli Journal: Diagnostics (Basel) Date: 2022-08-03