Sarah K B Bick1,2, Bradley S Folley1,3, Jutta S Mayer4,5, Sohee Park4, P David Charles6, Corrie R Camalier1, Srivatsan Pallavaram7, Peter E Konrad1, Joseph S Neimat1. 1. Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA. 2. Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA. 3. Norton Neuroscience Institute, Louisville, KY, USA. 4. Department of Psychology, Vanderbilt University, Nashville, TN, USA. 5. Department of Psychology, University of Frankfurt, Frankfurt, Germany. 6. Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. 7. Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA.
Abstract
OBJECTIVES: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms in advanced Parkinson's disease. STN DBS may also affect emotion, possibly by impacting a parallel limbic cortico-striatal circuit. The objective of this study was to investigate changes in prefrontal cortical activity related to DBS during an emotion induction task. MATERIALS AND METHODS: We used near infrared spectroscopy to monitor prefrontal cortex hemodynamic changes during an emotion induction task. Seven DBS patients were tested sequentially in the stimulation-on and stimulation-off states while on dopaminergic medication. Patients watched a series of positive, negative, and neutral videos. The general linear model was used to compare prefrontal oxygenated hemoglobin concentration between DBS states. RESULTS: Deep brain stimulation was correlated with prefrontal oxygenated hemoglobin changes relative to the stimulation off state in response to both positive and negative videos. These changes were specific to emotional stimuli and were not seen during neutral stimuli. CONCLUSIONS: These results suggest that STN stimulation influences the prefrontal cortical representation of positive and negative emotion induction.
OBJECTIVES: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms in advanced Parkinson's disease. STN DBS may also affect emotion, possibly by impacting a parallel limbic cortico-striatal circuit. The objective of this study was to investigate changes in prefrontal cortical activity related to DBS during an emotion induction task. MATERIALS AND METHODS: We used near infrared spectroscopy to monitor prefrontal cortex hemodynamic changes during an emotion induction task. Seven DBS patients were tested sequentially in the stimulation-on and stimulation-off states while on dopaminergic medication. Patients watched a series of positive, negative, and neutral videos. The general linear model was used to compare prefrontal oxygenated hemoglobin concentration between DBS states. RESULTS: Deep brain stimulation was correlated with prefrontal oxygenated hemoglobin changes relative to the stimulation off state in response to both positive and negative videos. These changes were specific to emotional stimuli and were not seen during neutral stimuli. CONCLUSIONS: These results suggest that STN stimulation influences the prefrontal cortical representation of positive and negative emotion induction.
Authors: Kenneth A Follett; Frances M Weaver; Matthew Stern; Kwan Hur; Crystal L Harris; Ping Luo; William J Marks; Johannes Rothlind; Oren Sagher; Claudia Moy; Rajesh Pahwa; Kim Burchiel; Penelope Hogarth; Eugene C Lai; John E Duda; Kathryn Holloway; Ali Samii; Stacy Horn; Jeff M Bronstein; Gatana Stoner; Philip A Starr; Richard Simpson; Gordon Baltuch; Antonio De Salles; Grant D Huang; Domenic J Reda Journal: N Engl J Med Date: 2010-06-03 Impact factor: 91.245
Authors: D Drapier; J Péron; E Leray; P Sauleau; I Biseul; S Drapier; F Le Jeune; D Travers; A Bourguignon; C Haegelen; B Millet; M Vérin Journal: Neuropsychologia Date: 2008-05-20 Impact factor: 3.139
Authors: Sophie Ory; Florence Le Jeune; Claire Haegelen; Siobhan Vicente; Pierre Philippot; Thibaut Dondaine; Pierre Jannin; Sophie Drapier; Dominique Drapier; Paul Sauleau; Marc Vérin; Julie Péron Journal: J Neuropsychol Date: 2015-12-16 Impact factor: 2.864