Literature DB >> 27723537

A roadmap of the generation of neoantigens as targets of the immune system in type 1 diabetes.

Bart O Roep1, Maria Jl Kracht2, Menno van Lummel3, Arnaud Zaldumbide4.   

Abstract

Type 1 diabetes (T1D) is an autoimmune disease characterized by the selective destruction of the insulin-producing beta cells. Beta cell dysfunction caused by an inflammatory microenvironment is believed to trigger the peripheral activation of CD4 and CD8 autoreactive T cells. This review will compile post-transcriptional and post-translational modifications (PTM) involved in the generation of beta cell neoantigens and proposes a reconstruction of the sequence of events connecting environmental changes and autoimmunity. Copyright Â
© 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Year:  2016        PMID： 27723537     DOI： 10.1016/j.coi.2016.09.007

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  23 in total

1.  T-cell responses to hybrid insulin peptides prior to type 1 diabetes development.

Authors:  Angela M Mitchell; Aimon A Alkanani; Kristen A McDaniel; Laura Pyle; Kathleen Waugh; Andrea K Steck; Maki Nakayama; Liping Yu; Peter A Gottlieb; Marian J Rewers; Aaron W Michels
Journal:  Proc Natl Acad Sci U S A       Date:  2021-02-09       Impact factor: 11.205

2.  The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes.

Authors:  Ernesto S Nakayasu; Wei-Jun Qian; Carmella Evans-Molina; Raghavendra G Mirmira; Decio L Eizirik; Thomas O Metz
Journal:  Expert Rev Proteomics       Date:  2019-06-24       Impact factor: 3.940

Review 3.  Neoepitopes: a new take on beta cell autoimmunity in type 1 diabetes.

Authors:  Stuart I Mannering; Anthony R Di Carluccio; Colleen M Elso
Journal:  Diabetologia       Date:  2018-11-06       Impact factor: 10.122

Review 4.  Extracellular Vesicles in Type 1 Diabetes: Messengers and Regulators.

Authors:  Sarita Negi; Alissa K Rutman; Steven Paraskevas
Journal:  Curr Diab Rep       Date:  2019-07-31       Impact factor: 4.810

Review 5.  Immunological Monitoring in Beta Cell Replacement: Towards a Pathophysiology-Guided Implementation of Biomarkers.

Authors:  Fanny Buron; Sophie Reffet; Lionel Badet; Emmanuel Morelon; Olivier Thaunat
Journal:  Curr Diab Rep       Date:  2021-04-25       Impact factor: 4.810

Review 6.  Combination Immunotherapy for Type 1 Diabetes.

Authors:  Robert N Bone; Carmella Evans-Molina
Journal:  Curr Diab Rep       Date:  2017-07       Impact factor: 4.810

Review 7.  Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the "Scene of the Crime".

Authors:  Sally C Kent; Stuart I Mannering; Aaron W Michels; Jenny Aurielle B Babon
Journal:  Curr Diab Rep       Date:  2017-09-02       Impact factor: 4.810

8.  Optimizing Multiplexed Detections of Diabetes Antibodies via Quantitative Microfluidic Droplet Array.

Authors:  Kai Duan; Gargi Ghosh; Joe Fujiou Lo
Journal:  Small       Date:  2017-10-09       Impact factor: 13.281

Review 9.  HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications.

Authors:  Robert Busch; Simon Kollnberger; Elizabeth D Mellins
Journal:  Nat Rev Rheumatol       Date:  2019-06       Impact factor: 20.543

Review 10.  Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot's Print.

Authors:  Henner Zirpel; Bart O Roep
Journal:  Front Endocrinol (Lausanne)       Date:  2021-04-12       Impact factor: 5.555
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