PURPOSE: Frequent ventricular premature depolarizations (VPDs) may cause cardiomyopathy (VPDCM), which often improves after VPD suppression. This study aimed to evaluate whether ablation of outflow tract ventricular arrhythmias (OT VAs) in patients with VPDCM improves renal in addition to left ventricular (LV) function. METHODS: We retrospectively evaluated 153 patients with OT VAs and examined VPD burden and LV ejection fraction (LVEF), as well as estimated glomerular filtration rate (eGFR) pre- and post-ablation. LV dysfunction was defined as LVEF <50 % and impaired renal function was defined as eGFR of <60 mL/min/1.73m2. RESULTS: Fifty-five patients had VPDCM. During mean follow-up of 14 months, 140 (92 %) were free from arrhythmia. In patients with VPDCM, patients with baseline LVEF 40-50 % had greater improvement in the post-ablation LVEF compared to patients with baseline LVEF <40 % (p < 0.01). At baseline, 36 (72 %) patients had renal dysfunction, 29 (81 %) of whom had improvement in eGFR from baseline after successful ablation from eGFR 51 to 57 mL/min/1.73m2. There was a significant association between cardiac (ΔLVEF ≥10 %) and renal (ΔeGFR ≥10 %) improvement (r = 0.54, p = 0.04). Using logistic regression analysis, procedural success was an independent predictor of improvement of cardiac (odds ratio [OR] = 13.7, p = 0.03) and renal function (OR = 21.0, p = 0.047). CONCLUSIONS: Successful catheter ablation of OT VA reduces VPD burden and is associated with improved cardiac and renal function in patients with VPDCM.
PURPOSE: Frequent ventricular premature depolarizations (VPDs) may cause cardiomyopathy (VPDCM), which often improves after VPD suppression. This study aimed to evaluate whether ablation of outflow tract ventricular arrhythmias (OT VAs) in patients with VPDCM improves renal in addition to left ventricular (LV) function. METHODS: We retrospectively evaluated 153 patients with OT VAs and examined VPD burden and LV ejection fraction (LVEF), as well as estimated glomerular filtration rate (eGFR) pre- and post-ablation. LV dysfunction was defined as LVEF <50 % and impaired renal function was defined as eGFR of <60 mL/min/1.73m2. RESULTS: Fifty-five patients had VPDCM. During mean follow-up of 14 months, 140 (92 %) were free from arrhythmia. In patients with VPDCM, patients with baseline LVEF 40-50 % had greater improvement in the post-ablation LVEF compared to patients with baseline LVEF <40 % (p < 0.01). At baseline, 36 (72 %) patients had renal dysfunction, 29 (81 %) of whom had improvement in eGFR from baseline after successful ablation from eGFR 51 to 57 mL/min/1.73m2. There was a significant association between cardiac (ΔLVEF ≥10 %) and renal (ΔeGFR ≥10 %) improvement (r = 0.54, p = 0.04). Using logistic regression analysis, procedural success was an independent predictor of improvement of cardiac (odds ratio [OR] = 13.7, p = 0.03) and renal function (OR = 21.0, p = 0.047). CONCLUSIONS: Successful catheter ablation of OT VA reduces VPD burden and is associated with improved cardiac and renal function in patients with VPDCM.
Authors: Han S Lim; Scott R Willoughby; Carlee Schultz; Adhiraj Chakrabarty; Muayad Alasady; Dennis H Lau; Kurt C Roberts-Thomson; Matthew I Worthley; Glenn D Young; Prashanthan Sanders Journal: Heart Rhythm Date: 2014-07-25 Impact factor: 6.343
Authors: Jose F Huizar; Karoly Kaszala; Jonathan Potfay; Anthony J Minisi; Edward J Lesnefsky; Antonio Abbate; Eleonora Mezzaroma; Qun Chen; Rakesh C Kukreja; Nicholas N Hoke; Leroy R Thacker; Kenneth A Ellenbogen; Mark A Wood Journal: Circ Arrhythm Electrophysiol Date: 2011-05-16
Authors: Kevin Damman; Vincent M van Deursen; Gerjan Navis; Adriaan A Voors; Dirk J van Veldhuisen; Hans L Hillege Journal: J Am Coll Cardiol Date: 2009-02-17 Impact factor: 24.094
Authors: Lidia Carballeira Pol; Marc W Deyell; David S Frankel; Daniel Benhayon; Fabien Squara; William Chik; Maria Kohari; Rajat Deo; Francis E Marchlinski Journal: Heart Rhythm Date: 2013-11-01 Impact factor: 6.343