Literature DB >> 277360

The definition of transcription units for mRNA.

J E Darnell, R Evans, N Fraser, S Goldberg, J Nevins, M Salditt-Georgieff, H Schwartz, J Weber, E Ziff.   

Abstract

The detailed analysis of TUs with purified Ad2 DNA and the analysis of TU size for the bulk HeLa cell hnRNA compared to the size of mRNA of infected and uninfected cells supports the conclusion that mRNA in mammalian cells is generally derived by the processing of primary transcripts. In the context of this volume, these results indicate that the RNA transcription products of chromatin which are related to mRNA are longer than the mRNA itself. Proper functioning of chromatin in vitro must eventually take these results into account.

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Year:  1978        PMID: 277360     DOI: 10.1101/sqb.1978.042.01.054

Source DB:  PubMed          Journal:  Cold Spring Harb Symp Quant Biol        ISSN: 0091-7451


  2 in total

1.  Joys and surprises of a career studying eukaryotic gene expression.

Authors:  James E Darnell
Journal:  J Biol Chem       Date:  2013-03-22       Impact factor: 5.157

Review 2.  Termination of Transcription of Short Noncoding RNAs by RNA Polymerase II.

Authors:  Karen M Arndt; Daniel Reines
Journal:  Annu Rev Biochem       Date:  2015-03-26       Impact factor: 23.643

  2 in total

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