Literature DB >> 27730239

Substrate scope for trimethyllysine hydroxylase catalysis.

Abbas H K Al Temimi1, Bas J G E Pieters1, Y Vijayendar Reddy1, Paul B White1, Jasmin Mecinović1.   

Abstract

Trimethyllysine hydroxylase (TMLH) is a non-haem Fe(ii) and 2-oxoglutarate dependent oxygenase that catalyses the C-3 hydroxylation of an unactivated C-H bond in l-trimethyllysine in the first step of carnitine biosynthesis. The examination of trimethyllysine analogues as substrates for human TMLH reveals that the enzyme does hydroxylate substrates other than natural l-trimethyllysine.

Entities:  

Year:  2016        PMID： 27730239     DOI： 10.1039/c6cc07845a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

Review 1.  Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses.

Authors:  Shu-Shan Gao; Nathchar Naowarojna; Ronghai Cheng; Xueting Liu; Pinghua Liu
Journal:  Nat Prod Rep       Date:  2018-08-15       Impact factor: 13.423

2.  Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

Authors:  Roman Belle; Abbas H K Al Temimi; Kiran Kumar; Bas J G E Pieters; Anthony Tumber; James E Dunford; Catrine Johansson; Udo Oppermann; Tom Brown; Christopher J Schofield; Richard J Hopkinson; Robert S Paton; Akane Kawamura; Jasmin Mecinović
Journal:  Chem Commun (Camb)       Date:  2017-12-12       Impact factor: 6.222

3.  1H NMR Metabolic Profiling of Earthworm (Eisenia fetida) Coelomic Fluid, Coelomocytes, and Tissue: Identification of a New Metabolite-Malylglutamate.

Authors:  Corey M Griffith; Preston B Williams; Luzineide W Tinoco; Meredith M Dinges; Yinsheng Wang; Cynthia K Larive
Journal:  J Proteome Res       Date:  2017-08-16       Impact factor: 4.466

Review 4.  Trimethyllysine: From Carnitine Biosynthesis to Epigenetics.

Authors:  Marijn N Maas; Jordi C J Hintzen; Miriam R B Porzberg; Jasmin Mecinović
Journal:  Int J Mol Sci       Date:  2020-12-11       Impact factor: 5.923

5.  L-Carnitine Production Through Biosensor-Guided Construction of the Neurospora crassa Biosynthesis Pathway in Escherichia coli.

Authors:  Pierre Kugler; Marika Trumm; Marcel Frese; Volker F Wendisch
Journal:  Front Bioeng Biotechnol       Date:  2021-04-16

6.  Untargeted 2D NMR Metabolomics of [13C-methyl]Methionine-Labeled Tumor Models Reveals the Non-DNA Methylome and Provides Clues to Methyl Metabolism Shift during Tumor Progression.

Authors:  Daniel Morvan; Florent Cachin
Journal:  J Proteome Res       Date:  2022-02-23       Impact factor: 4.466

7.  Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-Nε-trimethyllysine.

Authors:  Robert K Leśniak; Suzana Markolovic; Kaspars Tars; Christopher J Schofield
Journal:  Chem Commun (Camb)       Date:  2016-12-22       Impact factor: 6.222
  7 in total

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