Literature DB >> 27722534

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition.

Vincenzo Alterio1, Roberta Cadoni2, Davide Esposito1, Daniela Vullo3, Anna Di Fiore1, Simona Maria Monti1, Andrea Caporale1, Menotti Ruvo1, Mario Sechi4, Pascal Dumy5, Claudiu T Supuran6, Giuseppina De Simone1, Jean-Yves Winum5.   

Abstract

In this paper we report the synthesis of a series of benzoxaborole derivatives, their inhibition properties against some carbonic anhydrases (CAs), recognized as important drug targets, and the characterization of the binding mode of these molecules to the CA active site. Our data provide the first experimental evidence that benzoxaboroles can be efficiently used as CA inhibitors.

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Year:  2016        PMID： 27722534     DOI： 10.1039/c6cc06399c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  19 in total

Review 1.  The versatility of boron in biological target engagement.

Authors:  Diego B Diaz; Andrei K Yudin
Journal:  Nat Chem       Date:  2017-07-25       Impact factor: 24.427

2.  Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.

Authors:  Adèle Larcher; Alessio Nocentini; Claudiu T Supuran; Jean-Yves Winum; Arie van der Lee; Jean-Jacques Vasseur; Danielle Laurencin; Michael Smietana
Journal:  ACS Med Chem Lett       Date:  2019-07-11       Impact factor: 4.345

3.  Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study.

Authors:  Alessio Nocentini; Roberta Cadoni; Sonia Del Prete; Clemente Capasso; Pascal Dumy; Paola Gratteri; Claudiu T Supuran; Jean-Yves Winum
Journal:  ACS Med Chem Lett       Date:  2017-10-20       Impact factor: 4.345

4.  Anion inhibition studies of the α-carbonic anhydrases from Neisseria gonorrhoeae.

Authors:  Alessio Nocentini; Chad S Hewitt; Margaret D Mastrolorenzo; Daniel P Flaherty; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

5.  Diaryl Ureas as an Antiprotozoal Chemotype.

Authors:  Derek A Leas; Austin G Sanford; Jianbo Wu; Monica Cal; Marcel Kaiser; Sergio Wittlin; Ryan M Hemsley; Elyssa B Darner; LeeAnna M Lui; Paul H Davis; Jonathan L Vennerstrom
Journal:  ACS Infect Dis       Date:  2021-05-10       Impact factor: 5.578

6.  Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.

Authors:  Ning Zhang; Martin Zoltner; Ka-Fai Leung; Paul Scullion; Sebastian Hutchinson; Ricardo C Del Pino; Isabel M Vincent; Yong-Kang Zhang; Yvonne R Freund; Michael R K Alley; Robert T Jacobs; Kevin D Read; Michael P Barrett; David Horn; Mark C Field
Journal:  PLoS Pathog       Date:  2018-02-09       Impact factor: 6.823

7.  Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles.

Authors:  Alessio Nocentini; Roberta Cadoni; Pascal Dumy; Claudiu T Supuran; Jean-Yves Winum
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

8.  Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors.

Authors:  Morteza Abdoli; Murat Bozdag; Andrea Angeli; Claudiu T Supuran
Journal:  Metabolites       Date:  2018-06-01

9.  High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.

Authors:  Hector Newman; Alen Krajnc; Dom Bellini; Charles J Eyermann; Grant A Boyle; Neil G Paterson; Katherine E McAuley; Robert Lesniak; Mukesh Gangar; Frank von Delft; Jürgen Brem; Kelly Chibale; Christopher J Schofield; Christopher G Dowson
Journal:  J Med Chem       Date:  2021-07-31       Impact factor: 8.039

10.  Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.

Authors:  Pieter C Steketee; Isabel M Vincent; Fiona Achcar; Federica Giordani; Dong-Hyun Kim; Darren J Creek; Yvonne Freund; Robert Jacobs; Kevin Rattigan; David Horn; Mark C Field; Annette MacLeod; Michael P Barrett
Journal:  PLoS Negl Trop Dis       Date:  2018-05-14
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