Literature DB >> 23525107

Joys and surprises of a career studying eukaryotic gene expression.

James E Darnell1.   

Abstract

In this Reflections, I review a few early and very lucky events that gave me a running start for the rest of a long and wonderfully enjoyable career. For the main part, a discussion is provided of what I recall as the main illuminating results that my many dozens of students and postdoctoral fellows (approximately 140 in all) provided to our biochemical/molecular biological world.

Keywords:  Adenovirus RNAs; MicroRNA; Nuclear RNA; Poliovirus RNA; Pre-rRNA; Pre-tRNA; RNA; Ribosomal RNA (rRNA); STATs; mRNA

Mesh:

Year:  2013        PMID: 23525107      PMCID: PMC3642338          DOI: 10.1074/jbc.X113.471722

Source DB:  PubMed          Journal:  J Biol Chem        ISSN: 0021-9258            Impact factor:   5.157


  92 in total

1.  Genetic regulatory mechanisms in the synthesis of proteins.

Authors:  F JACOB; J MONOD
Journal:  J Mol Biol       Date:  1961-06       Impact factor: 5.469

2.  Unstable ribonucleic acid revealed by pulse labelling of Escherichia coli.

Authors:  F GROS; H HIATT; W GILBERT; C G KURLAND; R W RISEBROUGH; J D WATSON
Journal:  Nature       Date:  1961-05-13       Impact factor: 49.962

3.  Induction of a mutation in poliovirus by nitrous acid.

Authors:  A BOEYE
Journal:  Virology       Date:  1959-12       Impact factor: 3.616

4.  Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.

Authors:  A F Wilks; A G Harpur; R R Kurban; S J Ralph; G Zürcher; A Ziemiecki
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

5.  The definition of transcription units for mRNA.

Authors:  J E Darnell; R Evans; N Fraser; S Goldberg; J Nevins; M Salditt-Georgieff; H Schwartz; J Weber; E Ziff
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1978

6.  Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication.

Authors:  L Philipson; R Wall; G Glickman; J E Darnell
Journal:  Proc Natl Acad Sci U S A       Date:  1971-11       Impact factor: 11.205

7.  Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms.

Authors:  R G Roeder; W J Rutter
Journal:  Nature       Date:  1969-10-18       Impact factor: 49.962

8.  Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA.

Authors:  G M Ringold; K R Yamamoto; J M Bishop; H E Varmus
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

9.  Role of STAT2 in the alpha interferon signaling pathway.

Authors:  S Leung; S A Qureshi; I M Kerr; J E Darnell; G R Stark
Journal:  Mol Cell Biol       Date:  1995-03       Impact factor: 4.272

10.  Spliced segments at the 5' terminus of adenovirus 2 late mRNA.

Authors:  S M Berget; C Moore; P A Sharp
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

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  1 in total

1.  Investigating Viruses during the Transformation of Molecular Biology.

Authors:  Bernard Moss
Journal:  J Biol Chem       Date:  2017-01-30       Impact factor: 5.157

  1 in total

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